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  • 1
    Electronic Resource
    Electronic Resource
    Cytotoxic Response of Cultured Tumor Infiltrating Lymphocytes to Autologous Human Glioblastoma Cells (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27114.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas (1990)
    Springer
    Acta neurochirurgica 107 (1990), S. 82-87 
    Details
    ISSN: 0942-0940
    Keywords: Epidermal growth factor receptor gene ; EGFR ; viral erb-B oncogene ; malignant gliomas ; glioblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been demonstrated that the epidermal growth factor receptor (EGFR) gene, the normal human counterpart of the viral erb-B oncogene, is amplified and overexpressed in over 50% of human malignant gliomas (HMGs). In the present study, analysis of the immunohistological staining characteristics of 57 HMGs using an anti-EGFR monoclonal antibody (mab) showed positive staining in 65% of the tumours with large cellular and regional differences in staining pattern and intensity. Screening a smaller number of HMGs with molecular hybridization techniques revealed 10/21 glioblastomas (48%) amplified for the gene; of 11 glioblastomas studied by Northern blot hybridization, 7 tumours with gene amplification showed RNA overexpression, the remaining 4 without amplification did not. Regional differences in DNA levels were observed by Southern blot in 2 tumours; in one particular case, amplification and overexpression were found to be localized to one half of a single HMG, the other half showing neither EFGR gene amplification nor overexpression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405784
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  • 3
    Electronic Resource
    Electronic Resource
    Expression and release of interleukin-1 by human glioblastoma cells in vitro and in vivo (1993)
    Springer
    Acta neurochirurgica 121 (1993), S. 199-205 
    Details
    ISSN: 0942-0940
    Keywords: Brain ; glioblastoma ; interleukin-1 ; neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study demonstrates interleukin-1 (IL-1) production by human glioblastorna cells bothin vitro andin vivo. The presence of IL-1α and IL-1β transcripts was analyzed in 4 cell lines. IL-1α mRNA was expressed constitutively in one cell line whereas constitutive IL-1β mRNA could not be detected in any of the cell lines. IL-1α transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell Unes and IL-1β mRNA in 2 of 4 cell lines. Culture fluid from these cell lines was tested for the presence of IL-1 using a specific radioimmuno-assay for either IL-1α or IL-1β. In agreement with the results on RNA, one of 4 cell lines was found to constitutively produce IL-1α but not IL-1β. After treatment with PMA and LPS, IL-1α was detected in the culture fluid from two other lines and IL-1β in the medium from three lines. That the IL-1 produced by these cell lines was biologically active was confirmed in a two step thymocyte proliferation assay. IL-1 like activity was detected in all samples that were positive in the radio-immuno-assay. Finally, immunohistological analysis on fresh frozen tumour sections provided evidence for IL-1 production by glioblastoma cellsin vivo. Fourteen out of 28 glioblastomas were stained with an anti-IL-1α monoclonal antibody while none of them was stained with an anti-IL-1β antibody.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809276
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of cALLa/NEP on gliomas: A possible marker of malignancy (1992)
    Springer
    Acta neurochirurgica 114 (1992), S. 3-7 
    Details
    ISSN: 0942-0940
    Keywords: cALLa ; neutral endopeptidase ; gliomas ; immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary First described on pre-B leukemia cells, the common acute lymphoblastic leukemia antigen (cALLa) is also expressed on glioma cellsin vitro. Its identity to neutral endopeptidase (NEP) (E.C.3.24.11) was corroborated by our finding that cALLa positive glioma cells had NEP activity. To study cALLa/NEP distribution on glial tumours in vivo, we examined 76 brain tumour biopsies by immunostaining techniques on frozen tissue sections using anticALLa (FAH99) and anti-NEP (135 A 3) monoclonal antibodies. We found that 96% of grade 4 gliomas (25/26) expressed NEP. Whereas only 45% (4/9) of grade 3 or anaplastic astrocytomas did. In low grade gliomas, we found 2 positive tumours out of 21 tested (10%). Double immunostaining procedures revealed that NEP was co-expressed with GFAP. However no NEP could be detected on non-glial brain tumours nor on reactive astrocytes. These results suggest that cALLa/NEP expression could be linked to malignant progression of gliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401105
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