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  • 1
    Electronic Resource
    Electronic Resource
    symposium i-1. pathophysiology and treatment of pressure ulcer
Moderated by Koicki Hirata: The Study of Clinical Usefulness of Basic FGF (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recently, basic FGF (fibroblast growth factor) has been made clinical use for wound cure. We studied clinical usefulness of basic FGF.Cases:  Nine cases took wound necrosis by infection. Two cases took burn after mastectomy. One case took abscess in pelvic space.Methods:  We investigated healing rate of wound by healing area per day. And we evaluated histological wound healing by HE staining, labeling index of Ki64 staining, CD34 staining for index of neovascularization, and α-smooth muscle actin staining for differentiation of fibroblasts.Result:  Healing rate of nine cases with wound necrosis by infection was 5 cm2/day and that of two cases with burn after mastectomy was 0.5 cm2/day. Labeling index was more than 10%. CD34 staining showed increasing neovascularization of healing tissues with treatment of bFGF, compaired with that recieved other treatments. But the case with abscess did not recover and took the reoperation for treatment.Conclusion:  We concluded that bFGF was efficacious against tissue damage and useful for wound cure. But basic FGF was not useful for the infectious focus without control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116z.x
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  • 2
    Electronic Resource
    Electronic Resource
    Hepatocellular carcinoma coexistent with adenomatous hyperplasia: Report of a case (1993)
    Springer
    Surgery today 23 (1993), S. 528-531 
    Details
    ISSN: 1436-2813
    Keywords: adenomatous hyperplasia ; multicentric development ; hepatocellular carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We would like to draw attention to hepatic tumor-like lesions which frequently complicate the differential diagnosis of hepatocellular carcinoma (HCC), while considering their pathology and diagnosis by radiographic imaging. In particular, adenomatous hyperplasia is recognized as a precancerous lesion of HCC, and the relationship between adenomatous hyperplasia and the multicentric development of HCC is recognized. We observed a patient who demonstrated hyperplastic changes in both the liver cells and a well-differentiated HCC lesion adjacent to the adenomatous hyperplasia, suggesting a multicentric development of the HCC. The histopathological features of adenomatous hyperplasia are also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00730629
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  • 3
    Electronic Resource
    Electronic Resource
    High serum alpha-fetoprotein concentration associated with pseudoinfarction of a cirrhotic liver: Report of a case (1996)
    Springer
    Surgery today 26 (1996), S. 818-821 
    Details
    ISSN: 1436-2813
    Keywords: alpha-fetoprotein (AFP) ; pseudoinfarction ; hepatocellular carcinoma (HCC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 65-year-old man with cirrhosis of the liver in whom a portal vein thrombus was found to be the cause of a marked elevation in serum alpha-fetoprotein (AFP). The patient presented with fever and abdominal pain, and a diagnostic work-up revealed a liver mass and an increased serum AFP concentration of 91000 ng/ml. The mass gradually regressed, and the AFP concentration simultaneously decreased to 163 ng/ml. However, because hepatocellular carcinoma (HCC) could not be ruled out, a partial hepatectomy was performed. Histological examination of the resected specimen revealed a thrombus of the portal vein surrounded by the fibrosis associated with liver cirrhosis, but no neoplastic lesion was found. Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311644
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment for Accidental Occlusion of the Hepatic Artery After Hepatic Resection: Report of Two Cases (1999)
    Springer
    Surgery today 29 (1999), S. 268-272 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: hepatic artery occlusion ; hepatic resection ; hepatocyte growth factor ; hepatic vein oxygen saturation ; arterialization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050402
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  • 5
    Electronic Resource
    Electronic Resource
    A correlation between arterial ketone body ratio and concentration of β-hydroxybutyrate as an indicator of hepatic functional reserve (1992)
    Springer
    Surgery today 22 (1992), S. 244-247 
    Details
    ISSN: 1436-2813
    Keywords: ketone body ratio ; mitochondrial function ; hepatic functional reserve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the correlation between the arterial blood ketone body ratio (AKBR) and β-hydroxybutyric acid (HBAC) in the course of a 75 g glucose tolerance test. The correlation was revealed to be represented by an equation of Y=A+BX [X=log(HBAC), Y=log(AKBR)] with high significance. This expression existed in both normal individuals and patients with liver, biliary tract or pancreas disease. The postoperative course was unsatisfactory because of liver dysfunction in cases whose value B was more than −0.6 in bisegmentectomy and more than −0.45 in uni- or subsegmentectomy. The coefficient B in the equation was suggested to contribute to the evaluation of hepatic functional reserve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308829
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  • 6
    Electronic Resource
    Electronic Resource
    Exogenous hepatocyte growth factor markedly stimulates liver regeneration following portal branch ligation in dogs (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. 233-237 
    Details
    ISSN: 1432-0843
