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  • 1
    Electronic Resource
    Electronic Resource
    Animal models for percutaneous penetration: assessing contamination of the experimental system (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have used both quantitative and qualitative procedures to assess the validity of percutaneous penetration data obtained from the guinea-pig in vivo. Our results indicate that, under certain, not unusual, experimental conditions the results may be misleading and should be viewed with caution. Contamination of the experimental system, either by simple desquamation from the site of application, or trauma to the site such as rubbing or scratching, may greatly influence the results. We conclude that simple control experiments similar to those described should be conducted when using in vivo animal models for studies on percutaneous penetration, and particularly where the subject is not totally immobilized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb05748.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Trichothiodystrophy: an electron-histochemical study of the hair shaft (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 110 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have used sensitive electron-histochemical methods to study the subtle ultrastructural variations of cystine incorporation into the hair shaft in trichothiodystrophy.We have shown a general reduction in the cystine (sulphur) content of both the cuticle and the cortex Discontinuity, and in some cases, complete absence of the cuticular A-layer results in premature weathering of the cuticle and weakening of the hair shaft. The ultrastructural findings support the work of Gillespie & Marshall (1981) in demonstrating the absence or re-characterization of the high sulphur matrix proteins and show further evidence for the incorporation, and abnormal distribution and deposition of sulphur-rich proteins in hair cortex and cuticle.We conclude that the similar yet different results obtained from each patient's hair sample are characteristic of trichothiodystrophy, a neuro-ectodermal symptom complex which may represent a final common pathway of more than one metabolic disturbance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb04659.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pili annulati: electron histochemical studies on affected hairs (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study we have shown that in pili annulati all the normal layers within each cuticle cell are present, and show a normal distribution of cystine. The presence of well ordered macrofibrils, composed of microfibrils embedded in a cystine rich matrix, in both regions of the hair shaft indicates that normal keratinization can and does take place. We have demonstrated the presence of electronopaque, cystine positive material at the intermacrofibrillar spaces and suggest that the presence of the cortical holes is in part due to insufficient cortical material to occupy the space available, and in part due to the dissolution of the intermacrofibrillar material, possibly by water or other chemical agents, diffusing through an apparently more permeable cuticle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01290.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bubble hair: a cosmetic abnormality caused by brief, focal heating of damp hair fibres (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Following investigation of two individuals with bubble hair abnormality, a reproducible cause has been established. Simple experiments showed that brief, focal heating of damp hair is sufficient to cause bubbles to form inside the hair fibres. This in turn results in weak, dry and brittle hair which breaks easily.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08599.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Generalized trichorrhexis nodosa (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of generalized trichorrhexis nodosa is described in a man. Electron histochemical studies showed abnormal staining consistent with a definite disorder in the formation of alpha-keratin chains within the globular matrix of the hair cortex with respect to cystine; keratin amino-acid analysis also revealed low cystine. This cortical change, together with multiple vacuoles found in the endocuticle, are evidently the intrinsic defeas which allow relatively trivial chemical and physical trauma to cause trichorrhexis nodosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb15842.x
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  • 6
    Electronic Resource
    Electronic Resource
    Trichothiodystrophy: an ultrastructural study of the hair follicle (1985)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 113 (1985), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have used detailed ultrastructural and electron histochemical techniques on both the hair shaft and anagen hair follicle to elucidate further the structural abnormalities in trichothiodystrophic hair. We have shown that protein deposition in the follicle is reduced and lacks orientation, and that the anagen follicles show an overall distortion. Both the hair cuticle and cortex high sulphur protein components are affected. The results of this study help to give a visual interpretation to detailed biochemical studies conducted by other workers thereby allowing specific localization of the site of the intrinsic keratin abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1985.tb02078.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Kwashiorkor: an electron histochemical study of the hair shaft (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 106 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies on hair in kwashiorkor have been equivocal regarding the normal or abnormal incorporation of amino acids into the hair shaft.In this study we have applied a sensitive electron histochemical technique to transverse sections of scalp hair from children with severe kwashiorkor in order to study its infrastructure and the incorporation of sulphur-containing amino acids (cystine). We have found no evidence to support the idea that a protein deficient diet in the weaning or post-weaning period directly affects the distribution and relative amounts of sulphur-containing amino acids in the hair shaft in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb04532.x
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  • 8
    Electronic Resource
    Electronic Resource
    Monilethrix: an electron microscopic and electron histochemical study (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have carried out electron microscopic and electron histochemical investigations on affected hair follicles and hair shafts to elucidate further the structural abnormality in monilethrix. The structural abnormalities manifest in the cortex and cuticle of the hair shaft could be traced to the locality of the ‘zone of keratinization’ of the follicle. Abnormal orientation of the cortical cell proteins, folding of the cuticle cell membrane and varying amounts of endocuticular material were all observed in the region prior to full keratinization. We observed structural abnormalities within all the component layers of the inner root sheath adjacent to the faults within the hair shaft, indicating a possible asynchrony within the monilethrix follicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb00796.x
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    Paper (German National Licenses)
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