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  • 1
    Electronic Resource
    Electronic Resource
    Tilted n-fold symmetric radio frequency pulse sequences: Applications to CSA and heteronuclear dipolar recoupling in homonuclear dipolar coupled spin networks (1998)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 108 (1998), S. 7286-7293 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We describe new solid-state NMR methods for measuring the magnitude of the chemical shift anisotropy (CSA) and/or the heteronuclear dipolar coupling in the presence of homonuclear dipolar coupled spin networks under magic-angle spinning (MAS). The techniques employ 2π/5 phase shifts of a frequency switched Lee–Goldburg irradiation scheme which recouples the CSA and/or the heteronuclear dipolar coupling while simultaneously decoupling the homonuclear dipolar interactions. The induced spin dynamics are sensitive to the magnitude of the CSA and its asymmetry and may be implemented under conditions where the MAS rate exceeds the size of the anisotropic interactions. These approaches could find use in measurements of the magnitudes and relative orientations of CSA and/or heteronuclear dipolar couplings to extract torsion angles in uniformly labeled systems. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.476146
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  • 2
    Electronic Resource
    Electronic Resource
    Vacuolar H+-ATPase and weak base action in Dictyostelium (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 22 (1996), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Amoebae of Dictyostelium discoideum release ammonia during development, and the accumulation of this weak base is believed to be responsible for inhibiting fruiting-body formation and switching aggregates into migrating slugs. Exposure to weak bases can also inhibit aggregation and cell-type specific gene expression. The pathway by which weak bases influence development is not understood. We show here that the development of a set of mutants defective in acidification of intracellular acidic compartments is abnormally sensitive to inhibition by weak bases. Moreover even in the absence of added weak bases these mutants are delayed in aggregation and have a protracted migratory phase. The same behaviour is observed in trans-formants harbouring an antisense construct for one of the vacuolar H+-ATPase subunits. These results support the idea that weak bases exert their effects by inhibiting acidification of an intracellular acidic compartment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1996.tb02661.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cell differentiation without morphogenesis in Dictyostelium discoideum (1976)
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 717-719 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Bonner2 reported that a proportion of amoebae of strain NC4 developed into large vacuolated stalk-like cells when plated on agar containing 1 mM cyclic AMP at cell densities that were too low to allow aggregation in controls without cyclic AMP. This observation was extended by Chia3 who showed that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/262717a0
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  • 4
    Electronic Resource
    Electronic Resource
    Intracellular p H and the control of cell differentiation in Dictyostelium discoideum (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 244-245 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To test for the presence of an inhibitor of stalk cell differentiation, aliquots of conditioned medium freed of DIF were added to amoebae of strain VI2 M2, or of its sporogenous derivative, HM18, and the amoebae incubated at densities where they produce sufficient DIF to form substantial numbers of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303244a0
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  • 5
    Electronic Resource
    Electronic Resource
    Intracellular p H and the control of cell differentiation in Dictyostelium discoideum (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 244-245 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To test for the presence of an inhibitor of stalk cell differentiation, aliquots of conditioned medium freed of DIF were added to amoebae of strain VI2 M2, or of its sporogenous derivative, HM18, and the amoebae incubated at densities where they produce sufficient DIF to form substantial numbers of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303244a0
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The role of calcium in aggregation and development ofDictyostelium (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 1155-1165 
    Details
    ISSN: 1420-9071
    Keywords: ATPase ; cAMP ; calcium pools ; cGMP ; oscillation ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Changes in cytosolic Ca2+ play an important role in a wide array of cell types and the control of its concentration depends upon the interplay of many cellular constituents. Resting cells maintain cytosolic calcium ([Ca2+]i) at a low level in the face of steep gradients of extracellular and sequestered Ca2+. Many different signals can provoke the opening of calcium channels in the plasma membrane or in intracellular compartments and cause rapid influx of Ca2+ into the cytosol and elevation of [Ca2+]i. After such stimulation Ca2+ ATPases located in the plasma membrane and in the membranes of intracellular stores rapidly return [Ca2+]i to its basal level. Such responses to elevation of [Ca2+]i are a part of an important signal transduction mechanism that uses calcium (often via the binding protein calmodulin) to mediate a variety of cellular actions responsive to outside influences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944733
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