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  • 1
    Electronic Resource
    Electronic Resource
    Validating Benefit and Cost Estimates: The Case of Airbag Regulation (2002)
    350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . : Blackwell Publishing, Inc.
    Risk analysis 22 (2002), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Preregulation estimates of benefits and costs are rarely validated after regulations are implemented. This article performs such a validation for the mandatory automobile airbag requirement. We found that the original 1984 model used to estimate benefits became invalid when 1997 values were input into that 1984 model. However, using a published 1997 cost-effectiveness model, we demonstrate, by replacing the model inputs with the values from 1984, that the 1997 cost-effectiveness ratios, based on real-world crash data and tear-down cost data, are less attractive than what would have been originally anticipated. The three most important errors in the 1984 input values are identified: the overestimation of airbag effectiveness, the overestimation of baseline fatality/injury rates, and the underestimation of manual safety belt use. This case study, which suggests that airbags are a reasonable investment in safety, shows that the regulatory analysis tools do not always produce findings that are biased against health, safety, and environmental regulation. Future validation studies of health, safety, and environmental regulation should focus on validation of benefit and risk estimates, areas where we found significant error, as well as on cost estimates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0272-4332.00070
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  • 2
    Electronic Resource
    Electronic Resource
    Child Passenger Safety: Decisions about Seating Location, Airbag Exposure, and Restraint Use (2000)
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Risk analysis 20 (2000), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The installation of passenger-side airbags in new vehicles complicates efforts to maximize child safety in motor vehicle crashes. It has been recommended by both public and private organizations that children sit in the rear seat with proper restraint to achieve maximum safety. Drivers now need to decide whether a child should be restrained, where the child should be seated (front versus rear), and whether the child should be seated in front of a passenger-side airbag. This research was undertaken to determine which choice minimizes the risk of fatality to children. Using data from the U.S. Fatality Analysis Reporting System for calendar years 1989 to 1998, fatal vehicle crashes with child passengers younger than 13 years were analyzed. The effectiveness of passenger-side airbags and rear seating for children, by age category and restraint use, was estimated using the double-pair comparison method. For each of four age categories, the fatality risk of each possible combination of restraint use, seating location, and airbag presence was also estimated using logistic regression. Passenger airbags were associated with an increase in child fatality risk of 31% for restrained children, and 84% for unrestrained children. Passenger airbags did appear to offer protection to restrained 9- to 12-year-old children. Restraint use and rear seating were associated with statistically significant reductions in the odds of a child dying in a crash. In order to minimize child fatality risk, parents should seat children in the rear of the vehicle while using the proper child restraint system, especially in vehicles with passenger airbags. These findings support current public education efforts in the United States.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0272-4332.204049
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal degradation of chlorophenoxy acid herbicides (1988)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 36 (1988), S. 649-653 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00081a061
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical Characterisation of Geological Raw Materials Used in Traditional Ceramics (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Geostandards and geoanalytical research 28 (2004), S. 0 
    Details
    ISSN: 1751-908X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A wide range of natural raw materials is used in the manufacture of traditional ceramic products such as ceramic tiles, frits, glazes and pigments. The chemical composition of these raw materials needs to be strictly controlled to assure end-product quality and enable the identification of the origin of defects caused by impurities or contamination. Six types of ceramic raw materials (silica sand, clays and kaolin, feldspars and related minerals, calcium and magnesium carbonates, sodium and calcium borates, and zirconium silicates) have been analysed in this study. X-ray fluorescence (XRF), potentiometry, coulometry and atomic absorption spectrometry (AAS) were used in this chemical characterisation. A methodology has been established for characterising each studied raw material, by identifying the chemical elements to be determined, selecting the most appropriate technique and validating each measurement. The reference materials used for validation were BCS CRM 267, 313/1, 393 and 388 (BAS), GBW 03103, GBW 07404, NIST SRM 181, 201a and 1835, Euronorm CRM 782-1 and Syenite SY-2. The results showed that most of the elements present in the geological samples used as traditional ceramic raw materials could be determined by XRF. The determination of light elements, such as lithium, fluorine and boron, is more suitably conducted by ICP-AES/AAS, potentiometry or potentiometry/ICP-AES respectively. Organic and inorganic carbon could be determined by coulometry. Inorganic carbon (CO2) could also be determined by coulometry or by thermogravimetry, if samples did not contain clay minerals. Loss on ignition was always determined by gravimetry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-908X.2004.tb00737.x
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  • 5
    Electronic Resource
    Electronic Resource
    EVALUATING THE COST-EFFECTIVENESS OF CLINICAL AND PUBLIC HEALTH MEASURES* (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 19 (1998), S. 125-152 
    Details
