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  • 1
    Electronic Resource
    Electronic Resource
    Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 316-320 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is known that pain perception can be altered by mood, attention and cognition, or by direct stimulation of the cerebral cortex, but we know little of the neural mechanisms underlying the cortical modulation of pain. One of the few cortical areas consistently activated by painful stimuli is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01808
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multifaceted alterations of the thalamo-cortico-thalamic loop in adult rats prenatally exposed to ethanol (1995)
    Springer
    Anatomy and embryology 191 (1995), S. 11-23 
    Details
    ISSN: 1432-0568
    Keywords: Fetal alcohol syndrome ; Intralaminar nuclei ; Thalamic midline ; Sensori-motor cortex Axon terminals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The thalamo-cortico-thalamic loop was investigated in adult rats exposed to ethanol during the last week of fetal life. Animals underwent either cortical or thalamic injections of lectin-conjugated horseradish peroxidase. Results demonstrate that prenatal exposure to ethanol causes permanent changes in the thalamocortical circuits. Alterations of thalamo-cortical and cortico-thalamic projections are concentrated at the level of axon terminal fields. The most severe thalamic damage is observed in the anterior intralaminar and midline nuclei; crossed cortico-thalamic projections also appear to be severely impaired. In the cortex, the damage to thalamic terminals displays a medio-lateral gradient of increasing severity through sensori-motor areas, with the lateral fields more impaired. Cells of origin of thalamo-cortical and cortico-thalamic projections are less affected by prenatal ethanol exposure: in the thalamus and layer 5 of sensori-motor cortex labeled cells exhibit normal values of areal numeric density. Conversely, cortico-thalamic neurons of layer 6, especially in the lateral agranular sensori-motor field, display smaller values of areal density than those of normal animals. Possible mechanisms underlying the establishment of these abnormalities are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215293
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Organization of callosal connections in rats with experimentally induced microgyria (1999)
    Springer
    Child's nervous system 15 (1999), S. 444-448 
    Details
    ISSN: 1433-0350
    Keywords: Key words Microgyria ; Corpus callosum ; Peroxidase ; Development ; Cerebral cortex ; Dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The anatomical organization of projections from the microgyric cortex to the contralateral hemisphere through the corpus callosum has been studied in the rat. Microgyria was induced on the first postnatal day by a freezing injury. Once adult, animals received injections of horseradish peroxidase in the cortex contralateral to the lesion. Callosally projecting neurons located in the normally layered cortex adjoining the focal lesion showed a different laminar distribution from that observed in control animals. The highest percentage of callosal neurons was found in layer 6 in lesioned animals, whereas layers 2/3 and 5 gave rise to most of interhemispheric projections in controls. Possible mechanisms leading to the establishment of aberrant callosal connections and potential implications for the human pathology are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050435
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    Paper (German National Licenses)
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