Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 344 (1978), S. 281-291 
    ISSN: 1435-2451
    Keywords: Breast ; Carcinoma ; Morphology ; Operation ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Frage der Notwendigkeit eines radikalen operativen Vorgehens beim Mammacarcinom in Anlehnung an die Halsted-Methode wird versucht, anhand der Häufigkeit von Carcinomrestgewebe in der amputierten Mamma nach vorausgegangener Probeexcision und anhand der Häufigkeit regionaler Lymphknotenmetastasen Stellung zu nehmen. Zur Auswertung kam das Gewebe von 600 Frauen im Alter von 27–86 Jahren (Durchschnittsalter 58 Jahre), welches im Zeitraum von 1969-1974 am Pathologischen Institut der Universität München untersucht worden ist. Aufgrund der morphologischen Befunde allein, also ohne Kenntnis der klinischen Stadieneinteilung, ergibt sichim Nachhinein, daß in 36% eine großzügige lokale Tumorexstirpation (en bloc-Resektion), in 21 % eine einfache Mastektomie und in 17 % eine einfache Mastektomie mit zusätzlicher Ausräumung der axillären Lymphknoten ausreichend gewesen wäre. In einem Viertel der Fälle ist in der Tat aber erst mit einer radikalen Mastektomie das Tumorgewebe entfernt gewesen. Diese Auswertungen, allein gewonnen auf dem Boden morphologischer Befunde, müssen aber solange lediglich als Denkmodell im Raum stehenbleiben, solange die derzeitigen diagnostischen Methoden nicht ausreichen, eine exakte, d. h. zweifelsfreie Abgrenzung des bösartigen Geschwulstprozesses prä- oder intraoperativ zu gewährleisten. Grundsätzlich wird weiterhin bei gesichertem Mammacarcinom das Organerhaltende operative Vorgehen dem Einzelfall, mit der Stimme der Patientin, vorbehalten bleiben müssen, da im Mittel das Risiko eines Rezidivs infolge unvollständiger Tumorerfassung bei der Erstoperation zu hoch ist.
    Notes: Summary This study is an attempt to evaluate the necessity of radical surgery based on the incidence of tumor remnants and lymphnode metastases in amputated breast after diagnostic excision. The material included 600 female patients, from 27–86 years old (mean age 58 years) examined at the Institute of Pathology University of Munich between 1969 and 1974. Retrospectively 36% of the specimen would have been free of tumor after en bloc resection, 21% simple mastectomy and 19% after simple mastectomy with additional axillary lymphnode disection. In fact, however, radical mastectomy was necessary in 25% for total removal of the tumor. As no methods for exact preoperative determination of tumor extension are yet known and as there is a high risk of recurrant tumor because of insufficient excision, organ-preserving surgical procedures still will be restricted to a few individual and selected cases of breast carcinoma presuming the patients consent.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 14 (1998), S. 431-442 
    ISSN: 0749-503X
    Keywords: differential display ; S.cerevisiae ; thermotolerance ; repression ; derepression ; gene regulation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have described the use of differential display of PCR-amplified reverse transcribed mRNA (DDRT-PCR) to survey changes in gene expression profiles induced by heat shock and carbon catabolite derepression in Saccharomyces cerevisiae. It is well established that either of these states elicits thermotolerant phenotypes. An initial analysis conducted on cells of an inherently thermosensitive strain (Ysen) indicated that approximately 10% of the total number of cDNAs detected were either up or down regulated following heat shock at 37°C (30 min) in comparison to control cells (25°C). In addition, whereas 7% of all PCR products were preferentially expressed during derepressive growth, approximately 2% were found to be common to both heat-shocked and derepressed cells. A repeat analysis, performed on all three cell types of Ysen as well as cells of a relatively thermoresistant strain (Yres) yielded 30 differentially displayed cDNA fragments common to heat-shocked and derepressed cells of both strains. Eighteen of these generated signals on Northern blots, of which three were confirmed as regulated. Five amplicons, including one not detected by Northern analysis and another from the derepressed state, were cloned and sequenced. Three of these exhibited homology to S. cerevisiae genes with well-characterized protein products: HSP 90, HXK1and STA1. The remaining two applicons showed nucleotide identity to YTIS11, a homolog of the mammalian TIS11 and putative transcriptional activator, and an orphan gene encoding a hypothetical transmembrane protein belonging to the multi-drug resistance translocase family. Our novel application of DDRT-PCR has identified new and known genes that may be further evaluated as factors involved in stress regulation and has demonstrated the potential of the technique to systematically analyse gene expression in yeast. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...