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  • 1
    Electronic Resource
    Electronic Resource
    Hip fracture in elderly Japanese women; a review (1991)
    Springer
    Journal of bone and mineral metabolism 9 (1991), S. 33-34 
    Details
    ISSN: 1435-5604
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02375930
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  • 2
    Electronic Resource
    Electronic Resource
    Epidemiology of osteoporotic limb fractures in tottori prefecture, Japan (1991)
    Springer
    Journal of bone and mineral metabolism 9 (1991), S. 25-28 
    Details
    ISSN: 1435-5604
    Keywords: Epidemiology ; Hip fractures ; Distal radius fractures ; Proximal humerus fractures ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We review the results of our investigation of the incidence of fractures of the proximal femur, distal radius, and proximal humerus, in Tottori Prefecture, Japan, and compared our results with those found previously in other countries. During the period from 1986 to 1988, 918 proximal femoral, 1103 distal radial, and 260 proximal humeral fractures in patients over 35 years of age were recorded in Tottori Prefecture. In all fracture types, age-and sex-specific incidence was lower among Japanese than among European or North American whites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02375928
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  • 3
    Electronic Resource
    Electronic Resource
    Anomalies of ossification in the posterolateral femoral condyle: assessment by MRI (1999)
    Springer
    Pediatric radiology 29 (1999), S. 781-784 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Anomalies of ossification in the lower femoral epiphysis are often radiographically indistinguishable from juvenile osteochondritis dissecans. Objective. To clarify the MRI characteristics of the anomalies of ossification in the posterolateral femoral condyle that distinguish it from juvenile osteochondritis dissecans. Materials and methods. We retrospectively examined the medical records, plain radiographs (n = 4), MRI (n = 4) and follow-up MRI (n = 2) of four boys (age 8–11 years) with anomalies of ossification in the posterolateral femoral condyle. Results. Plain radiography showed symmetrical marginal irregularity of the posterolateral femoral condyles of both knees. These lesions were asymptomatic, and the areas of irregular radiographic appearances reduced in size or disappeared without treatment within a mean observation period of 3.5 months. MRI showed a clearly demarcated low-intensity islet with the same signal intensity as subchondral bone (which was considered to be an accessory ossification nucleus) in a high-signal area in which the signal intensity was equal to that of normal articular cartilage. The areas observed as radiolucent zones on plain radiography were visualised at the same signal intensity as articular cartilage, and were continuous with articular cartilage on MRI; thus they were regarded as uncalcified cartilage. These MR findings are different from MR images of osteochondritis dissecans. Conclusions. MRI is considered to be the most effective non-invasive diagnostic method for these two conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470050694
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  • 4
    Electronic Resource
    Electronic Resource
    Computed tomography in patients with Ehlers-Danlos syndrome (1985)
    Springer
    Neuroradiology 27 (1985), S. 443-445 
    Details
    ISSN: 1432-1920
    Keywords: CT ; Ehlers-Danlos syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three patients with Ehlers-Danlos syndrome were reported. Unusual findings on computed tomography were seen in two of the three patients. One case showed peculiar and marked dilatation of the 4th ventricle, supracerebellar cistern and lateral ventricle. The other case presented disproportionate enlargement of the anterior horn of the lateral ventricle. These CT findings in the two patients suggest that developmental abnormalities may constitute a structural defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327612
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  • 5
    Electronic Resource
    Electronic Resource
    Measurement of vertebral body dimensions of the thoracic and lumbar spines of 242 healthy women (1998)
    Springer
    Journal of bone and mineral metabolism 16 (1998), S. 27-33 
    Details
    ISSN: 1435-5604
    Keywords: Key words: diagnosis of osteoporosis ; roentgenography of spines ; dimension of vertebral body
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: To establish diagnostic criteria for osteoporosis using roentgenograms of vertebral bodies, the posterior margin, anterior margin, and central portion heights of 14 vertebral bodies in 242 healthy women were measured. It was demonstrated that the measurement of vertebral heights using a digitizer by one expert could be made with high accuracy, based on the results of comparison between roentgenograms on a 50% reduced scale and ordinary-scale roentgenograms as well as those of daily and day-to-day variations of the measured values. According to these measurements, the seventh thoracic vertebra showed the most marked tendency toward wedge formation and the fifth lumbar vertebra toward reverse-wedge formation. In the measurement of vertebral body heights, the accuracy decreased at vertebral levels where the images of thoracic vertebral bodies are superimposed upon by the shadows of cardiovascular organs. Because the variations in measurement values in Japanese were not significant in comparison with those in European and American persons, means minus 3 SD were almost the same as means minus 25% designated in Japan with respect to the ratio of anterior to posterior margin heights of vertebral bodies. Moreover, the means minus 3 SD were almost equal to means minus 20%, with respect to the ratio of central to posterior margin heights of vertebral bodies. Thus, our conclusion is that the definition of vertebral deformity as designated in Japan is sufficiently accurate for the diagnosis of osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050025
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  • 6
