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  • 1
    Electronic Resource
    Electronic Resource
    Free perforation due to cancer in Crohn's disease (1987)
    Springer
    International journal of colorectal disease 2 (1987), S. 201-202 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Free perforation of cancer in Crohn's disease is exceedingly rare. Three cases were found among 1010 patients admitted to Mount Sinai Hospital between 1960 and 1980. Free perforation of cancer occurs late in the course of Crohn's disease between the second and third decades of disease, whereas spontaneous free perforation usually occurs within the first 5 years. Cancer-related perforation is associated with weight loss, mass and fistula, and carries a poor prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649505
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The role oxygen free radicals and prostaglandins in reperfusion injury to warm ischemic kidneys (1991)
    Springer
    Urological research 19 (1991), S. 393-395 
    Details
    ISSN: 1434-0879
    Keywords: Renal failure ; Reperfusion renal injury ; Oxygen free radicals ; Prostaglandins ; Superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was designed to determine whether the administration of superoxide dismutase (SOD) can alleviate ischemic kidney damage and whether there is a relationship between oxygen free radicals and thromboxane (Tx). In 17 dogs, the right kidney was removed and the vascular pedicle of the left kidney was clamped for 75 min. Prior to reperfusion, the ischemic kidney was rinsed with 5 mg SOD and an additional 20 mg SOD was infused systemically. Blood samples were drawn from the renal vein before ischemia and after reperfusion to determine serum levels of thromboxane B2 (TxB2). All eight untreated dogs died within 1 week of renal failure, and the nine treated dogs demonstrated transient renal failure, with a significant difference (P〈0.001) being found between the two groups. A significant difference (P〈0.001) in TxB2 levels was found in the untreated dogs before and after ischemia and beween the two groups following reperfusion. Animals that are treated with SOD after the ischemic event has occured but before reperfusion exhibit a favorable clinical course in terms of survival and renal function. Tx synthesis in the kidney can be blocked by the administration of SOD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310157
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of peripheral blood T-cell subpopulation of bladder cancer patients (1991)
    Springer
    Urological research 19 (1991), S. 219-222 
    Details
    ISSN: 1434-0879
    Keywords: Bladder cancer ; Peripheral blood T-lymphocytes ; Immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The levels of immune reactivity of peripheral and blood T-lymphocytes were evaluated in 37 bladder cancer patients and 31 age-matched controls. T-lymphocyte subsets were quantified by monoclonal antibodies, and the immune reactivity was measured using stimulation with phytohemagglutinin (PHA), concanavalin A (ConA), and pokeweed mitogen (PWM). Comparing the patients before and after treatment revealed significant changes in the stimulation index of proliferative response to PHA, PWM, in the PWM% (the patient response compared to the control), and in the percent of T8 cells from the total count of blood lymphocytes. Further significant differences were found among the disease stages in the numbers of T3, T4 lymphocytes subpopulations and the total lymphocyte count. A significant interaction was found between the treatment and patient's sex regarding the T4:T8 ratio.Also, a higher prevalence of T4:T8〈1 was found among the patients compared to the controls before and after treatment regardless of the disease stage. This T4:T8〈1 ratio can serve as an indicator of immune competence in bladder transitional cell carcinoma patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305298
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  • 4
    Electronic Resource
    Electronic Resource
    Perinuclear anti-neutrophil cytoplasmic antibody and refractory pouchitis (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 1866-1872 
    Details
    ISSN: 1573-2568
    Keywords: pouchitis ; ANCA ; ulcerative colitis ; extraintestinal manifestations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Refractory pouchitis (RP) is a debilitating complication of ileal pouch reservoirs that affects hypothesized that it reflects underlying Crohn's disease. Since perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is found in approximately 70% of ulcerative colitis patients but only rarely in Crohn's disease patients, it may help distinguish Crohn's disease from ulcerative colitis. Therefore, to test whether RP reflects “missed” Crohn's disease, we determined the ANCA status of 26 patients with RP. The pANCA was positive in 42% of cases [50% of Kock pouch cases and 33% of ileoanal pull-through (IAPT) cases] and 57% of matched control subjects without pouchitis (N=42,P=NS). Moreover, 3/6 (50%) of IAPT RP subjects whose signs and symptoms most suggested Crohn's disease tested positive for pANCA. When compared to controls, IAPT cases exhibited significantly more preoperative extraintestinal manifestations (EIMs) of inflammatory bowel disease (P〈0.05). The presence of preoperative EIMs was 100% predictive of postoperative EIMs (P〈0.05). Review of pouch biopsies from cases of RP revealed no pathognomonic histologic features of Crohn's disease. These data confirm our previous suggestion that RP does not reflect underlying Crohn's disease but may be associated with the EIMs of inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208648
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  • 5
    Electronic Resource
    Electronic Resource
    Leder, Gerberei (1938)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 114 (1938), S. 310-319 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01396605
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    Paper (German National Licenses)
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