ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract 1,2-Dihydroimidazo[4,5,1-n,m]phenothiazine-1-thione (III) was synthesized by the reaction of 1-aminophenothiazine (II) with sulfur and carbon disulfide or potassium ethylxanthogenate. The oxidation of III with hydrogen peroxide in alkali and acid media leads to imidazo-[4,5,1-n,m]phenothiazine (I) and imidazo[4,5,1-n,m]phenothiazine 6,6-dioxide (VI), respectively. Several S-alkyl and S-aralkyl derivatives of in (IVa-d) were obtained by the action of alkyl and aralkyl halides; the oxidation of IVa-d in acetic acid gave 1,2-dihydroimidazo-[4,5,1-n,m]-1-phenothiazone 6,6-dioxide (VII).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00476816
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