Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Radiation therapy in patients with unresectable hepatocellular carcinoma (1992)
    Springer
    Cancer chemotherapy and pharmacology 31 (1992), S. S106 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From April 1978 through December 1989, a total of 17 patients with unresectable hepatocellular carcinoma (HCC) were treated with radiation therapy alone or radiation therapy in conjunction with percutaneous ethanol injection (PEI), transarterial infusion chemotherapy (TAI), or transarterial embolization (TAE) at the National Medical Center Hospital. The median survival of all patients was 13.8 months. The survival values determined at 1, 2, and 3 years were 58.8%, 26.1%, and 9.8%, respectively. Only the pretreatment liver function affected the survival value. Between patients who did not have liver cirrhosis (LC) as well as those who had LC of Child's class A and patients who had LC of Child's class B or C, the differences observed in the 1-year survival value and the median duration of survival were statistically significant (P〈0.05). The serum cholinesterase (ChE) level seemed to be a good indicator of liver function during the radiation therapy. A field size of 150 cm2 and a total dose of 5000 cGy (TDF 82) seemed to be well tolerated by patients who did not have LC and those who had LC of Child's class A. The field size determined whether patients with poor liver function such as LC of Child's class B or C would develop severe hepatic deterioration after undergoing radiation therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687118
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hepatic irradiation in primary and metastatic liver cancer (1989)
    Springer
    Cancer chemotherapy and pharmacology 23 (1989), S. S49 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between December 1973 and September 1987, 21 patients with primary liver cancer and 41 patients with metastatic liver cancer were treated with external irradiation, intra-arterial infusion chemotherapy and/or transarterial embolization (TAE) at the National Medical Center Hospital, the National South Kyushu Central Hospital and the National Kure Hospital. Of the patients with primary liver cancer, 13 cases were treated with intra-arterial infusion chemotherapy (30–40 mg adriamycin or 10 mg mitomycin C) and hepatic irradiation. Eight cases were treated by TAE and hepatic irradiation. In the Child A group, the survival period of the chemotherapy + hepatic irradiation cases (mean: 608 days) was longer than that of the TAE + hepatic irradiation cases (mean: 216 days). The median survival period of all the cases was 7.0 months (mean: 10.9 months). For 16 of the 21 patients (who had absorbed over 40 Gy), the median survival period was 11.9 months (mean: 11.7 months). For 5 of the 21 patients (who had absorbed below 40 Gy), the median survival period was 4.3 months (mean: 7.9 months). Of the patients with metastatic liver cancer, the median survival period was 7.2 months (mean: 8.0 months). For 22 of the 41 patients (who had absorbed over 40 Gy), the median survival was 7.9 months (mean: 12.6 months). For 19 of the 41 patients (who had absorbed below 40 Gy), the median survival period was 1.7 months (mean: 2.6 months). The pretreatment serum GOT (glutamate oxaloacetate transaminase) levels and the pretreatment Karnofsky performance status index were the factors governing the prognosis of the cases with metastatic liver cancer, while toxicity was generally mild.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647240
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Thallium-201 single-photon emission tomography in the treatment follow-up of nasopharyngeal carcinoma (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 305-311 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Thallium-201 ; Single-photon emission tomography ; Nasopharyngeal carcinoma ; Treatment response ; Therapeutic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In order to assess the usefulness of thallium-201 single-photon emission tomography (SPET) in the treatment follow-up of nasopharyngeal carcinoma (NPC), a total of 75 201Tl SPET studies were performed in 18 patients with histologically proven NPC. The findings were compared with those of magnetic resonance imaging (MRI) before and after therapy. Four patients received radiotherapy alone while the other 14 received concurrent chemo-radiotherapy. Treatment response was classified as complete (CR) or partial (PR) based on the findings of MRI and 201Tl SPET. Intense 201Tl uptake by the tumour was seen in all 18 patients before treatment. After treatment, MRI showed seven CRs and 11 PRs, whereas 201Tl SPET showed 13 CRs and five PRs. In 12 patients, the results of 201Tl SPET were in agreement with those of MRI. In six patients MRI showed PR but 201Tl showed CR. Follow-up (mean 10.6 months) MRI and 201Tl SPET studies of these six patients revealed that tumour gradually decreased and finally vanished in three patients. This preliminary study indicates that 201Tl SPET has potential in the assessment of early response to treatment of patients with NPC when compared with MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728768
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Thallium-201 single-photon emission tomography in the treatment follow-up of nasopharyngeal carcinoma (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 305-311 
