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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic aspects of caffeine in premature infants with apnoea (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 47-52 
    Details
    ISSN: 1432-1041
    Keywords: apnoea ; caffeine ; premature infants ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of caffeine was examined in 13 premature infants (gestational age 25–34 weeks, birth weight 920–2060 g, postnatal age 1–42 days) who received the drug for treatment of opnoea. Caffeine (1% aqueous solution) was given i.v. in single doses; guided by the clinical response infants received between one and seven (mean 2.6) doses of 15 mg/kg. Mean (± SE; range) Clb was extremely slow − 8.5 ml/kg/h (±0.4; 5.8–12.2), t1/2 was prolonged − 65.0 h (±3.7; 48.2–87.5 h) and Vd was 0.781/kg (±0.04; 0.47–1.01). No significant correlation was found between Clb, t1/2 and postnatal age in the whole group or in individual infants. Effective plasma concentrations varied over a wide range (12–36 µg/ml) and overlapped with subtherapeutic concentrations (⩽24 µg/ml). Single doses of 15 mg/kg i.v. or p.o. prevented apnoea in most cases, if necessary followed by additional doses. Monitoring the blood level of caffeine in infants receiving frequent repeated doses is necessary to prevent toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606424
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  • 2
    Electronic Resource
    Electronic Resource
    Urinary metabolites of caffeine in the premature infant (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 497-499 
    Details
    ISSN: 1432-1041
    Keywords: caffeine ; prematurity ; infants ; 6-amino-5[N-methylamino] -1,3-dimethyluracil ; caffeine metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Caffeine metabolites in urine from premature infants were analysed by TLC and HPLC. Caffeine, dimethyluric acids, mono- and dimethylxanthines and, for the first time, a uracil derivative (6-amino-5-[N-methylformylamino]-1,3-dimethyluracil) were identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613531
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  • 3
    Electronic Resource
    Electronic Resource
    Intervertebral disc infection (Discitis) in childhood (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 66-70 
    Details
    ISSN: 1432-1076
    Keywords: Discitis ; Intervertebral disc infection ; Septic arthritis ; Osteomyelitis ; Back pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Discitis is an inflammatory process of the intervertebral disc space occurring in the pediatric age range. Its etiology is usually unknown; staphylococcus aureus is the most common microorganism present in the few cases with positive bacteriological cultures. The clinical presentation can mimic medical or surgical emergencies and thus unnecessary investigations or surgical procedures are frequently performed. Irritability, refusal to sit or walk, low grade fever, high erythrocyte sedimentation rate and normal leukocyte count are the most common clinical findings. The disease is usually self-limited and has a benign course. Awareness of the physician is the key for the diagnosis which can be established by nuclear imaging procedures and radiological studies, yet, this disease is not described in standard pediatric textbooks. Eight cases of discitis in children affecting the dorsal, lumbar and cervical spine were diagnosed and treated in two medical centers in Israel. The purpose of this report is to focus the attention of physicians caring for children on this entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442083
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Methaemoglobinaemia in young infants with diarrhoea (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 87-89 
    Details
    ISSN: 1432-1076
    Keywords: Methaemoglobinaemia ; Diarrhoea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventeen infants under 2 months of age are described who presented with methaemoglobinaemia and acute diarrhoea during a period of 2 years. No infants beyond this age presented with such characteristics. In none of them was one of the known mechanisms of methaemoglobin formation found. All infants recovered with conventional therapy. Methacmoglobin associated with diarrhoea relapsed in three infants before they were 2 months old. Twenty-six similar cases have been reported in the literature. The mechanism of methaemoglobinaemia in these infants is unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442620
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pasteurella ureae meningitis as complication of skull fractures (1985)
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 589-590 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of a six-year-old boy who developed meningitis three months after a skull fracture is reported. Blood and cerebrospinal fluid yieldedPasteurella ureae. A two-week intravenous course of ampicillin and chloramphenicol resulted in full recovery. Two of the other four cases ofPasteurella ureae meningitis reported in the literature occurred after skull fractures, and one after intracranial surgery. The child described here is the youngest reported patient with meningitis due to this rare pathogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013402
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    Paper (German National Licenses)
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