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  • 1
    Electronic Resource
    Electronic Resource
    Evidence that the Mechanism of Immunological Tolerance (‘Central Failure’) Is Operative in the Lack of Host Resistance in Lepromatous Leprosy (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 1 (1972), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cellular immune defect in lepromatous leprosy has been studied. The following observations have been made: 1) Three lepromatous patients who had been on anti-leprosy treatment for more than 10 years still failed to respond to M. leprae by lymphocyte transformation (mean 0.2%) while they responded strongly to BCG (mean 34.2%) and PPD (mean 56.1%). 2) Lepromatous serum failed to inhibit M. leprae-induced lymphocyte transformation and M. leprae-induced leukocyte migration inhibition. 3) Lepromatous lymphocytes revealed a reduced capacity to attach M. leprae to their surface. The only experimental condition compatible with the observed characteristics would seem to be a state of immunological tolerance to an antigen (or antigens) of M. leprae. The lasting nature of this non-responsive state suggests that it plays a primary role in the pathogenesis of lepromatous leprosy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1972.tb03296.x
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  • 2
    Electronic Resource
    Electronic Resource
    Surface-Bound Immunoglobulin on Lymphocytes from Normal and Immunodeficient Humans (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 1 (1972), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: By means of immunofluorescence technique, lymphocytes with surface-bound immunoglobulin were detected in the blood of normal humans F(ab')2, IgM, IgG, IgA, the four IgG subclasses, and the Gm markers Gm(f) and Gm(Z) were demonstrated on cells. IgM was the dominating class, and IgG2 the dominating IgG subclass. The data suggest that the Ig on any one cell belongs to a single class and IgG subclass. Very few lymphocytes stained for antigens on the C-terminal half of ihe IgG molecule. Ig-positive lymphocytes were also demonstrated in cord blood and in spleen cell suspensions. An almost total lack of Ig-positive lymphocytes was demonstrated in the blood of 8 patients with severe hypogammaglobulinemia. The Ig-positive lymphocytes are thought to be analogous to B-lymphocytes in other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1972.tb03730.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphocyte Populations and Cellular Immune Reactions in Juvenile Rheumatoid Arthritis (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten patients with juvenile rheumatoid arthritis and age- and sex-matched healthy controls were investigated in pairs. The patients were found to have both normal proportions and normal absolute numbers of T lymphocytes, B lymphocytes, and the Fc-receptor-bearing lymphoid cells in peripheral blood. No abnormality of mitogen-induced lymphocyte transformation was observed. Lymphocyte-mediated cytotoxicity induced by phytohemagglutinin (PHA) or anti-target cell antibodies was also found to be normal. As in an earlier study, impaired delayed hyper-sensitivity by skin testing was observed in the patient group, thus indicating a dissociation between in vivo and in vitro parameters of lympboid cell function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02689.x
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  • 4
    Electronic Resource
    Electronic Resource
    Elution and Characterization of Lymphocytes from Rheumatoid Inflammatory Tissue (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocytes were eluted from the synovial tissue of 19 patients with classical rheumatoid arthritis. The tissue was minced and dissociated by treatment with crude collagenase and DNase, The cell suspension obtained was filtered and incubated in plastic culture flasks overnight at 37°C, The cells that did not adhere to the plastic surface were harvested and the lymphocytes further purified by the Ficoll-Isopaque gradient centrifugation technique. The lymphocyte yield varied from 0.64 to 32 × 106 cells. Differential counts showed on the average 85% lymphocytes, 12% macrophage-like cells, and variable proportions of polymorphonuclear granulocytes, unclassified cells, and dead cells. An average of 77% of the cells were viable as assessed by the trypan blue exclusion test. This cell suspension was investigated for lymphocyte populations, T lymphocytes were predominant in all experiments (mean, 73.6%), The mean percentage of B lymphocytes was 9.7%, whereas the proportion of Fc-receptor-bearing lymphocytes was on the average 6.0%,
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02692.x
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  • 5
    Electronic Resource
    Electronic Resource
    Same Idiotypc of B-Lymphocyte Membrane IgD and IgM. Formal Evidence for Monoclonality of Chronic Lymphocytic Leukemia Cells (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 3 (1974), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Idiotypic antisera were raised in rabbits against serum M-cnmponents in two patients with chronic lymphocytic leukemia (CLL) In one of the patients the leukemic cells had membrane-bound IgG. in the other IgM and IgD. The M-components were IgG and IgM. respectively. By immunofluorescence technique the CLL cells were shown to be positive when stained with idiotypic antiserum prepared against the corresponding M component, whereas normal lymphocytes, as well as cells from other CLL patients, were negative. These findings represent strong evidence for the monoclonality of the malignant B cells in CLL The fact that the CLL cells had membrane-bound Ig with the same idiotypic determinants as the corresponding serum M-component indicated that the latter had been synthesized and secreted by the malignant clone of B cells. In further experiments redistribution of membrane-bound Ig on CLL cells bearing both IgM and IgD was induced with idiotypic antiserum This indicated that IgM and IgD on the same cells share idiotypic specificity and therefore have the same variable region and. presumably, the same antibody specificity
