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  • 1
    Electronic Resource
    Electronic Resource
    Abscesses caused by “dropped” stones after laparoscopic cholecystectomy for cholelithiasis: A Report of three cases (1997)
    Springer
    Surgery today 27 (1997), S. 364-367 
    Details
    ISSN: 1436-2813
    Keywords: laparoscopic cholecystectomy ; dropped stones ; abdominal abscesses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While laparoscopic cholecystectomy is a standard therapeutic option for gallbladder stones, it is associated with a significant risk of injury to the gallbladder wall, which may result in the dispersion of free stones within the peritoneal cavity. However, the incidence and consequences of these dropped stones remains unclear. We report herein the cases of three patients in whom abdominal abscesses developed as a result of dropped stones during this procedure. Of particular interest was the relatively long interval from the procedure to the onset of symptoms and the unusual progression of the inflammation. These case reports strongly reinforce the risk of dropped stones during laparoscopic cholecystectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941815
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The intrapleural administration of recombinant interleukin-2 (rIL-2) to patients with malignant pleural effusion: Clinical trials (1993)
    Springer
    Surgery today 23 (1993), S. 1053-1059 
    Details
    ISSN: 1436-2813
    Keywords: rIL-2 ; malignant pleural effusion ; intrapleural administration ; lymphokine-activated killer activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recombinant IL-2 (rIL-2) was administered intra-pleurally according to an original protocol to 11 patients with malignant pleural effusion, 7 of whom suffered from breast cancer and 4 from esophageal cancer. The pleural effusions either disappeared or decreased roentgenographically, and malignant cells disappeared from all 13 pleural cavities in the 11 patients, confirming the validity of this therapy to be 100%. The mean survival time from the initial administration of rIL-2 was 15.9 months. We ensured that the concentration of IL-2 in the effusion was maintained at a high level for a sufficient period of time, and that the lymphokine-activated killer (LAK) activity of lymphocytes in the effusion was augmented. Fever, eosinophilia, and a transient increase in the pleural effusion were the main side effects, but the symptoms were temporary and not serious. The results of this study therefore suggest the efficacy of intrapleural rIL-2 for patients with malignant pleural effusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309093
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of results of surgery performed over a 20-year period on 500 patients with cancer of the thoracic esophagus (1996)
    Springer
    Surgery today 26 (1996), S. 77-82 
    Details
    ISSN: 1436-2813
    Keywords: thoracic esophageal cancer ; time-lag therapy ; reconstruction via posterior mediastinum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was conducted to examine the long-term outcome of 500 patients who underwent surgery for cancer of the thoracic esophagus during the past 20 years. Favorable results were obtained with postoperative adjuvant radiation and chemotherapy and there were no surgical deaths in the last 5 years. The mortality rate decreased from 17% prior to 1980 to 5% between 1981 and 1993, this being most probably attributable to the decreased incidence of suture leakage. With respect to changes in surgical techniques, during the initial years we performed intrathoracic anastomosis, after which sternal manubrium resection with anterior mediastinal esophagogastrostomy was carried out. Subsequently, we invented a technique for performing esophagogastrostomy via the posterior mediastinum. The posterior mediastinum was selected as the most physiologic route, based on measurement of tissue oxygen tension. Using blood flow determinations obtained by laser-Doppler velocimetry, we concluded that the effectiveness of thicker gastric tubes was superior to that of thin tubes. Esophagogastrostomy was performed in a shallow field in the cervical region, with the anastomosis ultimately positioned in the superior mediastinum and covered with mediastinal pleura.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311768
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Abdominal tuberculoma mimicking a pancreatic neoplasm: Report of a case (1995)
    Springer
    Surgery today 25 (1995), S. 365-368 
    Details
    ISSN: 1436-2813
    Keywords: tuberculoma ; abdominal tumor ; pancreatic neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein a case of clinically solitary abdominal tuberculoma. A 28-year-old woman was admitted to hospital for treatment of an abdominal tumor shown to be located in the head of the pancreas and compressing the superior mesenteric vein by echosonography and computed tomography (CT). There were no clinical signs or symptoms of tuberculosis in the lungs or abdomen. Thus, under the diagnosis of a neoplasm of the pancreas, an exploratory laparotomy was performed which revealed tuberculosis. The patient made an excellent recovery on anti-tuberculous treatment, and no evidence of a tumor was seen on a CT scan performed 6 months after the initiation of treatment. Abdominal tuberculoma is often mistaken for a malignant neoplasm and the nonsurgical diagnosis of this entity continues to be a challange.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311262
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A novel point mutation in an acceptor splice site of intron 32 (IVS32 A–12→G) but no exon 3 mutations in the glycogen debranching enzyme gene in a homozygous patient with glycogen storage disease type IIIb (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 1-5 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Genetic deficiency of the glycogen-debranching enzyme (debrancher) causes glycogen storage disease type III (GSD III), which is divided into two subtypes: IIIa and IIIb. In GSD IIIb, glycogen accumulates only in the liver, whereas both liver and muscles are involved in GSD IIIa. The molecular basis for the differences between the two subtypes has not been fully elucidated. Recently, mutations in exon 3 of the debrancher gene were reported to be specifically associated with GSD IIIb. However, we describe a homozygous GSD IIIb patient without mutations in exon 3. Analysis of the patient’s debrancher cDNA revealed an 11-bp insertion in the normal sequence. An A to G transition at position –12 upstream of the 3′ splice site of intron 32 (IVS 32 A–12→G) was identified in the patient’s debrancher gene. No mutations were found in exon 3. Mutational analysis of the family showed the patient to be homozygous for this novel mutation as well as three polymorphic markers. Furthermore, the mother was heterozygous and the parents were first cousins. The acceptor splice site mutation created a new 3′ splice site and resulted in insertion of an 11-bp intron sequence between exon 32 and exon 33 in the patient’s debrancher mRNA. The predicted mutant enzyme was truncated by 112 amino acids as a result of premature termination. These findings suggested that a novel IVS 32 A–12→G mutation caused GSD IIIb in this patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050646
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    Paper (German National Licenses)
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