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  • 1
    Electronic Resource
    Electronic Resource
    Human Apolipoprotein E Isoform-Specific Differences in Neuronal Sprouting in Organotypic Hippocampal Culture (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract : The apolipoprotein E (ApoE) ε4 allele is a major risk factor for neurodegenerative conditions, including Alzheimer's disease. A role for ApoE is implicated in regeneration of synaptic circuitry after neural injury. In the in vitro mouse organotypic hippocampal slice culture system, we previously showed that cultures derived from ApoE-knockout mice are defective in mossy fiber sprouting into the dentate gyrus molecular layer. This sprouting defect was rescued in cultures from transgenic mice expressing ApoE3 under the control of the human promoter and in ApoE-knockout cultures treated with ApoE3-conditioned media. Although the ApoE3 transgene fully restored sprouting, ApoE4 restored sprouting to only 58% of ApoE3 levels. These data indicate that ApoE isoform-specific effects on neuroregeneration may contribute to its genetic risk for Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0732613.x
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  • 2
    Electronic Resource
    Electronic Resource
    Photolysis of Methyl Acetate (1964)
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 1211-1212 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The mechanism involving reactions (1) and (2) was postulated on evidence obtained from the addition of hydrogen iodide, deuterium iodide and hydrogen bromide to the system. However, the results also show the presence of small amounts of methoxy radicals and dimethyl peroxide. The dimethyl peroxide ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2011211b0
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  • 3
    Electronic Resource
    Electronic Resource
    Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene (1998)
    Springer
    Neurogenetics 1 (1998), S. 267-272 
    Details
    ISSN: 1364-6753
    Keywords: Key words TSC2 ; Mutation/polymorphism ; Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Tuberous sclerosis complex (TSC) is an autosomal dominant multi-system disorder with two known disease loci on chromosomes 9q34 ( TSC1 ) and 16p13.3 ( TSC2 ). TSC has a prevalence of approximately 1 in 5,000–6,000, exhibits incomplete penetrance, and occurs in all racial groups. Our laboratory has undertaken the complete mutation analysis of the TSC2 gene in 42 TSC families using single-strand conformation polymorphism analysis and reverse transcription-polymerase chain reaction. Of the total of 42 families, 16 show evidence of linkage to the chromosome 16 TSC2 locus and 26 are either sporadic or too small to establish chromosome linkage. The TSC2 gene spans at least 45 kilobases of genomic DNA, has 41 known exons, and codes for a 5,474-base pair transcript. After complete gene analysis, 16 TSC2 mutations have been identified, including DNA insertions, deletions, splice site mutations, and amino acid substitutions. The majority of putative TSC2 mutations were found in sporadic rather than TSC2 -linked families. We have also detected 15 polymorphisms which occur in the TSC2 gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100480050039
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  • 4
    Electronic Resource
    Electronic Resource
    Separators in Graphs with Negative and Multiple Vertex Weights (1999)
    Springer
    Algorithmica 23 (1999), S. 57-71 
    Details
    ISSN: 1432-0541
    Keywords: Key words. Graph separator, Cutset, Divide-and-conquer algorithm, Separator theorem, Graph algorithms.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. A separator theorem for a class of graphs asserts that every graph in the class can be divided approximately in half by removing a set of vertices of specified size. Nontrivial separator theorems hold for several classes of graphs, including graphs of bounded genus and chordal graphs. We show that any separator theorem implies various weighted separator theorems. In particular, we show that if the vertices of the graph have real-valued weights, which may be positive or negative, then the graph can be divided exactly in half according to weight. If k unrelated sets of weights are given, the graph can be divided simultaneously by all k sets of weights. These results considerably strengthen earlier results of Gilbert, Lipton, and Tarjan: (1) for k=1 with the weights restricted to being nonnegative, and (2) for k〉1 , nonnegative weights, and simultaneous division within a factor of (1+ε ) of exactly in half.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00009250
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetic Mass Spectrometric Study of the Flash Photolysis of NO 2 (1971)
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 41-41 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The technique was checked by flash photolysing a 3 : 1 mixture of hydrogen and nitrogen dioxide. When profiles of peaks at m/e 17 and 18 were compared, it was found that there was an initial excess intensity of the m/e 1 7 peak which corresponded to that attributed by Meyer, in a similar ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/229041a0
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic studies in autistic disorder and chromosome 15 (2000)
    Springer
    Neurogenetics 2 (2000), S. 219-226 
    Details
    ISSN: 1364-6753