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1974.tb01321.x
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  • 6
    Electronic Resource
    Electronic Resource
    Identification, Enumeration, and Isolation of B and T Lymphocytes from Human Peripheral Blood (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 3 (1974), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1974.tb01285.x
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  • 7
    Electronic Resource
    Electronic Resource
    Immunological Features in a Case of Subacute Sclerosing Panencephalitis Treated with Transfer Factor (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 2 (1973), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A report is given on an attempt to treat a 16-year-old boy with rapidly progressing subacute sclerosing panencephalitis (SSPE) with soluble leukocyte transfer factor. Three separate injections, each containing transfer factor from lymphocytes of 450 ml venous blood, were given at three- to four-month intervals. A remission, evidenced by clinical, immunological, and serological criteria, occurred and was sustained in the five months of observation after the last transfer factor injection. The close temporal relationship between start of therapy and onset of remission may suggest effects of transfer factor in this cast of SSPE, although a “spontaneous” remission cannot be wholly excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1973.tb02045.x
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  • 8
    Electronic Resource
    Electronic Resource
    Antibody-dependent Lymphocyte-mediated Cytotoxicity in Man: No Requirement for Lymphocytes with Membrane-bound Immunoglobulin (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 2 (1973), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Normal human lymphocytes, depleted of B-lymphocytes by passage through nylon-wool columns, manifested intact antibody-dependent cell-mediated cytotoxicity. Similar findings were made with lymphocytes from four hypo-gammaglobulinaemic patients lacking B-lymphocytes. It is concluded that antibody-induced cell-mediated cytotoxicity in man is independent of B-lymphocytes, as identifiable by membrane-bound immunoglobulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1973.tb02026.x
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  • 9
    Electronic Resource
    Electronic Resource
    Immunologicai Characterization of Lymphocytes in Lymphoproliferative Diseases. Restriction of Classes, Subclasses, and Gm Allotypes of Membrane-Bound Ig (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 1 (1972), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocytes from nineteen patients with chronic lymphocytic leukemia and two with lymphosarcoma with transformation to leukemia had membrane-bound Ig, showing restriction for Ig class, IgG subclass, Gm allotype, and light chain class. IgM was found on cells from all patients except one, who had IgG. These data, together with results from lymphocyte stimulation in vitro with mitogens, and studies of rosette formation with sheep erythrocytes, suggested that tumor cells were products of monoclonal proliferation of B cells. Lymphocytes in chronic lymphocytic leukemia stained with concanavalin A and with antilymphocyte antiserum as strongly as normal lymphocytes. Lymphocytes from patiems with lymphosarcoma of the bone marrow or aleukemic chronic lymphocytic leukemia usually had a normal percentage of B lymphocytes in blood, but a tendency to restriction to one Ig class on B lymphocytes was seen, Blast cells from patients with acute lymphoblastic leukemia did not have membrane-bound Ig. Lymphocytes from patients with lymphosarcoma of the bone marrow or aleukemic chronic lymphocytic leukemia and from those with acute lymphoblastic leukemia, reacted normally on stimulation in vitro with T lymphocyte mitogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1972.tb03301.x
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  • 10
    Electronic Resource
    Electronic Resource
    Antigen and Unspecific Mitogen Stimulation of Lymphocytes Eluted from Rheumatoid Inflammatory Tissue (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 5 (1976), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocytes were eluted from synovial tissues of 17 patients with classical rheumatoid arthritis, using a procedure previously reported. Stimulation was obtained wit h the unspecific mitogens phytohemaggalutinin (PHA), pokeweed mitogen (PWM), and concanavalin A (Con A) as well as with purified protein derivative of tuberculin (PPD) and mitomycin-C-treated allogeneic lymphocytes, whereas Candida antigen usually gave a low response. The pattern of reactivity o t unspecific mitogens was similar to that obtained with lymphocytes from peripheral blood of rheumatoid arthritis patients. Two different PPD preparations usually gave transformation of the same magnitude as seen with PHA. This was in contrast to the reactivity of the peripheral blood lymphocytes. It could be demonstrated that the elution procedure initiated some degree of lymphocyte transformation, mainly potentiating the responses to PHA and Con A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1976.tb03057.x
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