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The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity (2003)

Müller, Gerd ; Höpken, Uta E. ; Lipp, Martin

Oxford, UK : Munksgaard International Publishers

Immunological reviews 195 (2003), S. 0

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ISSN: 1600-065X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary: The development of secondary lymphoid organs is a complex process dependent on a coordinated interaction of cells of hematopoietic and non-hematopoietic origin. In this context, chemokines and cytokines belonging to the tumor necrosis factor (TNF)/lymphotoxin (LT) family are critical signaling molecules during the initial steps of lymph node and Peyer's patch organogenesis. Homeostatic chemokines, such as CXCL13, CCL21, and CCL19, as well as their corresponding receptors, CXCR5 and CCR7, have now been shown to closely cooperate in the development of lymphoid organs and the maintenance of lymphoid tissue microarchitecture. We summarize recent data on the function of CXCR5 and CCR7 and their intricate connection to the TNF/LT system in order to refine the current model of lymphoid organ development.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1034/j.1600-065X.2003.00073.x

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The C5a chemoattractant receptor mediates mucosal defence to infection (1996)

Höpken, Uta E. ; Lu, Bao ; Gerard, Norma P. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 383 (1996), S. 86-89

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] The murine C5a receptor (C5aR) gene4 was deleted through homologous recombination with the targeting vector shown in Fig. la. Correctly targeted Jl embryonic stem cells were used to generate chimaeric mice, several of which transmitted the targeted allele through the germ line (Fig. Ib). To confirm ...