ISSN:
1573-8221
Keywords:
genetic control
;
avidity
;
Ig receptor
;
lymphocyte
;
antigen-binding cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The number and avidity curves of IgM-positive B lymphocytes forming rosettes with trinitrophenyl-treated sheep's erythrocytes (TNP-RFC) were compared in BALB/c, C57BL/6, (C57BL/6×BALB/c)F1, F1×BALB/c, and F1×C57BL/6 mice. Trinitrophenyl-bovine serum albumin (TNP24-BSA), dinitrophenyl-BSA (DNP23-BSA), and sulfanyl-BSA (Sulf17-BSA), in various dilutions, were used as inhibitors. The number of TNP-RFC was 60% greater in the spleen of the BALB/c mice than in that of the C57BL/6 mice. The F1 hybrids occupied an intermediate position, whereas the number of TNP-RFC was 35% greater in F1×BALB/c hybrids than in F1×C57BL/6 hybrids. Inhibition (avidity) curves differed in the two strains and the F1 hybrids tested. It is concluded that the number and avidity of TNP-RFC are under genetic control. Together with the postulated random (stochastic) expression of the V genes (genes of idiotypes?) in lymphocytes this suggests that the simplest mechanism of genetic control may be the ratio between the corresponding groups of V genes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00799219
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