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  • 1
    Electronic Resource
    Electronic Resource
    ENZYMES OF PHOSPHOINOSITIDE METABOLISM DURING RAT BRAIN DEVELOPMENT (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The activities of four enzymes concerned with inositol lipid metabolism have been determined in homogenates of rat brains of different ages. The enzymes are CDP-diglyceride inositol phosphatidate transferase, phosphatidylinositol kinase, diphosphoinositide kinase and triphosphoinositide phosphomonoesterase. The activities of all the enzymes increased with age. Phosphatidylinositol kinase activity rose most sharply well before myelination, reaching a maximum at about 6 days of age. Diphosphoinositide kinase and triphosphoinositide phosphomonoesterase activities increased most rapidly during myelination. The increase in CDP-diglyceride inositol phosphatidate transferase showed no definite association with any period of development. It is concluded that triphosphoinositide metabolism is associated with myelin or a closely related structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb06200.x
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  • 2
    Electronic Resource
    Electronic Resource
    SUBCELLULAR DISTRIBUTION OF ENZYMES OF GLUTAMATE METABOLISM IN RAT BRAIN (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 13 (1966), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1966.tb10285.x
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  • 3
    Electronic Resource
    Electronic Resource
    METABOLISM OF THE PHOSPHOINOSITIDES IN GUINEA-PIG BRAIN SYNAPTOSOMES (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The subcellular distribution of a number of enzymes concerned with inositol lipid metabolism has been studied in sub-fractions of disrupted guinea-pig brain synaptosomes. The enzymes were CDP-diglyceride: inositol phosphatidate transferase, phospha-tidylinositol kinase, diphosphoinositide kinase, diphosphoinositide phosphomonoesterase and diphosphoinositide diesterase. The distribution of phosphatidylinositol kinase in sub-fractions from water-treated synaptosomes was compared with that of other plasma membrane enzymes. After partial solubilization of synaptosomes by Triton X-100 the activities of phosphatidylinositol kinase and several other enzymes were examined.Distribution of phosphatidylinositol kinase closely resembled that of acetylcholinesterase in sub-fractions of synaptosomes. Both enzymes appeared to be localised in the outer membrane of the synaptosome. CDP-diglyceride: inositol phosphatidate transferase was present in all types of synaptosomal membrane. All three enzymes concerned with diphosphoinositide metabolism were found in the cytoplasm of the synaptosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05989.x
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  • 4
    Electronic Resource
    Electronic Resource
    Fatty Acid Metabolism (1988)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Plant Physiology and Plant Molecular Biology 39 (1988), S. 101-138 
    Details
    ISSN: 1040-2519
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pp.39.060188.000533
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  • 5
    Electronic Resource
    Electronic Resource
    Graminicide resistance in a blackgrass (Alopecurus myosuroides) population correlates with insensitivity of acetyl-CoA carboxylase (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 27 (2004), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The appearance of biotypes of the annual grass weed black-grass (Alopecurus myosuroides L. Huds), which are resistant to certain graminicides, is the most significant example of acquired resistance to herbicides seen so far in European agriculture. An investigation was perfomed into the basis of the specific cross-resistance to cyclohexanedione (CHD) and aryloxyphenoxypropionoic acid (AOPP) herbicides in the ‘Notts A1’ population of A. myosuroides, which survived treatment of fields with recommended rates of AOPP herbicides. In comparison with the wild-type ‘Rothamsted’ population, the resistant biotype showed over 100-fold resistance to these herbicides in a hydroponic growth system. Biosynthesis of fatty acids and activity of crude extracts of acetyl-CoA carboxylase (ACCase) were commensurately less sensitive to these herbicides in Notts A1 compared with the Rothamsted biotype. These data are consistent with the hypothesis that the highly resistant population has arisen through selection of a mutant ACCase which is much less sensitive to the AOPP and CHD graminicides. Rapidly growing cell suspension cultures established from the Notts A1 population also showed high resistance indices for CHD or AOPP herbicides compared with cultures from the Rothamsted biotype. Fatty acid biosynthesis and ACCase activity in the cell suspensions were similarly sensitive towards the graminicides to those in the foliar tissue counterparts of the resistant and sensitive populations. Moreover, purification of the main (chloroplast) isoform of acetyl-CoA carboxylase showed that this enzyme from the Notts A1 population was over 200-fold less sensitive towards the AOPP herbicide, quizalofop, than the equivalent isoform from the Rothamsted population. These data again fully supported the proposal that resistance in the Notts biotype is due to an insensitive acetyl-CoA carboxylase isoform. Overall, cell suspensions were also demonstrated to be excellent tools for further investigation of the molecular basis of the high level herbicide resistance which is prone to occur in A. myosuroides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0016-8025.2003.01118.x
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  • 6
    Electronic Resource
    Electronic Resource
    The effects of elevated atmospheric CO2 on lipid metabolism in leaves from mature wheat (Triticum aestivum cv. Hereward) plants (1998)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 21 (1998), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Winter wheat (Triticum aestivum L. cv. Hereward) plants were grown for 35 d either at 350 μmol mol–1 CO2 or at 650 μmol mol–1 CO2. Lipid synthesis was studied in these plants by incubating the 5th leaf on the main stem with [1–14C]acetate. Increased CO2 concentrations did not significantly affect the total incorporation of radiolabel into lipids of whole leaf tissue, but altered the distribution for individual lipid classes. Most noticeable amongst acyl lipids was the reduction in labelling of diacylglycerol and a corresponding increase in the proportion of phosphatidylcholine labelling. In the basal regions, there were similar changes and, in addition, phosphatidylglycerol labelling was particularly increased following growth in an enriched CO2 atmosphere. The stimulation of labelling of the mitochondrial-specific lipid, diphosphatidylglycerol, prompted an examination of the mitochondrial population in wheat plants. Mitochondria were localized in intact wheat sections by immunolabelling for the mitochondrial-specific chaperonin probe. Growth in elevated CO2 doubled the number of mitochondria compared to growth in ambient CO2. Fatty acid labelling was also significantly influenced following growth at elevated CO2 concentrations. Most noticeable were the changes in 16C:18C ratios for the membrane lipids, phosphatidylcholine, phosphatidylglycerol and monogalactosyldiacylglycerol. These data imply a change in the apportioning of newly synthesized fatty acids between the ‘eukaryotic’ and ‘prokaryotic’ pathways of metabolism under elevated CO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3040.1998.00332.x