    Details
    ISSN: 1619-7089
    Keywords: Thallium-201 ; Single-photon emission tomography ; Nasopharyngeal carcinoma ; Treatment response ; Therapeutic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to assess the usefulness of thallium-201 single-photon emission tomography (SPET) in the treatment follow-up of nasopharyngeal carcinoma (NPC), a total of 75201Tl SPET studies were performed in 18 patients with histologically proven NPC. The findings were compared with those of magnetic resonance imaging (MRI) before and after therapy. Four patients received radiotherapy alone while the other 14 received concurrent chemo-radiotherapy. Treatment response was classified as complete (CR) or partial (PR) based on the findings of MRI and201Tl SPET. Intense201Tl uptake by the tumour was seen in all 18 patients before treatment. After treatment, MRI showed seven CRs and 11 PRs, whereas201Tl SPET showed 13 CRs and five PRs. In 12 patients, the results of201Tl SPET were in agreement with those of MRI. In six patients MRI showed PR but201Tl showed CR. Follow-up (mean 10.6 months) MRI and201Tl SPET studies of these six patients revealed that tumour gradually decreased and finally vanished in three patients. This preliminary study indicates that201Tl SPET has potential in the assessment of early response to treatment of patients with NPC when compared with MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728768
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Bacterial translocation of intestinalPseudomonas aeruginosa in post-burn infection of mice (1996)
    Springer
    Journal of infection and chemotherapy 1 (1996), S. 193-196 
    Details
    ISSN: 1437-7780
    Keywords: endogenous infection ; burn ; bacterial translocation ; Pseudomonas aeruginosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The significance of intestinalPseudomonas aeruginosa as a pathogen of post-burn infection in mice was established. Mice with and withoutP. aeruginosa intestinal colonization were scorched with a deep dermal burn by ethanol flame on the shaven back, involving approximately 25% of the total body surface area. Eight hours later,P. aeruginosa of a serotype similar to that previously administered (per os) was detected in the burn site, liver, and spleen ofP. aeruginosa-treated, but not the control, animals. Within three post-burn days, 33.3% of theP. aeruginosa-treated, burned mice died of infection-derived sepsis, whereas none of the control mice died. In addition, when the orally nonabsorbable antibiotics, polymyxin B (12 mg/kg) and vancomycin (30 mg/kg), were administered by intragastric injection toP. aeruginosa-treated mice immediately after burn exposure, the mortality rate significantly decreased to 16.1±6.1% compared with 35.0±5.0% in similarly colonized, burned mice not given these oral antibiotics (P〈0.05). These findings suggest thatP. aeruginosa colonized in the intestinal tract is noxious and can be fatal as a pathogen of post-burn infection. Furthermore, our report suggests that selective digestive decontamination (decontamination of endogenous pathogens in the intestinal tract) is essential in preventing post-burn infection associated with bacterial translocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02350648
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Role of motility in the endogenousPseudomonas aeruginosa sepsis after burn (1996)
    Springer
    Journal of infection and chemotherapy 2 (1996), S. 240-246 
    Details
    ISSN: 1437-7780
    Keywords: burn ; sepsis ; motility ; Pseudomonas aeruginosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the relationship between bacterial motility and the lethal endogenous sepsis after burn in mice orally challenged withPseudomonas aeruginosa, by using motility mutants. The mortality rates of postburn endogenous sepsis in mice orally challenged with low-motility mutants (strains B16–40 and B16–46) were 12% and 7.7%, respectively. By contrast, the mortality rates in mice who had been fed a high-motility mutant (B16–52) or the parentalP. aeruginosa B16 (a high-motility strain) were 36% and 33%, respectively. Significant differences were found for mortality rates in groups fed the high-motility or lowmotility strains. A multiple regression analysis examining the effect of motility, number of cecalP. aeruginosa cells, and production of exotoxin A and total protease on the murine mortality rates associated with the 3 motility mutants and the parental strain showed a linear relationship between murine mortality and bacterial motility. In addition, when human monoclonal antibody specific for type-b flagella proteins ofP. aeruginosa was intravenously administrated to mice orally challenged withP. aeruginosa B16, the mortality rate significantly decreased to 5.6%, compared with 33% in similar mice given intravenous saline. These results suggest that the occurrence of the lethal endogenous sepsis after burn in mice was closely related to the motility of theP. aeruginosa colonized in their intestinal tract, and that motility is an important virulence factor in endogenousP. aeruginosa sepsis after burn injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02355121
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...