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  • 1
    Electronic Resource
    Electronic Resource
    Raynaud's phenomenon and digital necrosis induced by interferon-alpha (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report two patients treated with interferon-alpha who developed Raynaud's phenomenon followed by multiple digital necrosis. Arteriography of the legs revealed diffuse distal narrowing. Histological examination of the resected tissue showed ischaemic necrosis within the dermis and subcutaneous tissue without vasculitis. Resolution of the symptoms was observed when interferonalpha was withdrawn. Since other causes of Raynaud's phenomenon and digital necrosis were ruled out, a drug cause is likely. Raynaud's phenomenon should be looked for in patients treated with interferon-alpha. If present, immediate withdrawal of the drug is required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-1028.x
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  • 2
    Electronic Resource
    Electronic Resource
    Histochemical and ultrastructural study of diffuse melanoderma after bone marrow transplantation (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Hyperpigmentation is a well-recognized feature of cutaneous graft-versus-host disease (GVHU). and is usually restricted to sites where lichenoid or sclerodermiform lesions have occurred. Since 1975, two of 745 patients treated by allogeneic bone marrow transplantation in our institution have developed diffuse melanoderma which differed considerably from the classic presentations. They both developed acute GVHD. then lichen planus-like chronic lesions and diffuse melanoderma. Histology of biopsies of the pigmented skin showed intense pigment deposition in the basal and suprabasal layers, and in dermal macrophages. On split-dopa, melanocyte counts were 98 and 93 per Held, respectively. Electron microscopy showed melanocytes protruding into the dermis, and dark melanosomes in all epidermal layers and in macrophages. These findings were suggestive of post-inflammatory hyperpigmentation. In bone marrow recipients, de nova melanoderma is a rare event which could represent a feature of cutaneous GVHD in pigmented subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07622.x
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  • 3
    Electronic Resource
    Electronic Resource
    Bone marrow graft of a Fanconi's anemia patient. Cytogenetic study
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 2 (1980), S. 127-130 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(80)90055-2
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  • 4
    Electronic Resource
    Electronic Resource
    Fanconi's anaemia associated with multicentric Bowen's disease and decreased NK cytotoxicity (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a patient with Fanconi's anaemia and multiple lesions of vulvo-anal Bowen's disease. She was thrombocytopenic and lymphopenic. and NK-mediated cytotoxicity was undetectable. The vulvar lesions did not contain papillomavirus DNA. In vitro studies showed a possible benefit from acitretin treatment on bone marrow stem cells. However, low-dose acitretin given for 14 months did not prevent the development of an anal squamous carcinoma. Acitretin therapy was, however, associated with a sustained rise in the platelet count.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb00497.x
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  • 5
    Electronic Resource
    Electronic Resource
    Localized scleroderma-like lesions on the legs in bone marrow transplant recipients: association with polyneuropathy in the same distribution (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report two patients who developed localized scleroderma-like lesions on the legs following bone marrow transplantation. These changes were associated with a polyneuropathy in the same distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03530.x
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  • 6
    Electronic Resource
    Electronic Resource
    Immunofluorescent tracing of cytoplasmic components involved in keratinocyte differentiation (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 98 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sera with epidermal cytoplasmic antibodies (E.C.A.) produced by human subjects after bone marrow transplantation have been studied by indirect immunofluorescence on rabbit lip sections. These sections were used in order to give on a single specimen, areas of mucosa, of parakeratotic and of orthokeratotic epithelium. It has been demonstrated that E.C.A. distinguished the basal cell layer from the upper cell layers on the three areas. Moreover, E.C.A. were not found to react identically on mucosal, parakeratotic and orthokeratotic epithelium. These findings strongly suggest that the target antigens for E.C.A. are molecules involved in keratinocyte differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb01617.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cytoplasmic and HL-A antigens in the human epidermis (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 96 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: HL-A antisera were found to react, in indirect immunofluorescence on human skin, with the cytoplasm of the upper cell layers of the epidermis. It has been established that this staining was not due to an HL-A-antigen-antibody reaction but rather to a contamination of HL-A antisera with non-HL-A epidermal cytoplasmic antibodies. These findings ruled out a previous hypothesis that HL-A antigens were expressed in the cytoplasm of the upper epidermal cell layers. The localization of HL-A antigens in the human epidermis has not been demonstrated by use of indirect immunofluorescence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb05203.x
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  • 8
    Electronic Resource
    Electronic Resource
    Patents versus transplants (1996)
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 108-108 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - In 1989, Gluckman and colleagues reported that haematopoietic stem cells from umbilical-cord blood of a neonate could be used as an alternative to bone marrow to engraft the donor's HLA-identical sibling who had Fanconi's anaemia. Seven years later, this patient is alive and apparently cured. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/382108a0
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  • 9
    Electronic Resource
    Electronic Resource
    Prevention and treatment of CMV infection after allogeneic bone marrow transplant (1992)
    Springer
    Annals of hematology 64 (1992), S. A158 
    Details
    ISSN: 1432-0584
    Keywords: CMV infection ; Treatment ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CMV infection is the major infectious complication following bone marrow transplantation. It is most often related to reactivation of latent infection in patients who were CMV seropositive before BMT. The incidence and severity have recently been modified by the use of preventive and curative treatments. Prevention of CMV infection with the transfusion of seronegative blood products is useful only when donor and recipient are seronegative. High-dose acyclovir has been shown effective in one randomized study. A multicenter study is currently being performed in Europe to confirm this result. Intravenous gammaglobulins seemed to lower the number of patients who incur interstitial pneumonitis but not the incidence of viremia. They also decreased the incidence of gram-negative sepsis and severe GVH and improved survival. The treatment is based on the use of gancyclovir. Several studies show that gancyclovir is more effective in asymptomatic patients with viral isolation from blood or bronchoalveolar lavage. The addition to gancyclovir of high-dose gammaglobulin improves survival in symptomatic patients with interstitial pneumonitis. This progress in the prevention and treatment of CMV infection has improved the overall results of allogeneic bone marrow transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715372
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  • 10
    Electronic Resource
    Electronic Resource
    Umbilical cord blood transplant in human (1997)
    Springer
    Hematology and cell therapy 38 (1997), S. 393-397 
    Details
    ISSN: 1279-8509
    Keywords: Human umbilical cord blood ; Hematopoiesis ; Hematopoietic stem cell transplant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human cord and placental blood provides a rich source of hematopoietic stem cells. On the basis of the finding, umbilical cord blood stem cells have been used to reconstitute hematopoiesis in children with malignant and non malignant diseases after treatment with myeloablative doses of chemoradiotherapy. Early results show, that a single cord blood provides enough hematopoietic stem cells to provide short and long term engraftment and, that the incidence and severity of graft versus host disease has been low even in HLA mismatched transplants. These results are encouraging enough to embark on large scale banking of cord blood for purposes of future allogeneic and autologous stem cell transplantation, to promote studies on the unique properties of fetal and neonatal hematopoiesis, to study the immunological properties of cord blood cells and, to initiate investigations on gene transfer into human cord blood cells for future gene therapy trials. This review will briefly summarize the current knowledge on cord blood transplantation as well as the future development of research on this unique source of hematopoietic stem cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00282-996-0393-1
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