ISSN:
1432-2277
Keywords:
Key words Heat shock protein
;
Human kidney transplantation
;
Rejection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Because of the prevailing evidence that heat shock proteins (hsp) are involved in transplantation immunology, we investigate in this study the serum levels of anti-hsp60, and anti-hsp70 antibodies in human kidney allograft recipients. We analyzed 67 sera from 20 patients immediately before and 2 weeks after receiving a kidney allograft, and from 27 healthy age-matched controls with an ELISA. Eleven kidneys had normal allograft function, six had a mild rejection episode, all of which could be reversed successfully; three kidneys had to be removed later on because of resistant rejection. Hsp antibody frequency and titres were the same for transplant recipients and for healthy controls. In patients receiving a kidney allograft, no difference in the level of hsp-antibodies before and after transplantation was observed. Additionally, anti-hsp60 and anti-hsp70 antibody titres were found to be independent of the clinical course. These data suggest that the determination of anti-hsp60 and 70 antibody titers are of no diagnostic value for renal allograft rejection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001470050007
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