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  • 1
    Electronic Resource
    Electronic Resource
    Effect of dithiothreitol on histamine receptors in rabbit colon and guinea-pig ileum (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 6 (1979), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Dithiothreitol, an agent which reduces disulphide linkages to sulphydryl groups, potentiated the contractile responses of the rabbit colon and guinea-pig ileum to histamine, but had no effect on the resting tone or on the responses of these preparations to acetylcholine.2. The potentiation was greater than that produced by antagonism of histamine's weak inhibitory action by metiamide, and still occurred after blockade of H2-receptors with metiamide; it is concluded that DTT potentiates responses to stimulation of H1-receptors in both preparations.3. In this respect, these H1-receptors resemble those in vascular smooth muscle in the rabbit but not in the guinea-pig; it is concluded that there is a tissue variation rather than a species variation in the response of Hi-receptors in the rabbit and guinea-pig to DTT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1979.tb00019.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    BLOCKADE BY PHENTOLAMINE OF THE POTENTIATION OF HISTAMINE-INDUCED VASOCONSTRICTION CAUSED BY SEROTONIN AND METHYSERGIDE IN THE RABBIT EAR ARTERY (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In subconstrictor doses, both serotonin and methysergide potentiated the vasoconstrictor responses to histamine in the isolated artery of the rabbit ear.2. In the presence of phentolamine (5 μg/ml) the potentiating actions of serotonin and methysergide were significantly reduced.3. This blocking action of phentolamine could be overcome by increasing the concentration of serotonin or by washing the preparation.4. In arteries taken from rabbits pretreated with reserpine, serotonin still potentiated the response to histamine and phentolamine still blocked this potentiation.5. The concentration of phentolamine required to block potentiation also blocked the direct constrictor response to serotonin. It did, however, produce a significantly greater blockade of the vasoconstrictor response to noradrenaline.6. The results indicate that the action of phentolamine in blocking the vascular potentiation produced by serotonin and methysergide is not due to a blockade of α-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02376.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    INCREASED SENSITIVITY OF RABBIT EAR ARTERY TO NORADRENALINE FOLLOWING PERIVASCULAR NERVE STIMULATION MAY BE A RESPONSE TO NEUROPEPTIDE Y RELEASED AS COTRANSMITTER (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Neuropeptide Y (NPY 10-10-10-7 mol/l) had little or no effect on the perfusion pressure of rabbit isolated ear arteries but potentiated the brief contractile responses to injections of noradrenaline, histamine or brief periods of electrical stimulation (2–20 Hz for 5 s). This effect was slowly reversible.2. Similar potentiation was seen following long periods of electrical stimulation (2–40 Hz for 1–5 min) which produced well sustained increases in perfusion pressure.3. Following even longer periods of electrical stimulation (10–30 min) during which the perfusion pressure was not maintained, responses to noradrenaline and histamine were potentiated but the responses to electrical stimulation for 5 s were greatly reduced.4. The increase in sensitivity following prolonged electrical stimulation may be due to NPY released as a cotransmitter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb02636.x
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral Vascular Effects of Mixtures of Isopropylnoradrenaline and Noradrenaline in Man (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 999-999 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] If adrenaline stimulates first the inhibitory and then the excitatory receptors, we might expect its action to be matched by a suitable mixture of iso-propylnoradrenaline and noradrenaline. We have tested this in a series of experiments, of which Fig. 1 shows a typical example. Forearm blood flow ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/196999a0
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    Paper (German National Licenses)
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