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of elevated temperature and atmospheric carbon dioxide concentration on the quality of grain lipids in wheat (Triticum aestivum L.) grown at two levels of nitrogen application (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 18 (1995), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Wheat plants were cultivated under growth regimes combining two temperatures (ambient and 4°C above ambient temperature) with two concentrations or carbon dioxide (350 and 700 μmol mol) and two nitrogen fertilizer applications (high and low). The aim of this study was to define any changes in the acyl lipid composition of wheat grains which could result from alterations in the growth conditions. Qualitative and quantitative changes were observed in both non-starch and starch lipid fractions. Temperature was by far the most influential growth factor, although interactions between all three growth conditions occurred, as confirmed by analysis of variance. Growth at elevated temperatures had the general effect of reducing the amounts of accumulated lipids, particularly non-polar lipids (1322 nig fatty acids per 100 g fresh weight at ambient temperatures as opposed to 777 mg fatty acids per lOOg fresh weight at 4°C above ambient temperatures). There were changes in the proportions of the major non-starch as well as the starch lipids. In the former category, non-polar lipids (principally triacylglyc-erols), the membrane glycosylglyccridcs and phos-phatidylcholinc were the main constituents, whereas in the starch lipids, lysophosphatidylcholine and lysophos-phatidylethanolamine represented over 70% of the total. Depending on the growth conditions, the percentages of lipids such as monogalactosyldiacylglycerol, digalactosyl-diacylglycerol and phosphatidyleholine (non-starch) or the starch lysophosphatidylethanolamine varied 2-fold or more. Significant changes in the acyl composition of individual lipids were also observed, most often in the proportions of palmitate, oleate and linoleate. The observed alterations in wheat lipids arc likely to affect the properties of any flours derived from grain grown under climate change conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1995.tb00610.x
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  • 8
    Electronic Resource
    Electronic Resource
    Communication media use in the grandparent-grandchild relationship (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of communication 50 (2000), S. 0 
    Details
    ISSN: 1460-2466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: This study surveyed college-aged grandchildren as to the frequency of their communication with a grandparent using various media. Face-to-face (FtF) and telephone communication were used more frequently than written media, but all were used fairly frequently. Communication using all media was more frequent when the grandparent or grandchild initiated interaction as opposed to the parent. Relationships in which the grandparent initiated contact featured more use of written media (letters, e-mail, cards). Frequency of communication using all media was positively associated with relational quality. Telephone communication best predicted relational quality when use of other media was controlled. In this paper, I discuss implications for media richness theory, the communication predicament of aging model, and future research on grandparent-grandchild relationships.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2466.2000.tb02863.x
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  • 9
    Electronic Resource
    Electronic Resource
    Affiliation, pride, exchange, and distance in grandparents' accounts of relationships with their college-aged grandchildren (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of communication 50 (2000), S. 0 
    Details
    ISSN: 1460-2466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism
    Notes: This paper examines grandparents' written accounts of conversations with their college-aged grandchildren. Using a thematic analysis, we describe 4 themes that indicate the place of the relationship in the grandparents' lives and their general orientation to their grandchildren. It is argued that expressions of affiliation, pride, exchange (primarily of advice and information), and feeling distance from their grandchildren are fundamental elements of the relationship from the grandparents' perspectives. These are discussed in terms of the grandchild's place in the grandparent's life and the complexities of negotiating this relationship during a period of grandchild transition away from the parental home.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2466.2000.tb02851.x
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular analysis of the virulence locus of the Salmonella dublin plasmid pSDL2 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 5 (1991), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The virulence properties of various non-typhoid Salmonella serotypes depend on the presence of large plasmids 60–100 kb in size. We have shown previously that the virulence region on the 80 kb plasmid pSDL2 of Salmonella dublinLane maps within a 14kb SalI fragment. In this report we show that an 8.2kb region within this fragment is sufficient to express lethal disease in BALB/c mice. Sequence analysis of this segment revealed six sequential open reading frames designated vsdA–F, which encode putative proteins of 13–65kDa. Deletion analysis and location of Tn5-oriT inserts which abolish virulence suggest that vsdA, vsdC, vsdD and vsdE are essential for virulence expression. Downstream of vsdF we discovered a locus involved in stable plasmid maintenance. Deletion of that region resulted in plasmid multimerization and instability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1991.tb02111.x
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