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  • 1
    Digitale Medien
    Digitale Medien
    Immunopathologic Role of Proteoglycan Antigens in Rheumatoid Joint Disease (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 11 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cell-mediated immunity to proteoglycan antigens was assessed by leucocyte migration inhibition and by lymphocyte stimulation tests in patients with rheumatoid arthritis or with ankylosing spondylarthritis, in patients with relapsing synovitis after a single trauma to their knee joints, and in healthy donors. Both tests revealed a sensitization in most of the patients examined with various proteoglycan antigens derived from human cartilaginous tissues, rheumatoid synovial fluid, and species-common antigen of bovine nasal cartilage. Anybodies against proteoglycan antigens of human articular cartilage were detected by solid-phase radioimmunoassay in eleven out of twenty-nine sera from patients with rheumatoid arthritis and in four out of six rheumatoid synovial fluids. The results suggest that the cartilage antigenic components released by an inflammatory process or trauma may trigger a vicious circle of chronic inflammation and joint destruction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00232.x
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  • 2
    Digitale Medien
    Digitale Medien
    Cell-mediated and Humoral Immune Responses to Cartilage Antigenic Components (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 9 (1979), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cell-mediated immunity and antibody production to cartilage antigens were studied in rabbits. From day 3 of immunization an inhibition of leucocyte migration was observed in animals immunized with collagen-free fractions of bovine nasal or human rib cartilage. Delayed cutaneous hypersensitivity was elicited between 5 and 6 days and the circulating antibodies were demonstrated by passive haemagglutination on day 9. No significant correlation was observed between the antibody production and the cell-mediated immunity. Cell-mediated immune responses to cartilage antigens and to purified protein derivative were distinctly different, but the two antigens influenced one another when they were administered together. The ‘species common’ antigen of connective tissues may be primarily responsible for the early immune reactions
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1979.tb02704.x
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  • 3
    Digitale Medien
    Digitale Medien
    Serum keratan sulfate-a marker of predisposition to polyarticular osteoarthritis
    Amsterdam : Elsevier
    Clinical Biochemistry 25 (1992), S. 175-180 
    Details
    ISSN: 0009-9120
    Schlagwort(e): ELISA ; aggrecan ; cartilage ; keratan sulfate, osteoarthritis ; proteoglycan ; proteoglycan catabolism ; serum marker
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0009-9120(92)90263-R
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  • 4
    Digitale Medien
    Digitale Medien
    Cartilage proteoglycans as potential autoantigens in humans and in experimental animals (1988)
    Springer
    Inflammation research 23 (1988), S. 63-66 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01967190
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  • 5
    Digitale Medien
    Digitale Medien
    Discoordinate expression of IL-1α and IL-1β in interfacial membranes of failed joint prostheses (1994)
    Springer
    Inflammation research 41 (1994), S. C172 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Bone resorption following either cemented or uncemented total hip replacement has been implicated as an important etiologic factor in aseptic loosening of prostheses, the most frequent cause of clinical failure. Interleukin-1β (IL-1β), collagenase and prostaglandin E2 are considered to play key roles in pathological bone resorption. We have measured the actual levels and quantified the genes coding for several cytokines [IL-1α, IL-1β, IL-4, IL-6, platelet-derived growth factors (PDGF), transforming growth factor-β (TGFβ) and tumor necrosis factor-α (TNFα)] in interfacial membranes obtained from cemented or uncemented loosened joint replacements. IL-1α, IL-6 and TNFα were barely detectable in the interfacial membranes either at protein or mRNA levels, while IL-1β and TGFβ were found to be expressed at the highest levels in freshly isolated tissues. However, the expression of IL-1α increased 10–1000-fold either in isolated cells or explant cultures of interfacial membranes within 24 h. The expression of other cytokines, measured directly in tissue or cells, did not suggest a discoordinate expression of bone-resorbing cellular mediators.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01987626
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  • 6
    Digitale Medien
    Digitale Medien
    Suppression of autoimmune responses and inflammatory events by leflunomide in an animal model for rheumatoid arthritis (1994)
    Springer
