Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Coenzyme A or adenosine inhibiting acetylcholine release? (reply) (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 722-722 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] COOK ET AL. REPLY--There is no doubt that some tissues possess the enzymes necessary to metabolise extracellular purine nucleotides to their equivalent nucleosides, so that there is the likelihood of adenosine being formed from any nucleotide which is based on the adenosine moiety. Although not ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274722a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Coenzyme A is a purine nucleotide modulator of acetylcholine output (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 768-771 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The effects of CoA and its analogues (acetyl-CoA, adenosine 3'5'-diphosphate (adenosine 3'5' diPOO) on the mechanical activity of electrically-stimulated guinea-pig ileum6 were compared with those of the nucleotides ATP, 3'5'-cyclic AMP, dibutyryl-3'5'-cyclic AMP (dbcAMP) and to noradrenaline, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271768a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Irradiation detection (1990)
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 202-203 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/344202b0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Initial in vitro characterisation of phosphonopyruvate hydrolase, a novel phosphate starvation-independent, carbon-phosphorus bond cleavage enzyme in Burkholderia cepacia Pal6 (2000)
    Springer
    Archives of microbiology 173 (2000), S. 35-41 
    Details
    ISSN: 1432-072X
    Keywords: Key words Phosphonopyruvate ; Hydrolase ; C-P bond ; Inducible ; Phosphonoalanine ; Organophosphonates ; Deregulated ; pho regulon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A novel, inducible carbon-phosphorus bond cleavage enzyme, phosphonopyruvate hydrolase, was detected in cell-free extracts of Burkholderia cepacia Pal6, an environmental isolate capable of mineralising l-phosphonoalanine as carbon, nitrogen and phosphorus source. The activity was induced only in the presence of phosphonoalanine, did not require phosphate starvation for induction and was uniquely specific for phosphonopyruvate, producing equimolar quantities of pyruvate and inorganic phosphate. The native enzyme had a molecular mass of some 232 kDa and showed activation by metal ions in the order Co2+ 〉 Ni2+ 〉 Mg2+ 〉 Zn2+ 〉 Fe2+ 〉 Cu2+. Temperature and pH optima in crude cell extracts were ¶50 °C and 7.5, respectively, and activity was inhibited by EDTA, phosphite, sulfite, mercaptoethanol and sodium azide. Phosphonopyruvate hydrolase is the third bacterial C-P bond cleavage enzyme reported to date that proceeds via a hydrolytic mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050005
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Urethane reduces contraction to 5-hydroxytryptamine (5-HT) and enhances the action of the 5-HT antagonist ketanserin on the rat thoracic aortic ring (1995)
    Springer
    Journal of neural transmission 101 (1995), S. 183-193 
    Details
    ISSN: 1435-1463
    Keywords: Anesthetics ; aorta ; calcium ; 5-hydroxytryptamine (5-HT) ; ketanserin ; noradrenaline (NA) ; potassium ; rat ; urethane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The general anesthetic urethane (ethyl carbamate) is widely used in electrophysiological in vivo experiments. However, its pharmacological effects are poorly understood. Here, the effects of urethane on in vitro contractile responses of the rat thoracic aortic ring preparation were investigated. Bath application of 5-HT produced a concentration-dependent contractile response (EC50=4.3 × 10−6M). Urethane (11.2 mM=1mg/ml) shifted the concentration — response curve (CRC) for 5-HT to the right (EC50=1.7 × 10−5M) and decreased the maximal contraction by 30.8%. The CRC for NA (EC50=7.2 × 10−9M) was also shifted to the right by urethane (EC50=1.4 × 10−8M), but the shift of the 5-HT-CRC was twice that of the NA-CRC (3.95 vs. 1.95). The CRC to KCl was shifted rightwards only slightly by urethane (ratio 1.27) and the maximal contraction to KCl was not affected. The CRC to replacement of CaCl2 (0.1 – 10 mM) to KCl-depolarized vessels in a Ca2+ -free Krebs solution was unaffected by urethane. Ketanserin (10−9M) antagonized the contraction to 5-HT, and a combination of ketanserin and urethane was markedly more effective than either drug alone, decreasing the maximal contraction by 58%. Antagonism of NA contraction by prazosin (5×10−8M) was not increased by addition of urethane. The urethane dose used here approximates blood and brain concentrations required to produce anesthetic effects in mammals. It is possible that reductions in 5-HT transmission and, to a lesser extent, in NA transmission, but not blockade of Ca2+ or K+ channels, may contribute to the anesthetic effect of urethane. In addition, the action of the selective 5-HT2 antagonist ketanserin is clearly altered by urethane. These findings are important to consider when urethane is used for in vivo neurophysiological investigations, particularly when 5-HT mechanisms are involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271555
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...