    Keywords: Key words HGF ; Liver regeneration ; Portal branch ligation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Portal branch ligation (PBL) or embolization prior to extensive hepatectomy has been employed to increase the functional reserve of the remaining liver. This study investigated the effects of human recombinant hepatocyte growth factor (rh-HGF) on liver regeneration following PBL in dogs. Beagle dogs were subjected to PBL and were divided into two groups, a control group (n=11) without rh-HGF and a treated group (n=12) receiving postoperative rh-HGF at 250 ng/kg via the portal vein. Dogs were killed 72 h or 14 days following PBL. We studied the changes in serum HGF level, DNA synthesis of the liver, hepatocyte size, liver weight, and liver function tests. In the HGF group, the ratio of whole liver weight to body weight increased significantly, and both ligated and nonligated lobes showed marked increases in weight. The nonligated lobes in the HGF group showed significant increases in both DNA synthesis and hepatocyte size. Moreover, ligated lobes in the HGF group showed an increase in DNA synthesis without hypertrophy compared with the control group. Administration of rh-HGF did not significantly affect liver function tests. Ligation of the portal branch supplying the portion of liver to be resected, coupled with the administration of rh-HGF, is a useful strategy to increase hepatic reserve in advance of major hepatectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050476
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of HGF and TGF-β1 mRNA after partial hepatectomy in rats with liver cirrhosis (1995)
    Springer
    Surgery today 25 (1995), S. 237-243 
    Details
    ISSN: 1436-2813
    Keywords: experimental cirrhotic liver ; partial hepatectomy ; HGF ; TGF-β1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatocyte growth factor (HGF) is a potent mitogen for the maturation of hepatocytes in vitro which plays a role in liver regeneration in vivo. In addition, transforming growth factor-β1 (TGF-β1) is also a potent regulator of liver regeneration. In attempting to clarify the mechanisms related to liver regeneration after partial hepatectomy, we investigated the expression of HGF and TGF-β1 in rats with liver cirrhosis (LC). A rat model of LC was prepared using carbon tetrachloride (CCl4). The expression of HGF mRNA in both the LC and control groups showed a similar time-course with the highest expression seen at 18 h after a 70% hepatectomy. The expression of TGF-β1 mRNA peaked at 18 h after partial hepatectomy in the LC group and at 48 h in the control group. The 5-bromo-2'-deoxyuridine (BrdU) labeling index for the LC group at 24, 48, and 72 h after partial hepatectomy was 9.2%, 5.9%, and 1.8%, while for the control group it was 7.0%, 11.7%, and 6.8%, respectively. The BrdU labeling index in the LC group was thus suppressed earlier than that in the control group. We therefore postulate that regeneration of the remnant liver in the presence of LC accelerates immediately after partial hepatectomy, but the extent of regeneration is insufficient because of an early cessation due to an early expression of TGF-β1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311534
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  • 8
    Electronic Resource
    Electronic Resource
    Treatment for accidental occlusion of the hepatic artery after hepatic resection: Report of two cases (1999)
    Springer
    Surgery today 29 (1999), S. 268-272 
    Details
    ISSN: 1436-2813
    Keywords: hepatic artery occlusion ; hepatic resection ; hepatocyte growth factor ; hepatic vein oxygen saturation ; arterialization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients in whom accidental hepatic artery occlusion (HAO) occurred after hepatic resection (Hx) were reported. A 59-year-old female who underwent Hx for hepatocellular carcinoma with underlying liver cirrhosis developed HAO on postoperative day (POD) 14 and died of hepatic failure on POD 23. The autopsy findings showed multiple necrosis in the remnant liver and an extraluminal hematoma of the hepatic artery, suggesting an injury caused by Pringle's maneuver. The second case was a 53-year-old male who underwent Hx for cholangiocarcinoma without any underlying liver disease. He developed HAO on POD 6, and radiological studies indicated a pseudoaneurysma formation and severe stenosis of the hepatic artery. It was speculated that the cause of the HAO was intraluminal injury of the hepatic artery during an angiographic study conducted prior to Hx. Partial arterialization of the portal vein was performed, following which his liver function test results improved. In both cases, measuring the serum hepatocyte growth factor level and the hepatic vein oxygen saturation proved useful, not only for determining the degree of liver injury, but also for predicting the outcome after treatments for HAO. Furthermore, the partial arterialization of the portal vein for HAO after Hx may rescue the normal remnant liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02483020
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of exogenous prostaglandin E1 in hepatectomized patients (1994)
    Springer
    Journal of hepato-biliary-pancreatic surgery 1 (1994), S. 402-405 
    Details
    ISSN: 1436-0691
    Keywords: prostaglandin E1 ; hepatectomy ; hepatic failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy of prostaglandin E1 (PGE1) in preventing hepatic failure after hepatectomy was investigated prospectively in eight PGE1-treated patients and in seven untreated controls. The patients in the PGE1-treated group received PGE1 (0.03 μg/kg per min) intravenously for 72 h beginning at the initiation of surgery. The cardiac index increased markedly and the systemic vascular resistance decreased markedly during PGE1 treatment, while no significant changes were observed in the control group. The platelet count in the PGE1-treated group decreased slightly, while that in the control group decreased significantly during the first 3 postoperative days. The percent change of alanine aminotranferase in the PGE1-treated group was less than that in the control group. These findings suggest that the administration of exogenous PGE1 following hepatectomy increases hepatic blood flow and suppresses platelet aggregation, and therefore may be cytoprotective to the remnant liver. Thus, PGE1 may be effective in preventing hepatic failure after hepatectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391103
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