    Electronic Resource
    Electronic Resource
    Increasing incidence of distal radius fractures in Japanese children and adolescents (2000)
    Springer
    Journal of orthopaedic science 5 (2000), S. 356-360 
    Details
    ISSN: 1436-2023
    Keywords: Key words Distal radius fractures ; Children and adoles-cents ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate recent trends in the incidence of fractures in children and adolescents, we conducted a survey of distal radius fractures in 1992 and 1995 in Tottori Prefecture, Japan. Seven-hundred and forty-five patients under age 20 years were registered (562 males and 183 females). The age and sex-specific incidences of fractures in patients under 20 years of age were higher in males than in females, showing peaks at age 12–13 years for males and at age 10–11 years for females. The incidences had an obvious monthly variation, with peaks in spring and autumn. The age and sex-specific incidences were compared with those in the period 1986–1988, which we reported previously. The incidence in each year showed a significant increase with time for males but not for females. We conclude that the incidence of distal radius fractures in children and adolescents has a prominent peak matched by the age of the growth spurt, and the incidence of the fracture has increased in males during the past decade in Tottori Prefecture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760070043
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  • 7
    Electronic Resource
    Electronic Resource
    Incidence and risk factors of hip fractures in Japanese elderly women (1991)
    Springer
    Journal of bone and mineral metabolism 9 (1991), S. 14-16 
    Details
    ISSN: 1435-5604
    Keywords: Epidemiology ; Osteoporosis ; Hip Fractures ; Distal Radius Fractures ; Proximal Humeral Fractures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A fracture survey on osteoporotics was performed in Tottori Prefecture during the period from 1986 to 1988. The incidence of fractures of the hip, distal radius, and proximal humerus was lower among Japanese than among European or North American whites by comparing our results with those reported previously in other countries. A retrospective case control study was performed in patients with and without hip fractures, and we concluded that hip fractures have been related to various lifestyle variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02377979
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  • 8
    Electronic Resource
    Electronic Resource
    The change of bone mineral density in secondary osteoporosis and vertebral fracture incidence (1999)
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 119-124 
    Details
    ISSN: 1435-5604
    Keywords: Key words: secondary osteoporosis ; bone mineral density ; vertebral fracture incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Causes of secondary osteoporosis are diverse, and bone changes in this condition have been elucidated less than those in primary osteoporosis. In this study, bone mineral density (BMD) was measured in the lumbar spine, distal and proximal sites of the radius, and calcaneus in representative disorders that cause secondary osteoporosis to evaluate its changes. Also, the incidence of nontraumatic vertebral fracture was examined. The subjects were 80 patients with rheumatoid arthritis, 50 patients undergoing glucocorticoid (steroid) therapy, 20 patients with chronic hepatitis, 24 patients with liver cirrhosis, 14 patients with primary biliary cirrhosis (PBC), 26 patients with diabetes mellitus, and 20 postgastrectomy patients; all were ambulatory female outpatients. Two hundred females with primary osteoporosis were examined as a control group. The reproducibility of the measurement of the BMD was satisfactory at about 3% by all methods of measurement employed. Concerning changes in BMD, periarticular trabecular bone density was most markedly reduced in the rheumatoid arthritis group. The patients receiving steroid therapy showed the greatest decreases in the trabecular bone mineral density at the distal 4% of the radius and lumbar spinal BMD. In addition, the threshold of vertebral fracture was higher in those undergoing steroid therapy than in those with primary osteoporosis. The patients with PBC showed the greatest decreases in BMD among patients with chronic liver disorders, and no decrease in BMD was noted in the chronic hepatitis group. BMD was reduced only in the radius in the patients with diabetic mellitus, and it was generally reduced in the postgastrectomy patients. BMD of the calcaneus was not reduced in any group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050074
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  • 9
    Electronic Resource
    Electronic Resource
    Higher culture pH is preferable for inclusion body formation of recombinant salmon growth hormone inEsherichia coli (1991)
    Springer
    Biotechnology letters 13 (1991), S. 385-388 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Higher culture pH of 7.6 was shown to be preferable for the inclusion body formation of salmon growth hormone (SGH) inEscherichia coli harboring a recombinant plasmid. High-level formation of SGH inclusion bodies was achieved at 33°C (pH 7.6). Growth inhibition by soluble SGH was also observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01030987
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  • 10
    Electronic Resource
    Electronic Resource
    L-Lysine production by mutants of Bacillus licheniformis (1981)
    Springer
    Biotechnology letters 3 (1981), S. 425-430 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A bacterium able to grow at 46°C was isolated from soil and identified asBacillus licheniformis. L-Lysine producing mutants were derived from the bacterium by the introduction of resistance to S-(2-amino)-ethylcysteine (thialysine) and auxotrophy.One of the mutants, HBR-2 (Thialysiner, Leu−, Homoserine−), produced L-lysine at a concentration of 30 mg/ml in a molasses medium containing 10% reducing sugar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01134102
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