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  • 1
    Electronic Resource
    Electronic Resource
    The contribution of mitochondrial calcium ion exchange to relaxation of tension in cardiac muscle (1989)
    Springer
    Molecular and cellular biochemistry 89 (1989), S. 127-133 
    Details
    ISSN: 1573-4919
    Keywords: mitochondria ; sarcoplasmic reticulum ; calcium ; myocytes ; caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The possible contribution of mitochondrial Ca2+ accumulation and release to contractile phenomena has been investigated. Two intracellular fractions of Ca2+ sequestration can be identified in cardiac myocytes, one ascribed to mitochondria. Two modes of Ca2+ transport exist within the mitochondrial fraction, one dependent upon mitochondrial respiration and the other upon extramitochondrial [Na+]. Experiments with trabeculae show that under appropriate conditions, the rate of relaxation and the amount of tension developed is dependent on these two modes of Ca2+ transport. A model is presented quantifying the contribution of the mitochondria to relaxation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220764
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of contractile state on the size of the extracellular space in isolated ventricular myocardium (1979)
    Springer
    Basic research in cardiology 74 (1979), S. 604-610 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Methode beschrieben zur kontinuierlichen Messung des extrazellulären Raumes in isolierter Ventrikelmuskulatur. Die Größe des Extrazellulärraumes variiert mit dem kontraktilen Zustand des Muskels. Eingriffe wie Stillstellung, Mangan und Azidose reduzieren die Kontraktilität und vergrößern den Extrazellulärraum. Barium, Ouabain und Hypoxie verursachen Kontraktur und verkleinern den Extrazellulärraum. Diese Änderungen sollten berücksichtigt werden, wenn intrazelluläre Elektrolyte in isolierten Ventrikelpräparaten bestimmt werden.
    Notes: Summary A method is described with which the extracellular space of isolated ventricular muscle can be measured accurately and continuously in the same muscle. The size of the extracellular space is shown to vary with the contractile state of the myocardium. Interventions such as quiescence, manganese and acidosis reduce myocardial contractility and increase the size of the extracellular space. Barium, ouabain and hypoxia cause contracture and reduce the size of the extracellular space. These changes should be taken into account when measuring intracellular electrolytes in isolated ventricular preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907502
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The isolated perfused rat heart: A model for studying myocardial hypoxia or ischaemia (1984)
    Springer
    Basic research in cardiology 79 (1984), S. 313-321 
    Details
    ISSN: 1435-1803
    Keywords: isolated heart preparation ; hypoxia ; ischaemia ; cardiac metabolism ; cardiac function ; myocardial protection ; bepridil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this paper is to consider the advantages of using isolated heart preparations in studies designed to investigate the effect of hypoxia or ischaemia on myocardial cells. After a brief description of the two most frequently used experimental models of perfused hearts, namely the Langendorff preparation and the working heart preparation, some of the various methods used to induce hypoxia or ischaemia are described, as well as some of the possible techniques allowing to assess metabolic alterations occurring in these pathological situations. After discussing the limitations and advantages specific to the Langendorff and working heart preparations, the suitability of isolated heart models in studies on myocardial protection is then considered. To illustrate this point, the effect of intravenous administration of the slow calcium channel blocker bepridil (5 mg · kg−1) on post-ischaemic recovery of cardiac function and metabolism after global normothermic ischaemia of the isolated heart is reported. It is concluded that isolated heart preparations allow a fine control of experimental conditions with the advantage that functional and metabolic measurements can be easily made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908032
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    Paper (German National Licenses)
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