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  • 1
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In Parkinson's disease, poor motor performance (resulting primarily from abnormal cortical activation during movement preparation and execution) may also be due to impaired sensorimotor integration and defective cortical activity termination of the ongoing movement, thus delaying preparation of the following one. Reduced movement-related synchronization of the beta rhythm in Parkinson's disease compared to controls has been put forward as evidence for impaired postmovement cortical deactivation. We assessed the effects of subthalamic deep brain stimulation and l-dopa on beta rhythm synchronization over the premotor and primary sensorimotor cortex. Ten advanced patients performed self-paced wrist flexion in four conditions according to the presence or not of stimulation and l-dopa. Compared to without treatment, the motor score improved by ≈ 60%; the beta synchronization was present over the contralateral frontocentral region and increased significantly over the contralateral central region under stimulation and under l-dopa, with a maximal effect when both treatments were associated. Our advanced patients displayed very focused and attenuated beta rhythm synchronization which, under stimulation, increased over the contralateral premotor and primary sensorimotor cortex. Stimulation and l-dopa both partly restored postmovement cortical deactivation in advanced Parkinson's disease, although the respective mechanisms probably differ. They may improve bradykinesia and cortical deactivation by reestablishing movement-related somatosensory processing at the end of the movement through the basal ganglia into the cortex.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 65 (1982), S. 183-191 
    ISSN: 0942-0940
    Keywords: Halo device ; cervical spine lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the United States, cervical spine injuries are routinely immobilized with the halo apparatus. In Europe, this device is seldom used except in the treatment of spinal deviations. Based on studies of five cases the authors discuss the indications for use of the halo device in cervical spine injuries.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 384 (1980), S. 103-104 
    ISSN: 1432-2013
    Keywords: Fever ; Chill sensation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seven men were almost totally immersed in water at a neutral temperature (34.5o) and given an intravenous injection of exogenous pyrogen. Five subjects who exhibited fever and visible shivering all reported sensations of chill at the time of shivering. Two subjects who did not shiver reported neutral sensation throughout. The results indicate that reduction of skin temperature is not necessary for the chill sensation in fever. The chill must arise from some central action of pyrogen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 335 (1972), S. 97-108 
    ISSN: 1432-2013
    Keywords: Circadian Rhythm ; Thermal Balance ; Metabolism ; Rectal Temperature ; Skin Temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Evaporative, radiant and convective heat losses, metabolism and heat storage were determined on 8 unclothed reclining fasting subjects during 24 h in a climatic chamber maintained at a strictly constant and neutral temperature. In these conditions, a basal evolution of the body heat content and the rectal temperature were observed with nearly a disappearance of the diurnal thermal increase but persistency of a nocturnal falling followed by an early moring increase. Nocturnal cooling could be linked essentially with a rising skin temperature very likely through skin vasodilatation. Thus, the increase in radiant and convective heat losses was initially, constantly and predominantly involved for cooling the body in the evening and at night. The part played by the various skin areas was variable with the time, hands and feet temperature varying paradoxically in an opposite way to temperatures in other skin areas. Effects of an increase in evaporation and a decrease in basal metabolic rate were added later on but less systematically. It is proposed that sweating acts significantly only when thermal body state passes beyond the basal level. As this overpassing is essentially a function of metabolism, these two factors, metabolism and sweating seem to be tied in the mechanism controlling the body temperature rhythm. Body temperature is increased in the morning, principally by an increase in metabolism and a decrease in radiation and convection heat losses.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Motor evoked potentials ; Magnetic stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Magnetic stimulation of the brain and cervical and lumbar spinal roots was performed on 50 healthy volunteers. Compound muscle action potentials (CMAPs) were recorded from biceps brachii, abductor digiti minimi (ADM), rectus femoris and tibiahs anterior (TA). We assessed central conduction times by subtraction of peripheral from central latencies and compared results using either spinal root stimulation or the F-wave method. Side-to-side differences of total conduction time, peripheral conduction time and central conduction time (CCT) were measured and the effect of clockwise vs counterclockwise stimulations on latencies and sizes of CMAPs is emphasized. Amplitudes and areas of CMAPs were expressed as a percentage of the peripheral M response for ADM and TA. There was a positive correlation between CCT to the lumbosacral region and height, but not between the cervical region and height. No correlation was observed between genders and central conduction times, amplitudes or areas of CMAPs.
    Type of Medium: Electronic Resource
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