    Keywords: Key words Autistic disorder ; Chromosome 15q11-q13 ; Linkage ; Increased recombination ; Gamma-aminobutyric acidA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT¶Autistic disorder (AD) is a developmental disorder affecting social interactions, communication, and behavior. AD is a disease of complex genetic architecture. It is postulated that several genes contribute to the underlying etiology of AD. Chromosome 15 is of particular interest due to numerous reports of AD in the presence of chromosomal abnormalities, located mainly in the 15q11-q13 region. There are also a number of plausible candidate genes in this area, including the gamma-aminobutyric acidA (GABAA) receptor gene complex. We have undertaken a study of this region of chromosome 15 in a data set of 63 multiplex families (with 2 or more AD affected individuals per family). We found evidence in support of linkage to the 15q11-q13 region, as well as evidence of increased recombination in this region. These findings provide further support for the involvement of chromosome 15q11-q13 in the genetic etiology of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100489900081
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  • 7
    Electronic Resource
    Electronic Resource
    Lewy body and Alzheimer pathology in a family with the amyloid-β precursor protein APP717 gene mutation (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 145-152 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer’s disease ; Dementia with Lewy bodies ; Parkinson’s disease ; APP717 gene mutation ; Beta amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutations in the amyloid precursor protein (APP) gene cause one form of early onset familial Alzheimer’s disease (AD). One such family has been studied genetically and neuropathologically and represents the basis of the present report. Four siblings with the APP717 Val to Ile mutation, aged 59, 65, 61 and 64 years, apolipoprotein E (APOE) genotyped 2,4 (first three) and 2,3 respectively, had severe AD, Braak stage VI with frequent neurofibrillary tangles in the primary visual cortex, Brodmann area 17. The first one also met McKeith criteria for the limbic stage of dementia with Lewy bodies but did not have substantia nigra Lewy bodies. The second two met McKeith criteria for the neocortical stage of dementia with Lewy bodies and both had substantia nigra Lewy bodies. The fourth had AD but no Lewy bodies. A cousin without the APP717 mutation who was APOE 3, 4, developed dementia at age 60 and died at age 75. She had severe cerebrovascular atherosclerosis, less severe AD, Braak stage V, with sparing of area 17. She also had Lewy bodies in the substantia nigra and in the cortex and met McKeith criteria for neocortical stage of dementia with Lewy bodies. Extrapyramidal features were present in all five. Lewy bodies have been described in 53% of reported autopsies on individuals with the APP717 Val to Ile mutation coincident with dementia and AD neuropathologic changes. These observations suggest an association between the chromosome 21 APP mutation and Lewy body formation, possibly mediated by other environmental or genetic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004019900155
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  • 8
    Electronic Resource
    Electronic Resource
    Uniaxial compaction behavior of filled polymer powders (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 33 (1987), S. 2305-2316 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A simple method is described to obtain rheological data on filled polymeric materials in the form of powders. The powder is compacted in a cylindrical chamber by a plunger driven by the cross-head in an Instron testing machine and the load-displacement curve is recorded. Further information is obtained by compressing the powder to a fixed load and measuring the load decay with time (stress-relaxation). The tests are illustrated by application to “monocomponent toner” powders used in dry copying or nonimpact printing processes. It is shown that compaction and stress-relaxation data are able to differentiate between different toners and facilitate the prediction of their relative performances in terms of pressure fusing. A mechanical spring-dashpot-slider model is effective in describing the rheological behavior of these powders and its dependence on the loading of a hard filler (magnetic pigment). The latter affects the “slider” yield stress in the model but has no influence on the relaxation times.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070330704
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  • 9
    Electronic Resource
    Electronic Resource
    Increase in crystallinity in poly(vinylidene fluoride) by electron beam radiation (1987)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 25 (1987), S. 717-722 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: We examine the influence of high-energy radiation and subsequent aging and orientation on the degree of crystallinity of poly(vinylidene fluoride) (PVDF) films. In particular, PVDF films were exposed to electron beam radiation (doses up to 50 Mrad) and aged at room temperature for varying lengths of time followed by uniaxial orientation. The degree of crystallinity of these films was found to increase significantly with increasing radiation dose. In addition, a further substantial increase in the degree of crystallinity was observed upon subsequent aging of irradiated films at room temperature. Upon orientation, in addition to a further rise in the degree of crystallinity, the crystallites were observed to undergo the α form → β form transformation, the latter phase being the polar phase effective for piezo-electric/pyroelectric activity.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1987.090250402
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  • 10
    Electronic Resource
    Electronic Resource
    The mass spectrometric fragmentation of n-benzylacetamide (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 320-320 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The low energy mass spectra of N-benzylacetamide have been recorded. The major fragmentations of the molecular ion are similar to those observed in the acetanilide spectrum. In addition, the secondary dissociation of the [C6H5CH2NH]+ ion by loss of HCN is shown to occur with transfer of the -N-H hydrogen to the ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210100411
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