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  • 1
    Electronic Resource
    Electronic Resource
    Endometrial hyperplasia and adenocarcinoma during tibolone (Livial®) therapy (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13085.x
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  • 2
    Electronic Resource
    Electronic Resource
    Severe non-diabetic keto-acidosis causing intrauterine death (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb14398.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    PLASMA UNCONJUGATED OESTRIOL IN LATE PREGNANCY : CIRCADIAN VARIATION AND THE EFFECT OF MEALS AND A GLUCOSE LOAD (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Plasma unconjugated oestriol (E3) concentrations were determined by radio-immunoassay in 10 normal subjects in late pregnancy, throughout a normal day and night, and after a 50 g oral glucose load. There was a circadian pattern in E2 concentration characterized by an abrupt increase of 15 per cent at night. There was no significant rhythm during the day or night, taken separately. However there was a 10 to 11 per cent reduction in E3 concentrations soon after some meals and after a glucose load, possibly due to expansion of the plasma volume. Excluding the effect of meals, the fluctuation of E3 concentrations in individuals (median of the coefficients of variation) was 11 5 per cent in the day. Overall, it was 13·2 per cent in the day, 12·1 per cent at night and 15·9 per cent over the whole period studied. Since the variation in plasma unconjugated E3 concentrations through 24 hours was no greater than random fluctuations or day-to-day variation there is no need to restrict the time of blood sampling in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb14941.x
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in fetal monitoring practice in the UK: 1977–1984 (1989)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A postal survey was undertaken between 1985 and 1987 to assess the changes that have taken place in fetal monitoring practice since 1977. Replies were received from 253 (92%) of 276 consultant obstetric units canvassed. Biophysical methods of assessing fetal well-being in the antepartum period are almost universally employed and are accepted as the best discriminators of the need to deliver the pregnancy. The number of fetal heart rate monitors on labour wards has increased by 88%. Overall, 63% of units monitor more than 60% of their patients in labour, and 87% permit suitably trained midwives to apply fetal scalp electrodes, which must now be regarded as standard practice. There is still a need for a simplified technique for fetal blood sampling. The perinatal mortality rate correlates with a prematurity factor and probably bears a greater relation to the population served than to the degree of monitoring provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1989.tb03188.x
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  • 5
    Electronic Resource
    Electronic Resource
    Interruption of first trimester human pregnancy following Epostane therapy. Effect of prostaglandin E2 pessaries (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The effect of Epostane, a competitive inhibitor of the 3β hydroxy steroid dehydrogenase enzyme system in combination with prostaglandin E2 (PGE2) for induction of abortion in early first trimester pregnancy has been studied in a group of 20 women awaiting termination of pregnancy. The women were consecutively assigned to four treatment groups. The first group was treated with PGE2 alone, administered vaginally as a lipid based (Witepsol) pessary. The remaining three groups received Epostane at differing doses for 5 days, and were treated with PGE2 on the fourth day. Significant falls in serum progesterone and oestradiol occurred in the Epostane-treated patients. Abortion was induced in one of the five control patients and in three of 10 patients treated with low doses (300–400 mg) of Epostane. Intra-utrine pressure monitoring showed an increased reactivity to PGE2 in the treated groups. At the highest dose (600 mig) of Epostane, serum progesterone and oestradiol showed the greatest decline to 8% and 21% of the pretreatment values, a prompt and sustained pressure response occurred to PGE2 and abortion was induced in all five patients. A critical degree of progesterone suppression appears to sensitize the myometrium to exogenous prostaglandin. This combined treatment is an effective method of early pregnancy termination and may have a role in the management of mid-trimester abortion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb03078.x
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  • 6
    Electronic Resource
    Electronic Resource
    INTRAPARTUM FETAL MONITORING PRACTICE IN THE UNITED KINGDOM (1979)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In September 1978 a postal survey was made to establish the influence of continuous fetal heart rate monitoring on clinical practice in 264 Consultant Obstetric Units in the United Kingdom. Replies were received from 244 units (92·4 per cent) and only one of these did not possess any fetal heart monitors. The approximate percentage of patients monitored during labour in these units displayed a bimodal distribution with peaks at 20 to 30 and 80 to 90 per cent, reflecting a division of opinion about the need to monitor all or only ‘high risk’ patients. For each hospital the ratio of the numbers of patients delivered during 1977 to the number of monitors was calculated and the values ranged from 172 to 2708. In nearly 25 per cent of the hospitals it was not possible to monitor all high risk patients. Fetal blood pH estimation was used in conjunction with fetal heart rate measurement in 98 hospitals (40·2 per cent) but 38 (15·6 per cent) had a pH meter in or adjacent to the labour ward although this was not used for pH estimation. Midwives were taught to apply fetal scalp electrodes in half of the units but were taught to collect fetal blood samples in only two. It is suggested that there is a need (i) to improve the monitoring facilities in many units, (ii) to encourage midwives to become more involved in practical monitoring techniques and (iii) to develop improved methods for fetal pH determination during labour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb10689.x
