ISSN:
1573-8221
Keywords:
intracellular sodium
;
befol
;
lidocaine
;
cardiomyocytes
;
hypoxia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Using benzofuran isophthalate, a fluorescent probe for sodium ions, intracellular (sarcoplasmic) Na+ concentrations ([Na+]i) were estimated in cardiomyocytes isolated from the left ventricle of rats. Lidocaine (1–100 μM) had little effect on [Na+]i in resting (unstimulated) cardiocytes, while befol lowered it by virtue of its inhibitory effect on Na/H exchange. In cardiomyocytes exposed to “chemical” hypoxia (produced by 5 mM KCN+30 mM 2-deoxyglucoses). [Na+] were three times higher than in resting cells, and the Na-blocking effects of both lidocaine and befol were much stronger. When these two drugs were used together, potentiation of these effects was observed, which may be accounted for by their action on different Na-transporting systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446024
Permalink