Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 26 (1997), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Odontogenic Myxoma — Clinical Concept and Morphological Studies (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 6 (1977), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Our experience with the odontogenic myxoma of the mandible is presented. Although it is a benign, slow growing neoplasm, it is locally aggressive. Patients rarely complain of any symptoms produced by this tumor. Morphological studies included enzyme histochemistry, as well as light and electron microscopy. Two major types of tumor cells were identified. One resembled a mature fibroblast, while the other had the morphological and functional criteria of a so-called myxoblast. We would recommend therapy comprising wide resection and consecutive primary osteoplasty.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1977.tb01800.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Odontogene Tumoren (2000)
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. S187 
    Details
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Odontogene Tumoren ; Symptome ; Klassifikation ; Therapiekonzept ; Key words ; Odontogenic tumors ; Symptoms ; Classification ; Therapeutic regime
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The clinical symptoms of odontogenic tumors are non-specific. On the roentgenographs one most often sees radiolucencies within the bone, sometimes in combination with scattered or diffuse radioopacities. Root resorptions may be another important feature. After a short historical introduction on the development of today’s classification of odontogenic tumors (WHO), each individual type of neoplasm is discussed briefly. Out of this, a therapeutic regime is developed that places each of the 22 entities into one of the following four groups: malignant, locally aggressive, tumors with recurrences, and non-recurrent ones.
    Notes: Zusammenfassung Die Symptome odontogener Tumoren sind meist unspezifisch. Röntgenologisch sind häufig nur Aufhellungen im Knochen, manchmal auch vereinzelte oder diffuse Radioopazitäten erkennbar. Wurzelspitzenresorptionen können ein weiterer wichtiger Befund sein. Nach kurzem historischem Abriss wird aufbauend auf der zurzeit gültigen WHO-Klassifikation kurz bei jedem einzelnen Typ über den aktuellen Wissensstand referiert. Daraus wird dann das heute gültige Therapiekonzept entwickelt, in dem alle 22 Tumorentitäten in insgesamt 4 Gruppen eingeteilt werden: maligne, lokal aggressive, rezidivfreudige und nicht-rezidivierende Tumoren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014540
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...