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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Chapman and Hall
    International journal of cosmetic science 19 (1997), S. 0 
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence of a liposomal formulation of a ceramide/phospholipid mixture on the barrier function of the skin in atopic tests, in subjects with healthy skin, and after lipid extraction was tested. The transepidermal water loss and the stratum corneum hydration served as parameters for the evaluation of the influence of the ceramide/phospholipid-mixture treatment on the barrier function. Additionally a barrier-function test with nicotinic acid ester was performed after ceramide/phospholipid-mixture application. Stabilizing effects on the barrier function after application of ceramide/phospholipid-mixture were found only in atopic skin and after lipid extraction but not in healthy skin. The results lead us to expect positive effects of ceramide/phospholipid-mixture only if barrier damage is present. On a teste l'influence d'une formulation aux liposomes d'un melange ceramide/phospholipide sur la fonction protectrice de la peau de personnes lors d'un test atopique, sur une peau saine, et apres extraction lipidique. On a utilise la perte d'eau transepidermique et l'hydratation de la couche cornee comme parametres d'evaluation de l'influence du traitement sur la fonction protectrice. On a en outre effectue apres application un test de la fonction protectrice avec un ester d'acide nicotinique. On a constate des effets stabilisateurs de la fonction protectrice apres application seulement sur peau atopique et apres extraction lipidique mais pas sur peau saine. Les resultats nous conduisent a esperer des effets positifs uniquement en cas d'alteration de la fonction protectrice de la peau.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 20 (1986), S. 147-173 
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 10 (1976), S. 209-252 
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 32 (1995), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Damage to the skin following the repeated use of 2 different wash solutions was investigated. Stratum corneum capacitative resistance, stratum corneum lipids, transepidermal water loss, skin surface pH, laser Doppler flow and skin reddening were determined. All skin function parameters already showed a marked change after a single wash (e.g., the median of TEWL values increased by more than 0.5 g/m2 h). Repetitive washing for 1 week led to a further deterioration of TEWL and corneometry values (e.g., TEWL increased for about 2.9 g/m2 h after repetitive washing with sodium lauryl sulfate). The rate of skin function regeneration after repetitive washing was unaltered compared to regeneration after a single wash. The surfactants used showed quantitatively differing effects on corneometry, TEWL and laser Doppler flow (e.g., after repetitive washing with Geli-derm, the median of TEWL values increased only up to 1.55 g/m2 h). However, damage arising from repetitive washing could not be completely prevented by the selection of a mild surfactant. Skin function regeneration showed no difference with the 2 surfactants used.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 6 (1990), S. 679-714 
    ISSN: 0743-4634
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 63 (1994), S. 487-526 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 22 (1990), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 20 (1989), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 39 (1998), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It was the aim of our studies to estimate predictively the individual eczema risk for persons due to repetitive contact with washing-active substances, by a barrier function test on clinically healthy skin over 2 weeks. Within the scope of the study 3 groups with different atopy scores were compared. As washing solutions, 0.1m SLS and a slightly acid soap-free washing emulsion were used in comparison to tap water. Prior to the 1st washing procedure, on days 3, 5, 8, 10, and 12, the transepidermal water loss, the horny layer moisture, and the skin blood flow were measured as parameters of barrier function, as well as the inflammatory reaction. The results prove that the atopy score has only limited validity as a predictive method for the acceptance of washing-active substances. The repetitive washing test, however, seems to be more adequate for evaluating the individual barrier function as well as the eczema risk. Irritation by a washing procedure may be greatly influenced by choice of the washing solution.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Skin research and technology 5 (1999), S. 0 
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In dermatology and cosmetics, moisturizers are used to soften skin. The objectives of this study were to compare the influence of three different moisturizers on skin hydration and skin mechanics by various non-invasive test methods and to determine the relationship between the methods used.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:In 27 test subjects, four test areas in each were treated over 3 days, three times a day. An oil-in-water (o/w) emulsion was applied without moisturizer, the same with 10% glycerol, with 10% urea, or with 10% propylene glycol, respectively. Three hours after the last treatment results were measured by using the following instruments: Corneometer CM 820, Skicon 200, Frictionmeter, and Cutometer.〈section xml:id="abs1-3"〉〈title type="main"〉Results/Conclusions:In all procedures a significant effect, in the sense of an increase in the data recorded, could be demonstrated by glycerol-treatment. During Corneometer, Frictionmeter, and Cutometer measurements, an additional unidirectional effect caused by the basic emulsion was seen. With all test methods, the influence of urea and propylene glycol was not significant compared to the basic emulsion. For all pretreatments there was a correlation between Corneometer data and Skicon data. Because of the low correlation coefficients between hydration parameters and mechanical parameters, it is to be assumed that other effects of glycerol- and basic-emulsion-treatment-independent from the hydration effect – have an additional influence on the data obtained by using the Frictionmeter and the Cutometer. This indicates that the clinical effect of emulsions should not be evaluated exclusively on the basis of electrical measurements of hydration.
    Type of Medium: Electronic Resource
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