ISSN:
1573-8221
Keywords:
norbornan
;
GABA A receptors
;
chloride ionophore
;
GABAlytics
;
acylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In vitro experiments demonstrate the high affinity of the toxic convulsant norbornan [2,2-di-(trifluoromethyl)-3,3-dicyano-5,6-dichloronorbornane] for the GABAA-receptor chloride channels of membranes from rat brain. Repeated washing and centrifugation do not restore the ionophore density on norbornan-treated membranes, suggesting that norbornan may be counted among the agents acylating the chloride channels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446741
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