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  • 1
    Electronic Resource
    Electronic Resource
    Morphologically distinct patterns of apoptosis correlate with size and high-grade dysplasia in colonic adenomas (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 44 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To examine the relationship of morphological patterns of apoptosis in colonic adenomas to standard pathological variables.Methods and results:  Apoptosis patterns were evaluated in 184 consecutive colonic adenomas and 14 adenocarcinomas, using haematoxylin and eosin sections. Apoptosis identification was selectively validated by electron microscopy. There were three patterns of apoptosis: (i) confluent basal apoptosis; (ii) crypt lumen apoptosis, both assessed semiquantitatively; and (iii) scattered apoptosis (not quantified). Adenoma site, size, type, mitoses, and grade of dysplasia were also assessed. MIB-1 immunostaining was performed in 20 cases. In 142 adenomas (77%) confluent basal apoptosis (n = 124) and/or crypt lumen apoptosis (n = 69) were identified; 42 (23%) had scattered apoptosis only. Significant correlations were: (i) extensive confluent basal apoptosis with small adenomas ≤5 mm (P 〈 0.0001); (ii) crypt lumen apoptosis with large adenomas 〉5 mm (P 〈 0.0001) and (iii) with high-grade dysplasia (P 〈 0.0003); and (iv) coexistence of both patterns (n = 51) with large adenomas 〉5 mm (P 〈 0.0001). Neither apoptosis pattern correlated with other variables. Adenocarcinomas had minimal confluent basal apoptosis (5/14), conspicuous crypt lumen apoptosis (14/14), intraglandular coagulative necrosis, and scattered apoptotic tumour cells.Conclusions:  Confluent basal apoptosis is maximal early in colonic tumorigenesis. The ‘switch’ to a predominant crypt lumen apoptosis pattern suggests that a different apoptosis induction mechanism might be associated with the transition to adenocarcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0309-0167.2004.01813.x
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in regional renal perfusion following ischemia/reperfusion injury to the rat kidney (1991)
    Springer
    Urological research 19 (1991), S. 259-264 
    Details
    ISSN: 1434-0879
    Keywords: Ischemia ; Reperfusion ; Medullary congestion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Post-ischemic renal failure is associated with a zone of vascular hyperaemia in the outer medulla of the kidney. The effect of this lesion on regional renal perfusion is, however, unclear. Acute unilateral renal ischemia was applied to four groups of ten adult male Wistar rats for a period of 60 min, followed by revascularisation for 0, 15, 30 or 60 min. The aorta was then clamped and Microfil was injected at a standard pressure to fill the renal vasculature. Gross and histological examinations of the renal parenchyma and vasculature were then performed. Regional renal Microfil perfusion was quantified by examination of unstained histological sections, giving rise to a vascular perfusion index (VPI) for each vascular region of the kidney. The VPIs were similar in control and ischemic kidneys that were not subjected to reflow (group 1). In contrast, the VPI was markedly decreased in the inner stripe and inner medulla in animals in which revascularisation had occurred (groups 2–4), and the vasculature in these regions was histologically shown to be packed with red blood cells. Post-ischemic renal failure is associated with hyperperfusion of the medulla resulting from blockage of the vasculature that occurs during revascularisation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305308
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment with coumarin to prevent or delay recurrence of malignant melanoma (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. S32 
    Details
    ISSN: 1432-1335
    Keywords: Coumarin ; Melanoma ; Prevention ; Recurrence ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both coumarin (1,2-benzopyrone) and warfarin (4-hydroxycoumarin) have been shown to prevent the recurrence of malignant melanoma. Their action is macrophage-dependent and the dosage is critical. In 1984 a multicentre, prospective, randomised, double-blind trial of coumarin, given as a daily 50-mg dose for 2 years after surgery in patients with high-risk melanoma, was started. The patients had lesions greater than 1.70 mm thick and TNM stage IB or stage II disease. To date there are 4 recurrences in the coumarin-treated group of 13 patients, and 10 recurrences in the placebo-treated group of 14 patients (P〈0.01). There were no toxic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01377122
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  • 4
    Electronic Resource
    Electronic Resource
    A Rapid, Accurate Technique for Determining Densities of High Explosives (1977)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19770020405
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