ISSN:
1433-0350
Keywords:
Key words Traumatic brain injury
;
Diffuse axonal injury
;
β-Amyloid precursor protein
;
Tolerance criteria
;
Motor vehicle accidents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract As part of a multidisciplinary study of brain damage in children fatally injured in motor vehicle accidents, a simple method to quantify and visualise the distribution and extent of injury has been developed. Vascular and axonal injury were assessed using coronal brain sections stained for haematoxylin and eosin, or reacted immunohistochemically for β-amyloid precursor protein. Subsequent analysis was carried out using NIH Image software, and the resulting information is displayed in schematic diagrams. These summary diagrams simply and clearly show the distribution of injury in both the coronal and horizontal planes. This technique offers an advantage over previous scoring methods in that it provides both a quantitative and a visual summary of the distribution and extent of brain injury. This information can then be used to compare the injury distribution and severity with estimated impact points and acceleration data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003810050403
Permalink
