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  • 1
    Electronic Resource
    Electronic Resource
    Colorimetric determination of phosphohexose isomerase by thiobarbituric acid reaction
    Amsterdam : Elsevier
    Clinica Chimica Acta 22 (1968), S. 551-561 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(68)90103-4
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  • 2
    Electronic Resource
    Electronic Resource
    Integralabsorption der CO-Valenzschwingungen unverzweigter homologer Aldehyde, Monocarbonsauren und Monocarbonsauremethylester
    Amsterdam : Elsevier
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Section 27 (1971), S. 1279-1284 
    Details
    ISSN: 0584-8539
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0584-8539(71)80080-6
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  • 3
    Electronic Resource
    Electronic Resource
    Structure of the smallest salivary-gland secretory protein gene in Chironomus tentans (1994)
    Springer
    Journal of molecular evolution 38 (1994), S. 482-488 
    Details
    ISSN: 1432-1432
    Keywords: Gene families ; Repeated sequences ; Balbiani ring genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The salivary gland secretion in the dipteran Chironomus tentans is composed of approximately 15 different secretory proteins. The most well known of the corresponding genes are the four closely related Balbiani ring (BR) genes, in which the main part of each approximately 40-kb gene is composed of tandemly arranged repetitive units. Six of the seven additional secretory protein genes described share structural similarities with the BR genes and are members of the same BR multigene family. Here we report the identification of a new secretory protein gene, the spl2 gene, encoding the smallest component of the C. tentans salivary gland secretion. The gene has a corresponding mRNA length of approximately 0.7 kb and codes for a protein with a calculated molecular weight of 7,619 Da. The sp12 gene was characterized in seven Chironomus species. Based on a comparison of the orthologous gene sequences, we conclude that the sp12 gene has a repetitive structure consisting of diverged 21-by-long repeats. The repeat structure and the codon composition are similar to the so-called SR regions of the BR genes and the sp 12 gene may represent a diverged member of the BR multigene family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178848
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  • 4
    Electronic Resource
    Electronic Resource
    Percutaneous treatment with amphotericin B of mycotic lung lesions from invasive aspergillosis: results in 10 immunocompromised patients (2000)
    Springer
    European radiology 10 (2000), S. 1939-1944 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Fungal lung diseases – Aspergillosis – Hematological neoplasms – Immunocompromised host – Interventional procedures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to evaluate the efficacy of percutaneous treatment of pulmonary lesions from invasive aspergillosis in immunocompromised patients. From 1992 to 1998, ten patients (seven men and three women; mean age 56 years) affected by hematological neoplasms (8 acute myeloid leukemias, 2 non-Hodgkin's lymphomas) and post-chemotherapy prolonged neutropenia developed pulmonary lesions from invasive aspergillosis. A total of 13 lesions (diameter 2–7 cm, median 5 cm) were treated percutaneously due to insufficiency of the high-dose i. v. therapy; under CT guidance, a median of 10 cm3 per session of a 1 mg/cm3 diluted solution of amphotericin B was injected through a fine needle (21–22 G); 45 sessions overall were performed (one to five per lesion, median four), according to the volume of the nodules, tolerance, and complications. The results were retrospectively evaluated either radiologically or clinically. Complications were cough, mild hemoptysis, and small pneumothorax and/or pleural effusion. No major complications occurred. One month after the beginning of treatment, 8 lesions completely resolved, 4 greatly improved, and 1 was not significantly reduced. In all ten patients symptoms improved (eight of ten could restart chemotherapy as scheduled). After antiblastic retreatment, 1 patient had mycotic recurrence. In our experience transthoracic topical treatment with amphotericin B of single or few lung lesions from invasive aspergillosis was effective, affording a rapid improvement of the lesions and symptoms, and allowing continuation of chemotherapy as scheduled, thereby reducing the risk of recurrences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300000469
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  • 5
    Electronic Resource
    Electronic Resource
    Systemic arterial air embolism and tension pneumothorax: two complications of transthoracic percutaneous thin-needle biopsy in the same patient (1997)
    Springer
    European radiology 7 (1997), S. 173-175 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Air embolism ; Pneumothorax ; Lung biopsy ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Systemic arterial air embolism and tension pneumothorax are two rare and severe complications of transthoracic fine-needle biopsy. We report on a patient who developed both complications during the same procedure and recovered successfully after resuscitation and hyperbaric oxygen therapy. Favourable outcome of systemic air arterial embolism has been reported infrequently in the literature. In our case tension pneumothorax may have influenced favourably the course of the illness due to collapse of distal airways and the reduction of the venous return to the heart from the affected side.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050129
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  • 6
    Electronic Resource
    Electronic Resource