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  • 7
    Electronic Resource
    Electronic Resource
    METABOLIC EFFECTS OF BETA-SYMPATHOMIMETIC DRUGS AND DEXAMETHASONE IN NORMAL AND DIABETIC PREGNANCY (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Marked hyperglycaemia and hyperinsulinaemia were observed in two normal women in premature labour treated with an intravenous infusion of a β-sympathomimetic drug and intramuscular dexamethasone injections. Similar therapy in a chemical diabetic patient caused diabetic ketoacidosis, while treatment of an insulin dependent diabetic with dexamethasone alone resulted in a major increase in her insulin requirements. It is suggested that the diabetogenic effects of β-sympathomimetic drugs and dexamethasone may be additive and that regular plasma glucose estimations should be made when they are used, especially in patients with impaired glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb10478.x
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  • 8
    Electronic Resource
    Electronic Resource
    A comparison of the effects of four intravenous solutions for the treatment of ketonuria during labour (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Forty women in whom ketonuria was detected during the first stage of labour were allocated randomly to intravenous treatment with one litre of either normal saline. Hartmann's solution, 5% dextrose or 10% dextrose. The solutions were administered over 1 h and blood was taken immediately beforehand and thereafter at 30-min intervals for 90 min to assess their effect on intermediary metabolism, plasma osmolality and acid-base status. Although both the 5 and 10% dextrose infusions caused a rapid decline in whole blood d-3-hydroxybutyrate concentrations, they also produced pathological degrees of maternal hyperglycaemia and hyperinsulinaemia and a marked elevation in the mean blood lactate and pyruvate concentrations. Administration of 10% dextrose was also associated with a significant increase in serum osmolality. Hartmann's solution produced significantly higher mean whole blood lactate and pyruvate concentrations than did normal saline. There was a significant increase in the venous base deficit in the group infused with 10% dextrose, indicating that the buffering capacity of the blood had been exceeded. It is concluded that rapid infusions of dextrose or Hartmann's solution should not be administered during labour. Normal saline should be used for rehydration and if dextrose therapy is deemed necessary the dose administered should not exceed physiological requirements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01351.x
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  • 9
    Electronic Resource
    Electronic Resource
    Selection of an obstetric data base for a microcomputer and its use for on-line production of birth notification forms, discharge summaries and perinatal audit (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A microcomputer system is described which stores data for perinatal audit and produces‘on-line’the statutory birth notification form and mother and baby discharge summary. The derivation of a minimum data-base and the methods used to obtain reliable data are outlined. The results of a trial of the production of the birth notification form for 195 deliveries are reported together with those of a further trial of 86 deliveries in which the system was used to produce both the notification form and the discharge summary. A study of the accuracy of the handwritten birth notification forms revealed a high error rate which was markedly reduced by the use of the microcomputer system. The system is now in routine use and further developments are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb08613.x
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  • 10
    Electronic Resource
    Electronic Resource
    EVALUATION OF PLASMA GLUCOSE CONTROL IN PREGNANCY COMPLICATED BY CHEMICAL DIABETES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two-hourly plasma glucose measurements were made over a 24-hour period in 24 pregnant women with chemical diabetes treated by dietary carbohydrate restriction alone. The values obtained between midnight and 0600 hours displayed the best correlation with the mean of the diurnal values, the strongest individual correlation being at 0200 hours. During the daytime, the mean of the plasma glucose values before breakfast (0600 hours) and lunch (1200 hours) and two hours after supper (2000 hours) provided the strongest correlation with the mean diurnal value and these are recommended as the routine sampling times for assessment of diabetic control in pregnant women with dietary treatment for chemical diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04564.x
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