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  • 1
    Electronic Resource
    Electronic Resource
    Radioimmunoassay of arginine vasopressin, oxytocin and arginine vasotocin-like material in the human pineal gland
    Amsterdam : Elsevier
    Peptides 2 (1981), S. 459-466 
    Details
    ISSN: 0196-9781
    Keywords: Arginine vasopressin ; Arginine vasotocin ; Human pineal ; Oxytocin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0196-9781(81)80105-2
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of almitrine administration on pulmonary arterial pressure in resting and exercising dogs
    Amsterdam : Elsevier
    Respiration Physiology 82 (1990), S. 75-87 
    Details
    ISSN: 0034-5687
    Keywords: Animal ; Exercise ; Pressure ; Pulmonary vascular resistance ; Pulmonary vasoconstriction ; Resistance ; almitrine ; and pulmonary artery pressure ; dog ; pulmonary artery ; pulmonary vascular
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(90)90025-T
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ventilatory transients during exercise: Peripheral or central control? (1983)
    Springer
    Pflügers Archiv 396 (1983), S. 269-276 
    Details
    ISSN: 1432-2013
    Keywords: Control of breathing ; Exercise ; Hypnotic drugs ; Narcotic analgesic drugs ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fast component of the ventilatory changes that occur at the transition phases of exercise was studied in awake dogs trained to run on a treadmill. Two questions were examined: firstly, is the fast ventilatory component modified by changes in venous return to the lungs, such as those consecutive either to increased work loads or to β adrenergic blockade?, and secondly, is this component altered by central ventilatory depressants? The results showed that at the onset of exercise, there is no correlation between the instantaneous increment in ventilation and the intensity of exercise, but at the end of the readmill run, the fall in ventilation is closely linked to the power of the work performed. Ventilatory transients observed either at the start or at the end of exercise remain unaffected by administration of a β-adrenergic blocking agent. But central depressant effects on ventilation caused by narcotic analgesics or hypnotic drugs altered the breathing pattern of the fast component of exercise-induced ventilatory changes. It is concluded that the instantaneous changes in ventilation occurring at the transition phases of exercise are controlled by mechanoreceptor mechanisms, but cerebral control is superimposed on the reflex control in regulating both tidal volume and breathing rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01063930
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Regional blood flow in conscious rats after head-down suspension (1998)
    Springer
    European journal of applied physiology 78 (1998), S. 296-302 
    Details
    ISSN: 1439-6327
    Keywords: Key words Cardiovascular deconditioning ; Head-down suspension ; Microspheres ; Conscious rat ; Regional blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exposure to microgravity in humans causes cardiovascular deconditioning affecting blood pressure, heart rate and vascular responsiveness. This study investigated cardiac output, arterial blood pressure and regional blood flows [radioactive microspheres: 57Co, 15.5 (SEM 0.1) μm in diameter] in conscious and freely moving rats subjected to 14 days of simulated microgravity (head-down suspension, HDS) in male Wistar rats: control (horizontally attached, n = 7), suspended for 14 days (n = 8) and suspended/allowed to recover for 10 min (R10min, n = 5) or 24 h (n = 9). Compared to the control group, 14 days of HDS resulted in reduced total peripheral resistance (37%); an increased cardiac index (65%) was associated with no significant change in the mean arterial pressure . There were elevated brain (63%), visceral (〉20%), hindlimb (〉80%) and forelimb (〉215%) muscle blood flows. In the R10min group, the decreased (18%) and the regional blood flows returned to control values. Within 24 h the as well as cardiac index and total peripheral resistance were restored. In conclusion, 14 days of HDS engendered local circulatory changes resulting in transient blood pressure instability during recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004210050423
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Skeletal muscle adaptation to physical training and beta-adrenergic blockade in spontaneously hypertensive rats (1989)
    Springer
    European journal of applied physiology 58 (1989), S. 652-660 
    Details
    ISSN: 1439-6327
    Keywords: Capillarization ; Swimming ; Spontaneously hypertensive rats ; Fiber type distribution ; Enzymatic activities ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of training alone or in combination with long-term, non-selective, β-adrenergic blockade on histochemical and biochemical properties of fast-twitch [extensor digitorum longus muscle (EDL)] and slow-twitch [soleus muscle (Sol)] muscle were analyzed in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto strain rats (WKY). Fiber type distribution of Sol was drastically modified in SHR with fewer type I fibers and more type IIA fibers. No such histochemical alterations were observed in EDL. While prolonged swimming training remained ineffective in inducing both histochemical and biochemical improvement in WKY, SHR displayed a significant enhancement of capillarization and oxidative capacity in both Sol and EDL. However, in long-term β-blocks rats training failed to improve significantly the oxidative capacity of SHR muscles, suggesting that β-adrenoreceptor stimulation is necessary for a fully efficient adaptation of muscular metabolism to physical training.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418513
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Structural and metabolic properties of rat muscle exposed to weightlessness aboard Cosmos 1887 (1991)
    Springer
    European journal of applied physiology 63 (1991), S. 288-292 
    Details
    ISSN: 1439-6327
    Keywords: Weightlessness ; Histochemistry ; Capillaries ; Enzyme activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male Wistar rats were subjected to 12.5 days of weightlessness aboard Cosmos 1887. Histomorphometric and biochemical analyses were investigated in soleus (SOL), plantaris (PL) and extensor digitorum longus (EDL) muscles of flight rats (group F) and compared with data from two groups of terrestrial controls: one group living free in a vivarium (group V) and another subjected to a flight simulation except for the state of weightlessness (group S). Relative to groups V and S, no alteration in the percentage distribution of fibres had occurred in SOL, PL or EDL, after the flight. In SOL muscles from group F animals, cross-sectional areas of all fibre types were reduced to a greater extent (− 40%) than capillary to fibre ratio (−24%) leading to a higher capillary density (+33%) than in V and S groups. In PL, type I, IIA and IIB fibre cross-sectional areas were less decreased (-25%). In EDL, only fast-twitch fibre cross-sectional areas showed an average decrease of 30%. Capillary per fibre ratio was reduced by 15% and 28% respectively in PT and EDL muscles from group F rats compared to control groups V and S. Citrate synthase and 3-hydroxyacyl-coenzyme A dehydrogenase activities remained unchanged in SOL, PL and EDL following spaceflight. These findings indicate greater atrophy and functional alterations (capillarity) compared to those observed after 7 days of microgravity on Cosmos 1667.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233864
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    Paper (German National Licenses)
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