Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of periodontal research
20 (1985), S. 0
ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Gingival homogenates (GH) from periodontally diseased subjects were assayed for total immunoglobulins and for antibody to periodontopathic bacteria. Antibody activity in static crevicular fluid (SCF) and GH was compared using an ELISA. Expression of IgG antibody activity per μg IgG or per unit volume of fluid was highly correlated. Antibody activity in 46 SCF and 29 GH from diseased areas in localized juvenile periodontitis and adult periodontitis subjects were compared with serum antibody activity. Twenty of the 46 SCF contained significantly higher concentrations of IgG antibody activity to periodontopathic organisms than found in the respective sera. In addition, 87% of the GH contained higher concentrations of IgG antibody than the corresponding SCF. Variations in IgG antibody concentrations were often seen in different sites from the same subject. GH IgG antibody showed a range of specificities no broader than found in serum from the corresponding subjects when compared against a battery of organisms. Elevated IgA antibody concentrations were also observed in GH. These data support the notion that a significant portion of antibody found in the GH and SCF of periodontally diseased subjects may be locally derived.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1985.tb00447.x
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