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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A cytological and virological study was made to determine the incidence of herpes simplex virus (HSV) infection and cytomegalovirus (CMV) infection of the cervix uteri in 197 women attending a venereal diseases clinic. Cervical cytology was compared with virus isolation as a means of detecting these infections. Herpes simplex virus was isolated from 11 out of 186 women appropriately tested (5.9 per cent) and an additional 5 patients (2.7 per cent) showed only cytological evidence of the infection, giving a combined diagnostic rate of 8.6 per cent. Cytomegalovirus was isolated from 12 out of 145 patients suitably tested (8.3 per cent) and an inclusion-bearing cell was identified in one of these patients. An association between CMV and multiple genital warts was noticed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 243 (1973), S. 250-250 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-We would like to correct some of the facts in your News and Views article "Human Papova Viruses" (Nature, 241, 308; 1973). A human papova virus of the polyoma virus subgroup "first came to light" when Zu Rhein and Chou observed by electron microscopy virus particles in brain cells of patients ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Viruses with papovavirus morphology were seen in fluids from baboon kidney cell cultures on three separate occasions (isolates A, B, and C). The size of the virions, 47.9 nm, placed the virus in the polyomavirus genus. It grew well in baboon kidney and Vero cells and less well in human embryo lung (HEL) fibroblasts. The virus could not be identified as the previously described baboon polyomavirus, SA 12, or as any of the other known primate polyomaviruses BK, JC or SV 40, the non-primate viruses mouse polyoma, K, rabbit kidney vacuolating virus (RKV) or bovine polyomavirus (FRKV) by immunofluorescence, immune electron microscopy or hemagglutination inhibition (HI) tests. A rabbit antiserum to the new virus (isolate A) reacted only with the three isolates and not with the other primate polyomaviruses studied. Thirteen percent of 118 wild-caught baboons (Papio anubis) had HI antibody to the new polyomavirus and 21 percent were seropositive for SA 12; only two baboons had antibody to both viruses. These results suggest that in baboons there are two antigenically distinct polyomaviruses which circulate independently. The two viruses may also be distinguished by their hemagglutinating properties: SA 12 agglutinated erythrocytes from a wider range of species but only the newly recognized polyomavirus agglutinated baboon erythrocytes. We propose that the two baboon viruses, SA 12 and the new virus, should be namedPolyomavirus papionis-1 andPolyomavirus papionis-2 respectively.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CMV was isolated from the cervix of 4.2 per cent of 191 gynaecological patients and from 9.8 per cent of 51 women post-partum; all patients were attending the same general practice clinic. The CMV excretion rate was particularly high in the early post-partum period decreasing to nearly normal levels as menstruation returned. Three of 14 (21.4 per cent) post-partum patients excreted CMV before menses had restarted whereas virus was isolated from only two of 36 (5.6 per cent) women who had returned to a normal menstrual cycle. Although this difference was not statistically significant, the excretion rate early post-partum was significantly higher than in the gynaecological group (p〈0.05). Five of seven excretors in the gynaecological group were in the first half of a menstrual cycle at the time of virus isolation thus suggesting that hormonal changes may lead to CMV reactivation in the genital tract. Other factors which may influence the presence of CMV in the genital tract of non-pregnant women are discussed. Three of four infants born to women excreting virus on the cervix post-partum became infected with CMV.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 87 (1986), S. 287-296 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A competitive-type solid phase radioimmunoassay (RIA) was developed for the detection of antibody to bovine polyomavirus. Comparison of RIA and counter-immunoelectrophoresis (CIE) results on 273 cattle sera indicated that both techniques were detecting antibody of like specificity. Human sera from 256 blood donors, 219 people recently vaccinated against polio, rubella or rabies, 50 immunosuppressed patients and 472 people with various occupational exposure to cattle were tested for antibody to bovine polyomavirus, the foetal rhesus monkey kidney strain, (anti-FRKV) by RIA. Apart from one blood donor and one of 108 rabies vaccinees only those in close contact with cattle possessed anti-FRKV. Compared with 62 per cent seropositive in the natural hosts, cattle, 71 per cent of veterinary surgeons, 50 per cent of cattle farmers, 40 per cent of abattoir workers, 16 per cent of veterinary institute technical staff and 10 per cent of veterinary students were anti-FRKV positive. Our findings indicate that the theoretical hazard of FRKV infection from undetected contamination of current tissue culture derived vaccines may, in practice, be remote. Proposed wider use of primate kidney cells as substrates for new vaccines may increase this risk.
    Type of Medium: Electronic Resource
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