    Oncological and functional outcome of conservative surgery for primary supraglottic cancer (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 283-290 
    Details
    ISSN: 1434-4726
    Keywords: Key words Supraglottic carcinoma ; Supraglottic ; laryngectomy ; Lymph-node metastases ; Neck treatment ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to verify the oncological and functional outcome of conservative surgical treatment of primary supraglottic squamous cell carcinoma (SGSCC) and related neck disease in order to verify the effectiveness of supraglottic laryngectomy (SL) and the validity of an “observation” policy in the control of clinically negative (N0) necks. Of a total of 252 consecutive patients affected by primary SGSCC seen between 1975 and 1990 at the Department of Otolaryngology of the University of Perugia (1975–1987) and the Catholic University of the Sacred Heart of Rome (1988–1990), a subset of 132 patients treated with classical SL was evaluated after presenting sufficient clinicopathological data and a follow-up period of at least 5 years. Tumors were staged according to the 1992 UICC TNM classification and grouped into stages I-II (n = 94) and III-IV (n = 38). Comprehensive neck dissections were performed only in the clinically positive (N+) necks (25/132 cases), while in the clinically N0 ones (107/132 cases) an “observation” policy under strict follow-up conditions was adopted. After primary surgery, the 5-year relapse-free survival (RFS) was 74%. The RFS was 80% for T1-2 disease and 65% for T3. The RFS was 80% for stages I-II tumors and 71% for stages III-IV. The actual 5-year overall survival (OS) was 89% for T1-T2 tumors and 67% for T3 disease or 93% for stages I-II and 69% for stages III-IV. The OS was 89% for N0 neck and 73% for N+. The 5-year-metastasis-free survival (MFS) was 83% for N0 patients, 74% for N+, 84% for T1-T2 N0, 71% for T1-T2 N+, 81% for T3 N0 and 68% for T3 N+. In all, SL was found to be highly effective in the management of primary SGSCC. In the presence of clinically N0 neck “observation” under strict follow-up with therapeutic comprehensive neck dissection for delayed nodal recurrence, SL was suitable for controlling the neck cancer, as well as for salvaging recurrent disease. Bilateral elective, selective or functional neck dissection in every instance of supraglottic cancer was best performed only in those SGSCC patients who were more likely to have occult nodal disease on the basis of biological factors and imaging data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050247
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  • 7
    Electronic Resource
    Electronic Resource
    Preliminary experiences with contact endoscopy of the larynx (2000)
    Springer
    European archives of oto-rhino-laryngology and head & neck 257 (2000), S. 68-71 
    Details
    ISSN: 1434-4726
    Keywords: Key words Vocal cord pathology ; Contact endoscopy ; Cytological diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nine patients with laryngeal polyps, four with Reinke’s edema, three with leukoplakia, one with papilloma and one with malignant tumor were studied by means of laryngeal contact endoscopy during microlaryngoscopy. This technique allowed in vivo and in situ visualization of the superficial layer of the laryngeal epithelium after staining with methylene blue. Cell structures evaluated were the size and color of the nuclei, the nucleus/cytoplasm ratio, nuclear and cytoplasmic contours, the presence of nucleoli, mitoses and keratoses, as well as the microvascular network of the mucosa and superficial cellular changes from normal to pathological. The normal squamous epithelium of the vocal cord showed a homogeneous cellular population with regular nuclear and cytoplasmic morphological characteristics and a uniform nucleus-to-cytolasm ratio. Specific cellular epithelial patterns and several alterations of the vascular distribution were found in different pathological conditions. Cytological pictures obtained at contact endoscopy were consistent with histological findings in all the patients studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007512
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  • 8
    Electronic Resource
    Electronic Resource
    CO2 laser subtotal arytenoidectomy and posterior true and false cordotomy in the treatment of post-thyroidectomy bilateral laryngeal fixation in adduction (1999)
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 291-295 
    Details
    ISSN: 1434-4726
    Keywords: Key words Airway obstruction ; Vocal cord palsy ; CO2 laser surgery ; Transoral arytenoidectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 39 patients with bilateral post-thyroidectomy vocal cord paralysis in adduction underwent CO2 laser subtotal arytenoidectomies with removal of the posterior third of the false and true vocal cords. Total airway resistance (R tot) evaluated before and 4–10 months after surgery showed marked preoperative impairment before and significant improvement after surgery (P 〈 0.05). In five patients revision surgery was performed due to a progressive impairment of respiratory function. A variable degree of voice breathiness was observed after surgery; the maximum phonation time mean values were lower than normal and peak sound pressure levels 63 ± 5 dB. In three cases aspiration was present in the first postoperative days, but swallowing dysfunctions disappeared within 1 week. Subtotal arytenoidectomy with removal of the posterior third of the true and false vocal folds was found to be a satisfactory surgical treatment for bilateral vocal cord paralysis in adduction. However, further research is still needed to define the surgical procedure able to balance respiratory, phonatory and sphincteric functions optimally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050248
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