ISSN:
1432-1440
Keywords:
Hemophiliacs
;
Human immunodeficiency virus infection
;
Acquired immunodeficiency syndome
;
Intravenous immunoglobulin
;
Therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In children infected with human immunodeficiency virus (HIV) placebo-controlled trials with intravenous immunoglobulins have resulted in a significant reduction in morbidity; however, the results of small trials in adolescents and adults have been inconsistent. In this study 17 HIV-infected hemophiliacs aged 9–30 years were treated with monthly intravenous immunglobulins for an average of 32 months. At the end of the study, 8 years after the HIV infection, three patients (18%) had progressed to the acquired immunodeficiency syndrome(AIDS), and the average decrease in CD4 cells was 81 cells/μl per year. The natural history of HIV infection in hemophiliacs in this age group shows a manifestation rate of AIDS between 11 and 26% 6–8 years after seroconversion and an average yearly decrease in CD4 lymphocytes of 68–110 cells/μl. In conclusion, we observed no difference either in the manifestation rate of AIDS or in prognostic markers in this small cohort of HIV-infected hemophiliacs treated for more than 30% of their latency period with intravenous immunoglobulins compared to the well-documented natural history of HIV-infected hemophiliacs. However, none of the patients developed severe bacterial infections during the study period.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00184588
Permalink
