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  • 1
    Electronic Resource
    Electronic Resource
    Activity-dependent regulation of alternative splicing patterns in the rat brain (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alternative splicing plays an important role in the expression of genetic information. Among the best understood alternative splicing factors are transformer and transformer-2, which regulate sexual differentiation in Drosophila. Like the Drosophila genes, the recently identified mammalian homologues are subject to alternative splicing. Using an antibody directed against the major human transformer-2 beta isoform, we show that it has a widespread expression in the rat brain. Pilocarpine-induced neuronal activity changes the alternative splicing pattern of the human transformer-2-beta gene in the brain. After neuronal stimulation, a variant bearing high similarity to a male-specific Drosophila tra-2179 isoform is switched off in the hippocampus and is detectable in the cortex. In addition, the ratio of another short RNA isoform (htra2-beta2) to htra2-beta1 is changed. Htra2-beta2 is not translated into protein, and probably helps to regulate the relative amounts of htra2-beta1 to beta3. We also observe activity-dependent changes in alternative splicing of the clathrin light chain B, c-src and NMDAR1 genes, indicating that the coordinated change of alternative splicing patterns might contribute to molecular plasticity in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00486.x
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  • 2
    Electronic Resource
    Electronic Resource
    Guidance of Thalamocortical Axons by Growth-promoting Molecules in Developing Rat Cerebral Cortex (1995)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 7 (1995), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Substrate-bound guidance cues play an important role during the development of thalamocortical projections. We used time-lapse video microscopy to study the growth behaviour of thalamic axons on different substrates. On embryonic cortical membranes and on a pure laminin substrate, thalamic fibres advanced relatively slowly (∼15 μm/h) and on average their growth cones retracted transiently every ∼5 h. In contrast, on membranes prepared from early postnatal cortex, thalamic fibres grew twice as fast and spontaneous growth cone collapse occurred ∼8 times less often. Experiments in which we used the sugar-binding lectin peanut agglutinin or heat inactivation to change the membrane properties indicated that these differences are due to growth-supporting molecules on postnatal cortical membranes. When offered a choice between embryonic and postnatal cortical membranes, thalamic axons preferred the postnatal membrane substrate. Time-lapse imaging revealed that borders between these two substrates effectively guided thalamic fibres, and in most cases axons changed their direction without collapse of the growth cone. Our results suggest that thalamic axons can be guided by the spatial distribution of growth-promoting molecules in the developing cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1995.tb00719.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Highly ordered arrangement of single neurons in orientation pinwheels (2006)
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 925-928 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the visual cortex of higher mammals, neurons are arranged across the cortical surface in an orderly map of preferred stimulus orientations. This map contains ‘orientation pinwheels’, structures that are arranged like the spokes of a wheel such that orientation changes ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05019
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  • 4
    Electronic Resource
    Electronic Resource
    Spatio–temporal frequency domains and their relation to cytochrome oxidase staining in cat visual cortex (1997)
    [s.l.] : Nature Publishing Group
    Nature 385 (1997), S. 529-533 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Previous studies have suggested that the primary visual cortex performs a two-dimensional Fourier-like analysis of the retinal image into its spatial frequency components1 4'12 I8. Single-unit recordings addressing the question of a clustering of cortical cells tuned to similar spatial scales came ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/385529a0
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    Paper (German National Licenses)
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