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  • 1
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 16 (2005), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction: Gain-of-function mutations within Scn5a, including the ΔKPQ 1505-1507 deletion in the inactivation domain compromising myocardial repolarization, are implicated in human long QT 3 syndrome (LQT3), associated with ventricular arrhythmogenesis and sudden death. Methods and Results: Patch clamp studies on isolated ventricular Scn5a+/Δ myocytes from ΔKPQ mice produced by homologous recombination in embryonic stem (ES) cells confirmed such altered electrophysiological properties of the mutant channel. Programmed electrical stimulation (PES) with decremental pacing from the basal right ventricular epicardial surface and paced electrogram fractionation analysis (PEFA) of electrograms recorded from the basal left ventricular epicardial surface of Langendorff-perfused whole heart preparations demonstrated ventricular tachycardia (VT) in 8 of 9 Scn5a+/Δ mutant (but no Scn5a+/+ (wild-type (WT)) controls; n = 17), with increased electrogram durations (EGD) and more dispersed conduction curves. Isoproterenol (100 nM) was without effect on tachycardic Scn5a+/Δ hearts (n = 9) yet propranolol (1 μM) prevented VT in all isoproterenol-infused WT control (n = 4) but no Scn5a+/Δ hearts (n = 4). Furthermore propranolol itself increased EGD and dispersion in Scn5a+/Δ hearts. In contrast, mexiletine (10 μM) suppressed VTs in 4 of 5 Scn5a+/Δ hearts without altering EGD or dispersion. Conclusion:β-adrenoreceptor blockade does not confer an antiarrhythmic effect and may even enhance arrhythmogenesis by increasing reentrant substrate in Scn5a+/Δ hearts while mexiletine protects against VT without modifying conduction characteristics. Together these findings permit a scheme where VT in LQT3 is initiated by triggered mechanisms but propagated by reentry.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Multivariate analysis of 1H-NMR spectra of blood sera was reported previously to predict angiographically defined advanced coronary artery disease (CAD) with 〉90% accuracy and specificity. The analysis depended mainly on the major lipid regions of the spectra, but many variables, including ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Recent evidence has led us to propose that transforming growth factor-β (TGF-β) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less active TGF-β in their sera than patients with normal coronary arteries, with a ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5018 , USA . : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 26 (2003), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: LOWE, M.D., et al .: Catheter Cryoablation of Supraventricular Arrhythmias: A Painless Alternative to Radiofrequency Energy. Cryothermy has potential advantages over RF energy for catheter ablation, including reversibility of lesion formation, catheter stability, and less procedural discomfort. Cryoablation procedures were performed in 14 patients with atrioventricular reentrant tachycardias (AVNRTs), 13 patients with accessory pathway (AP)-mediated tachycardias, and 5 patients with atrial fibrillation. The numbers of energy applications, pain scores, procedural times, and outcomes were recorded and compared with age- and sex-matched patients undergoing similar RF procedures. Cryoablation was successful in 26 of 32 patients (11/14 AVNRT, 10/13 AP, 5/5 AF) compared with 30 of 32 undergoing RF procedures, with similar numbers of energy applications and procedural times. Cryothermy was painless in all patients, and the overall procedural discomfort was significantly less than in patients treated with RF (1.3 ± 2.2 vs 6.1 ± 3.5) . In patients with anteroseptal pathways, cryomapping successfully identified safe sites to target the delivery of energy. Cryothermy is a painless and safe alternative to RF. It may be particularly useful for catheter ablation of patients with pathways close to the atrioventricular node. (PACE 2003; 26[Pt. II]:500–503)
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5018 , U.S.A . : Blackwell Publishing
    Pacing and clinical electrophysiology 26 (2003), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to assess if atrial leads whose “J” configuration has straightened significantly on the postprocedural chest X ray should be repositioned. Between January 1996 and December 1997, 445 patients underwent dual chamber pacemaker implantation at the Papworth Hospital. Postprocedural chest X rays were available in 410 of these. The degree of straightening of the tip of the atrial lead was assessed from the lateral chest X ray and was graded as mild (−10 to +10 degrees from the horizontal), moderate (+10 to +30 degrees), or severe (≥+30 degrees). Patients were followed with regard to atrial sensing and pacing characteristics, lead displacements, and lead revisions. Fifty-two (12%) patients had some degree of straightening (graded mild, moderate, severe) of the atrial lead on the postprocedure chest X ray (passive fixation in 48, active 4). Of these, 12 patients underwent next day lead repositioning, 5 of whom had abnormalities of pacing and/or sensing parameters. Seven patients therefore underwent repositioning of the atrial lead despite normal pacing parameters in view of lead straightening alone. Of the 12 patients who underwent repositioning, 3 still had lead straightening after the second procedure. The cohort for follow-up consisted of 43 patients (24 [56%] men, age 69 ± 11 years at the time of implant) who were left with significant atrial lead straightening but adequate atrial parameters. Straightening was mild in 26 patients, moderate in 10, and severe in 7 patients. At implant the P wave amplitude was 4.8 ± 2.4 mV. Follow-up was for 4.8 ± 2.1 years, a total of 178 patient years. At final follow-up, the P wave amplitude was 2.7 ± 1.3 (P 〈 0.05 vs implant). Censoring events occurred in 16 cases, comprising 11 deaths (none suspected to be pacemaker or lead related), 3 cases of persistent atrial fibrillation, 1 system extraction for infection, and 1 lead extraction for erosion. There were no cases of inadequate atrial lead sensing or pacing in the remaining patients. Irrespective of the degree of lead straightening on the postoperative lateral chest X ray, atrial leads should not be repositioned unless there are abnormalities of pacing or sensing parameters. (PACE 2003; 26:2142–2145)
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 21 (1998), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cannulation of the coronary sinus is a common procedure with infrequent complications. We report an unusual case of a steerable “dumb-bell” catheter passed through the ostium of the coronary sinus prior to an intended radiofrequency ablation procedure becoming stuck and requiring general anesthesia for extraction. We caution against the use of such catheters with a “waist” for the cannulation of the coronary sinus.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 359 (1999), S. 400-403 
    ISSN: 1432-1912
    Keywords: Key words Ferret heart tissues ; β1- and putative ; β4-adrenoceptors* Carvedilol ; ( ; )-Isoprenaline ; (±)-CGP 12177
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The putative β4-adrenoceptor mediates positive inotropic effects, action potential shortening and arrhythmias in ferret ventricle. Here we compared the affinity of carvedilol at the putative β4-adrenoceptor and β1-adrenoceptor, activated by (±)-CGP 12177 and (–)-isoprenaline, respectively. In paced right ventricular preparations, carvedilol (0.01–10 μmol/l) was a simple competitive antagonist of the positive inotropic effects of (±)-CGP 12177 (slope of Schild-plot = 1.02, pK B = 6.8) and (–)-isoprenaline (slope of Schild-plot = 0.98, pK B = 8.1). Carvedilol also blocked putative β4- and β1-adrenoceptors of left ventricle, left atrium and sino-atrial pacemaker. Carvedilol therefore interacts with the putative β4-adrenoceptor according to the law of mass action and may provide a lead in the development of putative β4-adrenoceptor-selective antagonists.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cardiac electrophysiology review 2 (1998), S. 207-210 
    ISSN: 1573-725X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cardiac electrophysiology review 4 (2000), S. 292-295 
    ISSN: 1573-725X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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