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  • 1
    Electronic Resource
    Electronic Resource
    Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 39 (2003), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The site stripping for clock detection procedure was implemented in the recently developed maximum likelihood framework for estimating evolutionary rates and divergence times in measurably evolving populations. The method was used to investigate the effect of rate variability on estimating divergence times in non-clock-like trees for human immunodeficiency viruses and hepatitis C viruses. We validate our approach by comparing dated coalescent nodes in molecular phylogenies with known dates of transmission. Our method was able to rapidly recover clock-like behavior and to indicate the presence and direction of a bias when estimates of divergence times using the unstripped data were flawed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0928-8244(03)00239-6
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  • 2
    Electronic Resource
    Electronic Resource
    Letter to the editor (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 995-995 
    Details
    ISSN: 1530-0358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02139117
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inherited Hypertension in Rats (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 727-728 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have developed several families with a high incidence of hypertension by selective cross-breeding, and in three strains (A, B and C) by intensive inbreeding, using brother-sister mating. Selective cross-breeding has produced higher pressures than inbreeding (Fig. 1). Comparison of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/182727a0
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of vagotomy on gastric emptying (1970)
    Springer
    Digestive diseases and sciences 15 (1970), S. 1047-1052 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine whether pyloroplasty or a disrupted osmoreceptor mechanism is primarily responsible for the increased gastric emptying of hypertonic sugar solutions after vagotomy and pyloroplasty, test meals of 10% glucose (556 mOsm/kg) and NaCl (200 mOsm/kg) were administered to duodenal ulcer patients with no prior operation, after vagotomy and pyloroplasty, and in patients with prior vagotomy, hiatal herniorrhaphy, and no pyloroplasty. Hypertonic glucose meals were emptied more rapidly than normal after both operations. The hypotonic NaCl meal was emptied no faster postoperatively than it was preoperatively. The results rule out pyloroplasty as the primary factor responsible for the observed increased rate of gastric emptying. Instead, the data suggest that the osmoreceptor mechanism described by Hunt is disrupted by vagotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02232865
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  • 5
    Electronic Resource
    Electronic Resource
    Tritiated digoxin XVI (1971)
    Springer
    Digestive diseases and sciences 16 (1971), S. 903-908 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sites and mechanisms of digoxin absorption in man are unknown. We have studied the fate of digoxin in the stomach by adding3H digoxin to an aqueous meal of 10% glucose and phenol red. The human stomach absorbed3H digoxin which was not changed by gastric digestion. This process appeared to contribute to the entry of tritium radioactivity into the serum within 5 minutes after intragastric administration. Gastric absorption was reduced in the presence of gastritis or gastric ulcer. Although 9 of 13 patients exhibited gastric absorption of3H digoxin, the stomach did not appear to be a major site of absorption in these studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238171
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  • 6
    Electronic Resource
    Electronic Resource
    The parietal cell mass: Growth hormone relationship in man (1971)
    Springer
    Digestive diseases and sciences 16 (1971), S. 139-143 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The maximal histamine response in 3 untreated patients with acromegaly was significantly elevated. To determine whether chronic subclinical elevations of growth hormone might be responsible for the enlarged parietal cell mass in patients with duodenal ulcer, control mechanisms of growth hormone in these patients were challenged with arginine and glucose. No abnormalities of growth hormone control were found. There was no apparent relation between the growth hormone response to arginine and the maximal histamine response in patients with duodenal ulcer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02284450
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  • 7
    Electronic Resource
    Electronic Resource
    Gastric acid secretory differences in patients with Heineke-Mikulicz and Finney pyloroplasties (1975)
    Springer
    Digestive diseases and sciences 20 (1975), S. 947-950 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study gastric emptying and secretion, liquid meals of 10% glucose lasting 15 and 30 min, and physiological saline meals lasting 30 min, all containing phenol red as a gastric nonabsorbable marker, were given to postvagotomy patients with Finney or Heineke-Mikulicz pyloroplasties. No differences in emptying were found. A small but statistically greater amount of acid was found in the stomach with the 15-min glucose meal after Heineke-Mikulicz pyloroplasty. This represented greater acid secretion into glucose meals generally after Heineke-Mikulicz pyloroplasties, because of the larger volume contained in the stomach at 15 min. 15-min glucose meal acid secretion correlated with basal acid concentration but not with insulin-stimulated gastric acid output. The small excess of acid in the Heineke-Mikulicz group's 15-min glucose meals may represent a small, maintained excess of gastric acid in this group detected only in the brief glucose meals due to rapid and erratic gastric emptying of liquids after vagotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01070881
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  • 8
    Electronic Resource
    Electronic Resource
    Vagal control of histamine-stimulated gastric acid secretion (1973)
    Springer
    Digestive diseases and sciences 18 (1973), S. 801-802 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01070851
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Postvagotomy insulin infusion test (1975)
    Springer
    Digestive diseases and sciences 20 (1975), S. 599-601 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01074946
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibition of gastric acid secretion by blood drawing from an indwelling venous needle (1976)
    Springer
    Digestive diseases and sciences 21 (1976), S. 677-679 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate a possible inhibitory effect of blood drawing through an indwelling forearm vein needle on gastric acid secretion, 11 subjects were studied on four occasions each. The first session was for adapting the subject to the 3-hr collection of gastric juice. In 7 subjects the second through fourth sessions gave three conditions in balanced order: (1) an indwelling forearm vein needle and the withdrawal of 5 or 10 cc of blood every 20 min, (2) only a nonfunctional “dummy” needle implanted subcutaneously in the forearm skin, and (3) the control condition with no needle. In four additional subjects the sessions were identical except that condition (1) involved an indwelling forearm vein needle kept open by a slow infusion of saline solution and no blood was drawn. Phenol red recovery from an initial intragastric injection was measured in all. Results showed that blood drawing, but not saline infusion or venipuncture per se, inhibited gastric acid output.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01071966
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