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Cost-effectiveness analysis, an analytic tool that expresses as a ratio the cost of obtaining an additional unit of health outcome, can help decision makers achieve more health protection for the same or less cost. We characterize the state of the cost-effectiveness analysis literature by reviewing how this technique is applied to various clinical and public health interventions. We describe the results of cost-effectiveness analyses for over 40 interventions to reduce cancer, heart disease, trauma, and infectious disease. The cost-effectiveness ratios for these interventions vary enormously, from interventions that save money to those that cost more than $1 million per year of life gained. The methods used to derive the cost-effectiveness ratios also vary considerably, and we summarize this variation within each health area. Greater uniformity of analytical practice will be necessary if cost-effectiveness analysis is to become a more influential tool in debates about resource allocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.publhealth.19.1.125
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  • 6
    Electronic Resource
    Electronic Resource
    Expression of glutamate transporters in rat optic nerve oligodendrocytes (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate the role of glutamate transport in non-synaptic glia, we characterized the expression of three major glutamate transporters (EAAC1, GLAST and GLT-1) in rat optic nerve in situ using reverse transcription-polymerase chain reaction in combination with Western blot and immunochemistry with specific antibodies. GLAST was localized to interfascicular oligodendrocytes, whereas a subpopulation of cells, probably immature oligodendrocyte cells, expressed EAAC1. In contrast, astrocytes, expressed only GLT-1, consistent with the idea that this is the major glutamate transporter in this cell type. In addition, we observed that glutamine synthetase, a key enzyme in glutamate metabolism, was localized in oligodendrocytes in situ. To examine the properties of these glutamate transporters, we conducted uptake experiments in glial cultures. The kinetics of sodium-dependent glutamate uptake in cultured oligodendrocytes from the perinatal rat optic nerve were markedly different from those observed in type-1 astrocytes from the newborn rat cerebral cortex, with higher affinity and lower Vmax. In both cell types, glutamate transport was inhibited by l-trans-pyrrolidine-2,4-dicarboxylate (t-PDC). In contrast, dihydrokainate exhibited significantly more uptake inhibition in oligodendrocytes than in type-1 astrocytes. These results provide evidence for the expression of functional sodium-dependent glutamate transporters in optic nerve oligodendrocytes, and suggest that this cell type may play a role in the glutamate–glutamine cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00639.x
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  • 7
    Electronic Resource
    Electronic Resource
    Changing profiles of injecting drug users with AIDS in a Hispanic population (2004)
    Oxford, UK : Blackwell Science Ltd
    Addiction 99 (2004), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Aims  To describe and assess the changing trends in socio-demographic, risk, clinical and immunological parameters in male intravenous drug users (IDU) with AIDS.Design, setting and participants  Baseline description by year of entry of 610 male IDU with AIDS who entered into a cohort study in Bayamón, Puerto Rico, from 1992 to 2000. Study participants were evaluated at in-patient health-care facilities in the University Hospital Ramón Ruiz Arnau or in the ambulatory immunology clinic facilities.Findings  The median age at which subjects entered the study and the proportion of patients with an educational level lower than a high school degree increased from 1992 to 2000. Upward trends were also observed in the practice of injecting non-prescription drugs during the last 12-month period, the practice of needle sharing and the use of a combination of heroin and cocaine (‘speedballs’). Higher proportions of subjects were also diagnosed with wasting syndrome and bacterial pneumonia. The median CD4 count recorded at entry decreased over the course of the study.Conclusions  Puerto Rican male IDU diagnosed with AIDS are arriving at health-care facilities in the latest stages of the disease. Better and early interventions with different health care approaches need to be developed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1360-0443.2004.00812.x
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  • 8
    Electronic Resource
    Electronic Resource
    Contact dermatitis from natural latex (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 27 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb03298.x
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  • 9
    Electronic Resource
    Electronic Resource
    Generalized dermatitis due to oral nystatin (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 25 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01835.x
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  • 10
    Electronic Resource
    Electronic Resource
    Gender wage gaps and job mobility in Spain (2004)
    Bingley : Emerald
    International journal of manpower 25 (2004), S. 264-278 
    Details
    ISSN: 0143-7720
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Equal treatment for men and women is an important objective of labour policy in the European Union, largely because there is ample evidence of gender discrimination in the wages of men and women, which are on an average higher for male workers. Research on male-female wage differentials provides evidence of a substantial wage differential favouring men after adjusting for human capital and personal characteristics such as education, age, job tenure, and labour force intermittency. However, few studies take into account the role that job mobility plays in this differential, despite its demonstrated importance in explaining the earnings profile of workers. This paper estimates gender wage differentials for workers who switch jobs and those who keep them in order to see whether job mobility enlarges or reduces the gender gap. The study uses microdata relative to Spanish workers gathered from the Households Panel Study (1994-1997), conducted by the Spanish National Statistics Institute.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/01437720410541399
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