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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Injecting fibrin glue has proved to be an effective means of treating anal fistulas (AF). There has been some debate, however, as to whether this technique should be used on the AF often involved in Crohn's disease (CD).Aim : To assess the effectiveness of injecting heterologous fibrin glue as a means of treating AF refractory to immunosuppressive treatment in patients with CD.Methods : Fourteen CD patients (five men and nine women, average age 42 years) presenting with refractory AFs were included in this study. Heterologous fibrin glue was injected into the fistula tract under general anaesthesia under continuous endosonographic monitoring using a 7.5-MHz blind linear probe. The patients were followed up clinically and ultrasonographically for 3 months after the procedure, and then at regular intervals.Results : Three months after the fibrin glue injection, the fistulas had completely dried up in 10 patients (71%), the leakage had decreased in one patient (7%), and no improvement was observed in the other three patients (21%). Endosonographic findings showed that the fistula tract had completely disappeared in two cases (14%). The fistula tract was found to be non-permeable in eight cases (57%), and no change in the fistula was observed in four patients (29%). At the end of the follow-up period [average 23.4 months (12–26 months)], the leakage had completely dried up in eight of the 14 patients (57%). No side effects were observed.Conclusion : Nearly 2 years after the use of a heterologous fibrin glue to treat an AF, over half of the patients with CD showed clinical signs of remission. Because it is easy to use and harmless as well as being effective, this method provides a good alternative to classical methods of surgical treatment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A previous study has suggested that Bifidobacterium animalis DN-173 010 shortens the colonic transit time in women.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To confirm this effect and to determine whether modifications of the faecal bacterial mass and/or faecal secondary bile salts may be the explanation.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:A double-blind, cross-over study was performed. Thirty-six healthy women were studied in four consecutive 10-day periods. During periods 2 and 4, they ingested three 125 g cups per day of a fermented milk which was either a product containing B. animalis DN-173 010 or a control without bifidobacteria. Periods 1 and 3 were run-in and washout periods, respectively. The total and segmental colonic transit times were assessed using a pellet method. In 12 subjects, all stools were collected and analysed for pH, faecal weight, bacterial mass and bile acids.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The total and sigmoid transit times were significantly shorter during dosing with B. animalis compared to the control period. The other transit times, faecal weight, pH, bacterial mass and bile acids were not significantly affected.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions: B. animalis DN-173 010 shortens the colonic transit time in healthy women. This effect is not explained by modifications of the faecal bacterial mass or secondary bile acids.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 258 (1987), S. 77-84 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Le but de cette étude est d'analyser la corti-nence fécale postopératoire à l'aide d'un suivi clinique et d'études manométriques chez 10 patients atteints de colite ulcéreuse ayant subi une procto-colectomie totale avec anastomose iléo-anale par double agrafage conservant la zone de transition. Une étude histologique annuelle a été réalisée sur la zone de transition en postopératoire. Une diminution de 13% de la longueur de la zone de haute pression du canal (P = 0,04) a été observée sans que ceci n'en-traîne de changement significatif dans la pression anale de repos ou dans la valeur de la contraction maximale volontaire. Cinquante pour-cent des patients ont montré des signes histologiques d'inflammation sans que ceci n'ait de répercussions cliniques. Le nombre moyen d'exonérations quotidiennes étaient de 4 par jour et une par nuit; seul un patient présentait, de manière épisodique, des fuites nocturnes (moins d'une par semaine). A l'interrogatoire, neuf patients ont répondu qu'ils estimaient leur continence comme très bonne ou bonne et un patient comme suffisante. Ces constatations montrent que l'anastomose iléo-anale sans résection de la muqueuse permet de maintenir une pression anale de repos normale et des fonctions anales satisfaisantes malgré la réduction de la zone de haute pression.
    Notes: Abstract. The aim of this prospective study was to analyse post-operative faecal continence by carrying out a manometric and clinical follow-up on ten patients previously suffering from ulcerative colitis, who underwent total proctocolectomy and double-stapled ileo-anal anastomosis with preservation of the transitional zone. An annual histological analysis of the transitional zone was performed post-operatively. A 13% reduction in the length of the high-pressure zone of the anal canal (P = 0.04) was observed without any significant change in the resting anal pressure or the maximal squeeze pressures. Fifty percent of the patients showed histological signs of inflammation, without any clinical manifestations. The median number of bowel movements was 4 per day and 1 per night, and only 1 patient had occasional nocturnal soiling (less than once a week). On being questioned, 9 patients replied that they rated their continence as good or very good and 1 patient, as reasonable. These findings show that ileo-anal anastomosis, without mucosal resection preserves the normal resting anal pressure and anal function despite the reduction in the length of the high pressure zone it involves.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 4 (1990), S. 122-123 
    ISSN: 1432-2218
    Keywords: Primary malignant melanoma ; Esophagus ; Endoscopy ; Endoscopic ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes a case of primary malignant melanoma of the esophagus in a 66-year-old man treated by esophagogastrectomy. Radiographic, endoscopic, echoendoscopic and histological features are given and a short review of the literature is presented.
    Type of Medium: Electronic Resource
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