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  • 1
    Electronic Resource
    Electronic Resource
    238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Scientific Publications
    International journal of gynecological cancer 3 (1993), S. 0 
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty-two serous and mucinous ovarian tumors, an admixture of benign, borderline and malignant neoplasms, were immunostained for proliferating cell nuclear antigen (PCNA), with the monoclonal antibody PC10. The PC10 index, the proportion of cells showing nuclear positive staining, was calculated in each case. All the tumors showed positive immunoreactivity for PCNA. There was no overlap of PC10 counts between benign, borderline and malignant serous tumors but within the mucinous group of neoplasms there was considerable overlap between the counts for borderline and malignant tumors. There was no relationship between the PC10 index and the surgical stage of the malignant neoplasms and the index could not be correlated with patient death. Staining for PCNA does not, therefore, appear to be of any prognostic value in ovarian adenocarcinomas.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of chemical information and modeling 30 (1990), S. 256-263 
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 44 (2004), S. 399-421 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: New cells are continuously generated from immature proliferating cells throughout adulthood in many organs, thereby contributing to the integrity of the tissue under physiological conditions and to repair following injury. In contrast, repair mechanisms in the adult central nervous system (CNS) have long been thought to be very limited. However, recent findings have clearly demonstrated that in restricted areas of the mammalian brain, new functional neurons are constantly generated from neural stem cells throughout life. Moreover, stem cells with the potential to give rise to new neurons reside in many different regions of the adult CNS. These findings raise the possibility that endogenous neural stem cells can be mobilized to replace dying neurons in neurodegenerative diseases. Indeed, recent reports have provided evidence that, in some injury models, limited neuronal replacement occurs in the CNS. Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 28 (2005), S. 223-250 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Forty years since the initial discovery of neurogenesis in the postnatal rat hippocampus, investigators have now firmly established that active neurogenesis from neural progenitors continues throughout life in discrete regions of the central nervous systems (CNS) of all mammals, including humans. Significant progress has been made over the past few years in understanding the developmental process and regulation of adult neurogenesis, including proliferation, fate specification, neuronal maturation, targeting, and synaptic integration of the newborn neurons. The function of this evolutionarily conserved phenomenon, however, remains elusive in mammals. Adult neurogenesis represents a striking example of structural Plasticity in the mature CNS environment. Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult Plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 39 (1992), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The uppermost Permian Chuenmuping reef formed on the western side of a carbonate platform situated in the eastern Sichuan Basin, southern China. Contrasts exist between this western patch reef and the better known Jiantianba barrier reef complex on the eastern platform margin in western Hubei Province, 250 km to the east. Microbial micritic carbonates form significant components of the Chuenmuping reef limestones. Three types of fabric can be identified: irregular, clotted and scalloped-laminated. An additional, cuneiform fabric has been found only in fore-reef facies at Jiantianba.Irregular fabric is comparable with the surface of presently forming travertines at Rapolano Terme, central Italy, which are produced by calcification of cyanobacteria. Clotted fabric shows indistinct peloids which tend to lack rims, and are amalgamated into irregular masses, some of which exhibit bush-like arrangements where traces of filaments can be seen. Traces of filaments are observed in both dark and light layers in the scalloped-laminated fabric, again suggesting a microbial origin. Cuneiform fabric consists of peloids and filaments, and closely resembles deposits in Quaternary travertines which may have been caused by bacterial action.Chuenmuping reef shows a shallowing sequence in normal marine conditions. The micritic fabrics interpreted here as microbial occur more commonly in the upper part of the reef. This indicates that microbial micrites, with a cementing role, formed coevally with reef growth within the upper part of the photic zone.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 41 (1994), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Millimetre to centimetre sized arborescent shrub-like calcite precipitates are common constituents of hot water travertine shallow pool deposits of Quaternary age at Rapolano Terme, Tuscany, Italy. In the presently forming travertines, the shrubs consist of apparently random associations of (i) micrite aggregates and (ii) subhedral to euhedral rhombic spar crystal aggregates. In thin section, the micrite aggregates appear dark and the spar-rhomb aggregates light, giving the shrubs a mottled appearance.Travertines are basically produced by CaCO3 precipitation due to degassing and evaporation of the spring waters, although biological influence may also stimulate precipitation. The formation of masses of erect shrubs, rather than dense crystal crusts that form on slopes, is probably due to limited water flow in the pool environments.Microbes, including bacteria and diatoms, are important influences on shrub microfabric and external shape. The micrite aggregates are associated with bacteriform bodies, seen as tiny rods and spheres. The micrite precipitates around these bodies and in adjacent biofilm. Spar-rhomb precipitation appears to be external to the biofilm, and may be related to the presence of diatoms which are locally closely associated with the spar-rhombs, although an essentially inorganic origin, particularly for the more euhedral rhombs, cannot be ruled out.In the older Quaternary travertines, the original microfabric of the shrubs has been diagenetically altered. The original mottled appearance of the shrubs has become uniformly dark and micritic, and the evidence for the dual micritic and spar-rhomb origin of the shrubs is obscured or destroyed. Spar-micritization of the shrubs is probably due to abiotic, and locally biotic, dissolution. Previous studies did not recognize the diagenetic micritization and attributed shrub formation entirely to bacterial activity.