ISSN:
1435-232X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary We have examined the problem of identifying carriers of hemophilia A by using three comparative studies: the human AHF-inhibitor-neutralization test, the rabbit anti-human AHF antiserum-neutralization test, and quantitative immunoelectrophoresis. Twelve out of 22 (54.5%) definite carriers could be distinguished on the basis of their VIII: C alone; 19 out of 22 (86%) could be detected on the basis of the ratio of VIII: C to VIII: AG at the 99% confidence limit, and 20 out of 22 (91%) could be detected if both were taken into account. It is concluded that consideration of the level of VIII: C as well as the ratio of VIII: C to VIII: AG is the most reliable means of detecting the carrier state. Application of this method to 16 probable and 14 potential carriers identified the carrier state in 11 and 9, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01874070
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