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  • 1
    Electronic Resource
    Electronic Resource
    Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma (1983)
    Springer
    Cancer chemotherapy and pharmacology 11 (1983), S. 38-42 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antitumor activity and toxic effect of AMSA were studied in Lewis lung carcinoma (3LL) at various stages of growth. The total dose of drug injected IP was 15 mg/kg, which is equivalent to the LD10. Different administration schedules were tested, these being single-injection schedules (day 1, 7, or 10 after tumor implantation) and repeated low-dose-injection regimens (days 1, 4, and 7 and days 1–7 after tumor implantation). Tumor weight inhibition, retardation of growth, reduction in the number of metastases, and median survival time of treated mice over controls were analyzed as end-points to evaluate the antitumor activity of AMSA. Early deaths and changes in white blood cell count were considered as parameters of toxicity. Our findings can be summarized as follows: (1) AMSA is only minimally effective against primary 3LL tumor at all the growth stages examined and no schedule-dependency is detected; (2) a greater reduction in metastases (70%–77%) is found when the drug is administered fractionally than when it is given in a single dose (39%–60%); (3) irreversible leukopenia is induced by the single-dose schedule of AMSA administration while after repeated low doses the white blood cell counts are in the same range of those of the control groups. Therefore, because of the schedule-dependency of toxicity and reduction in metastases, fractionated administration of AMSA at this dose level would be suitable for adjuvant chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257415
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  • 2
    Electronic Resource
    Electronic Resource
    Establishment of cell lines from serial samples from two patients with lung tumours before and after chemotherapy (1989)
    Springer
    Cytotechnology 2 (1989), S. 39-47 
    Details
    ISSN: 1573-0778
    Keywords: antimetabolic assay ; drug resistance ; in vitro model ; non small cell lung cancer ; small cell lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Six cell lines were derived from pleural effusions of two lung cancer patients and established in vitro in our laboratory. Cell line AE1 was obtained from a small cell lung cancer (SCLC) before the patient had received any chemotherapy; the other lines (AE2 and AE3) were established from tumour recurrences in the same patient after therapy. Cell lines DG1 and DG2 were derived from specimens of an untreated non-small cell lung cancer (NSCLC), while cell line DG3 originated from pleural effusions recurring in the same patient after therapy. The results of the present study show that: (a) the SCLC lines AE1, AE2 and AE3 are heterogeneous in their biological characteristics and in their chemosensitivity patterns. In particular lines AE2 and AE3 are less responsive to cis-Platinum (DDP) and Adriamycin (ADM) than line AE1, so that they may reflect resistant subpopulations existing within the original tumour, selected following therapy with these drugs. In contrast, however, line AE1 proved more resistant to Vepesid (VP16) than lines AE2 and AE3. (b) The three NSCLC lines are similar in various biological features as well as in their chemosensitivity to DDP and Vinblastine (VBL).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365413
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Establishment, characterization and chemosensitivity of two human glioma derived cell lines (1988)
    Springer
    Journal of neuro-oncology 6 (1988), S. 169-177 
    Details
    ISSN: 1573-7373
    Keywords: cell lines ; gliomas ; chemosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two continuous human glioma derived cell lines, LI and DF, were established in our laboratory. Both cell lines showed cytological features andin vitro behavior similar to those of the respective original neoplasms. These two lines were characterized for their main biological properties includingin vitro andin vivo growth rate, clonogenic ability and tumorigenicity in nude mice. The plating efficiencies were generally high both during exponential and stationary growth phases and a high tumorigenicity was observed. All injected nude mice developed tumors. The two lines were tested for chemosensitivity to 1,3-bis(2-chloroethyl)-1-1nitrosourea (BCNU) and cis-Diamminedichloroplatinum II (DDP). Heterogeneity in biological features and in drug sensitivity was observed. Exposure of the two lines to BCNU and DDP showed that the glioblastoma (LI) was less sensitive than the anaplastic astrocytoma (DF). For both lines BCNU was more effective on cells in plateau than in exponential phase, while the killing effect of DDP was not phase-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327393
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    Paper (German National Licenses)
    Fulltext
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