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Sedimentology 46 (1999), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Holocene hot water travertine continues to form at Terme San Giovanni, near Rapolano Terme, central Italy, although artificial diversion of the water has reduced deposition. Mesothermal water (≈38–39 °C) emerging from fault-controlled vents located on a hilltop has created a linear fissure ridge 240 m long and up to 10 m high. Active parts of the ridge crest are covered by small cones; inactive parts are locally neotectonically fissured and have small pools. Ridge deposits include crystalline crust, paper-thin raft and shrub lithotypes. The ridge has both smooth and terraced marginal slopes, dominated by crystalline crusts with small shrubs in terrace pools. At the base of the ridge, there is a rapid transition to lateral flats and depressions, where water from the ridge collects and deposits shrub, irregular pisoid, reed, paper-thin raft and fine-grained and organic-rich travertines. Water channelled to nearby valley sides deposits thick crystalline crusts on valley slopes and waterfall overhangs, locally with small pools filled by smooth spherical pisoids. On the valley floor, mixing of waters forms varied stream-fill deposits that include micritic reed, paper-thin raft and coated bubble travertines. The diversity of travertine facies observed results from the location of the Terme San Giovanni hot springs on a hill crest, thus providing a wide array of downslope locations for further deposition. The abrupt facies transitions observed are characteristic of hot spring carbonates and result from a combination of rapid decrease in precipitation away from vents, variations in local surface topography and the feedback effect of travertine deposition itself, which dams and diverts water flow.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd, UK
    Sedimentology 45 (1998), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Late Pleistocene travertines up to 40 m thick near Rapolano Terme in Tuscany, central Italy, were precipitated by hot water issuing from springs on hillsides and flowing into adjacent depressions to mix with rainwater. Proximal light-coloured slope and terrace travertines pass distally into darker reed mound and depression-fill travertines. Lithotypes include crystalline crust, shrub, pisoid, paper-thin raft, coated bubble, reed, and lithoclast-breccia. High precipitation rates resulted in rapid slope aggradation and progradation. Dilution by rainwater likely lowered precipitation rates in depressions, but deposition was augmented by allochthonous material eroded from upslope travertines.Slope Depositional Systems consist of Smooth and Terrace Slope facies characterized by white crystalline crusts, with diverse additional lithotypes in terrace pools. Depression Depositional Systems have mixed light and dark travertines with horizontal to gently concave stratification. Extensive light-coloured Shrub Flat travertine is dominant; darker Marsh-Pool Facies composed of fine lithoclast and reed travertine is localized. Reed Mounds composed of mixed light and dark travertines localized by abundant reed growth, formed where spring water emerged near the bases of low angle slopes.Distal reduction in accretion rate was the major influence on sequence development. Light-coloured slope travertines interdigitate with darker depression deposits. Vertical aggradation of slope deposits, mound progradation, and filling of topographic depressions is expressed by advance and retreat of facies. Evolution from depression to slope or mound sequences is termed ‘steepening up’. Up-sequence change from slope or mound to depression facies is termed ‘levelling up’. Exposure surfaces associated with palaeosols are common in all facies and often constitute sequence boundaries. They are more closely spaced in depression sequences, reflecting slower and possibly also more discontinuous accumulation at sites furthest from hot springs.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 39 (1992), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Small (5–30 μm) aggregates of aragonite needles occur in calcite crystal crusts of present day hot water slope travertines at Rapolano Terme in Tuscany, Italy. The aggregates are mainly concentrated in irregular, wispy and dark laminae which cross-cut calcite crystal feathers to create a pervasive millimetre scale banded appearance in the deposit; they also occur less commonly scattered irregularly through the calcite layers. The aragonite needle aggregates are in the form of crosses, fascicles (sheaf shaped bundles, or dumbbell shaped), rosettes and spherulites. Locally, irregular masses of needles also occur. The fascicles, rosettes and spherulites have hollow centres which resemble microbial components (?fungal spores, bacterial colonies and pollen), suggesting that the aragonite crystals are biotically nucleated. The lamination is interpreted to reflect diurnal control. Stimulation of microbial activity during daylight concentrates cells in laminae and promotes aragonite calcification. Calcite feather crystals, although traversed by the aragonite aggregate laminae, have a clear appearance under the light microscope. They form more or less continuously through the diurnal cycle by abiotic precipitation. The constant association of aragonite with organic nuclei, irrespective of whether the latter are in laminae or scattered through the calcite layers, supports a biotic control on aragonite formation. Lamination in Pleistocene travertines is superficially similar to that in the present day deposits, but is diagenetically altered. In the Pleistocene deposits, the calcite feathers appear dark under the light microscope and the aragonite aggregates, where they are not altered to dark calcite, are dissolved, together with parts of the adjacent spar calcite, and therefore appear light coloured.
    Type of Medium: Electronic Resource
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