    Inflammation research 41 (1994), S. C267 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of leflunomide (HWA 486) was tested in proteoglycan-induced arthritis in an autoimmune animal model showing many similarities to human rheumatoid arthritis and ankylosing spondylitis. The development of the disease in genetically susceptible BALB/c mice is dependent upon the expression of both cell-mediated and humoral immunity to host mouse cartilage proteoglycan. Arthritic and control (non-arthritic) animals were treated with 35 mg leflunomide/kg body weight/day for 12 weeks to suppress inflammatory events and antibody titers. Leflunomide suppressed acute inflammatory events, protected animals from new inflammatory episodes and acute exacerbations, slightly reduced the stiffness in joints and blocked the degradation of cartilage. The suppressive effect of leflunomide in proteoglycan-induced arthritis is due primarily to the suppression of autoantibody formation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01987665
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  • 7
    Digitale Medien
    Digitale Medien
    Localization of antigenic components in proteoglycan aggregate of bovine nasal cartilage (1983)
    Springer
    Histochemistry and cell biology 77 (1983), S. 217-232 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Proteoglycans and glyco(link)proteins are demonstrated in the cartilage matrix using immunohistochemical reactions, ruthenium red staining and concanavalin A-peroxidase procedure. Specific antibodies against proteoglycan monomers revealed a loose matrix structure in the interterritorial area of nasal cartilage. Thin filaments of 49–87 nm in length with a knob on one end corresponding to the protein core of proteoglycan monomers were found in irregular contacts with collagen fibres. Following hyaluronidase digestion the immunohistochemical reactions became more intense, and the matrix structure is suggestive of a network of single filaments which are presumably coupled together longitudinally at the sites of small matrix granules. These matrix granules proved to be glyco(link)proteins of proteoglycan aggregate. Immunohistochemical reactions combined with other methods can reveal an in situ structure of proteoglycan aggregate of hyaline cartilage, which contributes substantially to what has been known about the proteoglycan aggregates on the basis of physico-chemical data and has been verified in monomolecular electron microscopic specimens. The enzymatic treatments of cartilage slices suggest that some of the partially digested proteoglycan monomers are required to be present for the preservation of the structural integrity of cartilage tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00506565
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  • 8
    Digitale Medien
    Digitale Medien
    Appearance and persistence of fibronectin in cartilage (1985)
    Springer
    Histochemistry and cell biology 82 (1985), S. 149-158 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Binding of fibronectins (FN) to collagen types I–IV were studied using polyclonal antibodies against human and chicken FNs, proteoglycan monomers, collagen type II and monoclonal antibodies reacting with both soluble and insoluble forms of human FN. Plasma fibronectin and type II collagen were shown to interact specifically in a homologous system. Type II collagen, however, proved to be less effective in inhibition assays compared to other types of collagen. In high density cultures of chicken limb bud cells, fibronectin was first localized within the fibroblast-like cells of 4 hr cultures and an extensive extracellular filamentous net-work developed by the end of day 1. Fibronectin was present in the newly formed cartilage nodules although it seemed to disappear by day 6, when the proteoglycan accumulation became more intensive. Enzyme treatments (testicular hyaluronidase, chondroitinase ABC) helped to localize FN at this stage of development of chicken cartilage, in microdroplet high density cultures of human fetal chondrocytes and in articular cartilage. Fibronectin was localized only in the pericellular ring of intact human articular cartilage using monoclonal antibodies with the biotin-avidin system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00708199
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  • 9
    Digitale Medien
    Digitale Medien
    The localization of proteoglycans and glycoproteins in the hyaline cartilage (1977)
    Springer
    Histochemistry and cell biology 53 (1977), S. 291-299 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Antibodies to proteoglycan (PG) and glycoprotein of bovine nasal cartilage were conjugated with fluorescein isothiocyanate and with horseradish peroxidase. Hyaluronidase digestion of cartilage tissue-specimens increased the intensity of immune reactions; pronase digestion or extraction with 4 M guanidinium chloride abolished the staining. In the intercellular matrix fine filaments beaded with small granules were seen forming an irregular network. The interstices of the network are filled with collagen fibers linked together by the filaments and granules. In view of the linear conformation of core proteins of PGs and the globular conformation of glycoproteins (link proteins), it may be supposed that the granules and filaments represent these two protein components of PG-aggregates. In chondrocytes a homogeneous staining was recorded in the endoplasmic reticulum, in the juxtanuclear areas and in several smooth-walled vesicles and elongated areas situating subjacent to the cell membrane. In contrast to the extracellular immune reactions, this homogneous intracellular staining was never enhanced by hyaluronidase digestion. This is interpreted in the sense that conformation changes of molecules secreted, and the aggregation of PGs, occur extracellularly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00509246
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