ISSN:
1432-069X
Keywords:
Tetrachlorosalicylanilide
;
Ultraviolet A
;
Photosensitivity
;
Dose responses
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We studied contact photosensitivity (CPS) to tetrachlorosalicylanilide (TCSA) in BALB/cJ mice with various doses of TCSA and UVA at sensitization and challenge. From these studies we recommend the following protocol: sensitization on days 0 and 1 with 50 μl of 1% TCSA followed by 3 J/cm2 of UVA, and challenge on day 7 with 10 μl of 3% TCSA followed by 6 J/cm2 of UVA. This gave an ear swelling response of 27.4±0.6×10-3 (mean±standard error). We also demonstrated that there is reciprocity between volume and concentration of TCSA at sensitization but not between TCSA and UVA doses at sensitization.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00412981
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