ISSN:
1573-2568
Keywords:
undecalcified bone biopsy
;
bone histomorphometry
;
alcoholic hepatic cirrhosis
;
osteoporosis
;
hepatic osteodystrophy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Bone biopsies of 52 histologically confirmed alcoholic cirrhotic patients and 15 age- and sex-matched controls have been histomorphometrically analyzed determining trabecular bone volume (TBV), mineralized bone volume (MBV), and osteoid volume (OV). We also determined serum PTH, 25-OH-D3, calcitonin, FSH, LH, estradiol, testosterone, T3 and T4, urine cortisol, routine liver function tests, serum and urinary calcium, phosphorus, and magnesium. We found a high prevalence of osteoporosis: TBV was significantly lower in cirrhotic patients (T=7.23, P〈0.001), 41 of them being in the range of osteoporosis; none of them had osteomalacia. Levels of all the above-mentioned hormones and electrolytes were almost normal, and no correlation was found between them and liver function tests, as occurred with the bone parameters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01535783
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