ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract 1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C- hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C1 CH3 group at 20°C. The products with the ketoesters are converted upon heating to γ-lactams. Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C1 CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20°C to give exclusively γ-lactams and do not give reaction products with hexafluoroacetone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00962396
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