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‘Tubular’ epithelioid cell nevus: a new variant of Spitz's nevus (1998)

Burg, Guenter ; Kempf, Werner ; Höchli, Matthias ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of cutaneous pathology 25 (1998), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The term Spitz's nevus refers to a large spectrum of nevi composed of spindle and/or epithelioid cells. We report on a hitherto undescribed tubular variant of a dermal epithelioid nevus, characterized by aggregates composed exclusively of cuboidal cells with the prominent feature of tubular or microcystic structures, Immunohistochemically, the epithelioid cells expressed melanocytic markers (S-100, NKI/C3) lacking markers for cytokeratin or carcinoembryonic antigen. The three-dimensional analysis of the lesions by confocal laser scanning microscopy revealed the structural configuration of tubular or microcystic empty spaces bordered by cuboidal nevus cells. This rare variant of epithelioid nevus is another example for the remarkable diversity of Spitz's nevi.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0560.1998.tb01778.x

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Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation (1999)

Mueller, Andrea ; Bächi, Thomas ; Höchli, Matthias ; [et al.]

Springer

Histochemistry and cell biology 111 (1999), S. 453-459

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ISSN: 1432-119X

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract S100 proteins, a subgroup of the EF-hand Ca2+-binding protein family, regulate a variety of cellular processes via interaction with different target proteins. Several pathological disorders, including cancer, are linked to altered Ca2+ homeostasis and might involve the multifunctional S100 proteins, which are expressed in a cell- and tissue-specific manner. The present work demonstrates a distinct intracellular localization of S100A6, S100A4, and S100A2 in two tumor cell lines derived from metastatic epithelial breast adenocarcinoma (MDA-MB231) and cervical carcinoma (HeLa). Treatment of the cells by thapsigargin, the ionophore A23187, or cyclic ADP-ribose, to increase [Ca2+]i via different pathways, led to relocation of S100A6 and S100A4 but only partially of the nuclear S100A2, as demonstrated by confocal laser scanning microscopy. These findings support the hypothesis that S100 proteins could play a crucial role in the regulation of Ca2+ homeostasis in cancer cells.