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  • 1
    Electronic Resource
    Electronic Resource
    IFN-β-Therapie bei der Haarzelleukämie (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 688-690 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 11 Patienten mit einer Haarzell-leukämie wurden zwei bis sechs Monate lang mit Beta-Inferferon (IFN-β; 3 × 4 Mio. I.E./Woche i.v.) behandelt. Von 8 auswertbaren Patienten erreichten 3 eine partielle Remission, 2 eine minor response, während 3 Patienten keine Verbesserung ihrer hämatologischen Werte zeigten. Als Nebenwirkungen traten die für die IFN-Therapie typischen grippeähnlichen Symptome bei 9 der 11 behandelten Patienten auf. Bei einem Patienten wurde ein Rückgang der Knochenmarksinfiltration unter IFN-β beobachtet. Diese Daten zeigen, daß IFN-β bei der Haarzelleukämie wirksam ist.
    Notes: Summary Eleven patients with histologically proven hairy-cell leukemia were treated for 2 to 6 months with a natural beta-interferon (β-IFN) preparation (3 × 4 million units week i.v.). Three of the eight evaluable patients experienced a partial response, two a minor response, and three no improvement. A reduction of the hairy-cell infiltration of the bone marrow was observed in one patient. Typical IFN side-effects with flu-like symptoms were noted. These results demonstrate that IFN-β has some clinical efficacy in hairy-cell leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875507
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of melphalan during intermittent therapy of multiple myeloma (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 187-193 
    Details
    ISSN: 1432-1041
    Keywords: melphalan ; myelomas ; pharmacokinetics ; intermittent therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary During intermittent melphalan-prednisone therapy the area under the plasma concentration-time curve of melphalan increased by an average of 45% after oral or intravenous administration of the drug in myeloma patients during the initial three courses at six-week intervals. The rise in melphalan plasma concentrations could not be referred to an alteration in melphalan elimination, metabolism, erythrocyte/plasma partition ratio, or protein binding. A possible explanation could be that covalent binding sites of melphalan were successively saturated during intermittent treatment, resulting in higher drug concentrations during successive courses of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609251
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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