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A prospective study of cancer incidence in a cohort examined for allergy (1995)

Eriksson, N. E. ; Holmén, A. ; Högstedt, B. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Allergy 50 (1995), S. 0

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ISSN: 1398-9995

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: In order to assess the association between atopy and cancer risk, a cohort of 6593 skin-prick-tested patients was established. Among atopic subjects, no overall increased cancer risk was found, but the incidence of both breast cancer (standardized incidence ratio (SIR) 2.50, 95% CI 1.01–5.16) and malignant lymphomas (SIR 4.40, 95% CI 1.20–11.3) was significantly enhanced. Atopic subjects with asthma showed a decreased overall cancer risk (SIR 0.73, 95%, CI 0.27–1.60), as compared with the other asthmatic subjects (SIR 1.46, 95% CI 1.03–2.04). The cancer risk for subjects with rhinitis was near unity (SIR 1.11), irrespective of whether the subjects were atopic or not. An almost significant risk increase for cancer was observed among subjects with urticaria (SIR 1.70, 95% CI 0.99–2.80). Our results support neither the original hypothesis of an overall cancer protective effect of atopy, nor that of an opposite effect; rather, they strengthen the view that the association between atopic diseases and cancer is complex.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1398-9995.1995.tb01212.x

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Increased frequency of micronuclei in lymphocytes of Swedish chimney sweeps (1994)

Holmén, A. ; Karlsson, A. ; Bratt, I. ; [et al.]

Springer

International archives of occupational and environmental health 66 (1994), S. 185-187

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ISSN: 1432-1246

Keywords: Micronucleus test ; Lymphocyte subsets ; Chimney sweeps ; Asbestos ; Benzo[a]pyrene

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Forty-five Swedish chimney sweeps and 49 controls were investigated with micronuclei stimulated by phytohemagglutinin and pokeweed mitogen and by analysis of lymphocyte subgroups and neutrophilic leukocytes. There was a statistically significant effect among sweeps with respect to both micronuclei variables and neutrophilic leukocytes. The effect on lymphocyte micronuclei was most prominent in pokeweed mitogen-stimulated cells, which may imply that the T4 lymphocytes were preferentially damaged by the occupational exposure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00380778

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Frequency of patients with acute asthma in relation to ozone, nitrogen dioxide, other pollutants of ambient air and meteorological observations (1997)

Holmén, A. ; Blomqvist, J. ; Frindberg, H. ; [et al.]

Springer

International archives of occupational and environmental health 69 (1997), S. 317-322

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ISSN: 1432-1246

Keywords: Key words Asthma-epidemiology ; Air-pollutants ; Environmental adverse effects ; Ozone adverse effects ; Nitrogen dioxide adverse effects

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Objective. To study the association of the daily frequency of registration of patients with acute asthma at the emergency department of a central hospital in the south-west of Sweden with levels of air pollution and meteorological observations. Methods. A retrospective longitudinal study was made of asthma patients taken from a hospital registry. This information was correlated with measurements of ozone, nitrogen dioxide, sulphur dioxide, toluene, temperature and relative humidity. Patients were from the catchment area of the Central Hospital of Halmstad containing around 120 000 inhabitants. A total of 4127 visits of patients with acute asthma to the emergency department at the Central Hospital of Halmstad were registered during a period of 1247 days from January 1990 to May 1993. The differential optical absorption spectroscopy (DOAS) technique was used to monitor levels of air pollutants over a distance of 1000 m in the central part of the town of Halmstad. Data on temperature, relative humidity, precipitation, wind speed and wind direction for the time period were supplied by the Swedish Meteorological and Hydrological Institute (SMHI). Results. There were many statistically significant correlations between the levels of air pollutants and the meteorological measurements and a strong negative correlation between ozone and nitrogen dioxide. There was a statistically significant effect on asthma visits in children of low temperature and high nitrogen dioxide levels, and on asthma visits in adults of high temperature and high levels of ozone. Conclusions. There was a different reaction pattern in children and adults with asthma regarding temperature and ozone/nitrogen dioxide. The strong correlations between temperature and air pollution and between the levels of ozone and nitrogen dioxide made the true relation between asthma, air pollution and temperature hard to evaluate statistically.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004200050154

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Comparison among five mutagenicity assays in workers producing polyurethane foams (1988)

Holmén, A. ; Åkesson, B. ; Hansén, L. ; [et al.]

Springer

International archives of occupational and environmental health 60 (1988), S. 175-179

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ISSN: 1432-1246

Keywords: Isocyanates ; Amines ; Occupational exposure ; Cytogenetic testing ; Mutagenic assays

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Thirty-two male individuals exposed to isocyanates and amines during the production of plastic foams and 20 male referents were studied by cytogenetic methods (chromosomal aberrations, sister chromatid exchanges and micronuclei in lymphocytes) and by urinary mutagenic assays (thioether concentrations and mutagenic activity with Salmonella TA98 and E. Coli WP2 uvrA). The occupational exposure was monitored by measurements of toluene diisocyanate and N-methylmorpholine in work-room air. The levels were below the current Swedish hygienic standards. Although all parameters, except the sister chromatid exchanges, showed increased mean values for the exposed group compared to the referents, only the urinary thioether concentrations differed significantly. The study was, however, non-conclusive with regard to a genetic effect of the occupational exposure as measured by the cytogenetic parameters. This may be due to the low exposure level. In the micronuclei frequencies there was a significant effect of age. Smoking significantly affected the SCE frequencies, the thioether concentrations and the mutagenic activities in the Salmonella assay. There were statistically significant correlations between the urine specimens collected during one working day and the following morning with regard to the mutagenic activities in the Salmonella and E. coli assays, and in the thioether concentrations as well. The association between the different cytogenetic and urinary mutagenic assays were weak but there were several statistically significant correlation coefficients, indicating that the variables may have a common metabolic background.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00378694

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